Table 12 Histopathological findings: summary of neoplastic (benign) or neoplastic (malignant) in female
Test article | Nontreatment | Control | MWNT-7 | VGCF™-H | ||||
|---|---|---|---|---|---|---|---|---|
Total dose (mg/kg) | 0.13 | 0.64 | 3.2 | 0.13 | 0.64 | 3.2 | ||
Number of animals | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 |
Heart | ||||||||
Schwannoma, intramural | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 |
Pituitary | [17]b | [21]b | [19]b | [16]b | [13]b | [21]b | [25]b | [21]b |
Adenoma, pars distalis | 8 | 12 | 15 | 10 | 7 | 13 | 16 | 10 |
Adenoma, pars intermedia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Carcinoma, pars distalis | 2 | 0 | 1 | 1 | 2 | 1 | 4 | 2 |
Thyroid | [6]b | [3]b | [3]b | [2]b | [3]b | [5]b | [7]b | [5]b |
Adenoma, C-cell | 4 | 2 | 1 | 2 | 3 | 4 | 5 | 3 |
Carcinoma, C-cell | 2 | 1 | 1 | 0 | 0 | 1 | 3 | 1 |
Adrenal | [3]b | [2]b | [1]b | [3]b | [1]b | |||
Adenoma, cortical | 0 | 0 | 0 | 0 | 1 | |||
Ganglioneuroma, benign | 0 | 1 | 0 | 0 | 0 | |||
Pheochromocytoma, complex, malignant | 0 | 0 | 1 | 0 | 0 | |||
Pheochromocytoma, malignant | 1 | 0 | 0 | 0 | 0 | |||
Lung/bronchial | ||||||||
Epithelioma, non-keratinizing | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Stomach | [1]b | [1]b | [4]b | [2]b | [3]b | [2]b | ||
Papilloma, squamous cell | 0 | 0 | 0 | 0 | 1 | 0 | ||
Jejunum | [1]b | [1]b | [1]b | [1]b | ||||
Leiomyosarcoma | 0 | 0 | 1 | 0 | ||||
Cecum | [1]b | [2]b | [1]b | |||||
Leiomyoma | 1 | 0 | 0 | |||||
Lipoma | 0 | 1 | 0 | |||||
Colon | [1]b | [1]b | ||||||
Leiomyosarcoma | 0 | 1 | ||||||
Liver | ||||||||
Adenoma, hepatocellular | 0 | 1 | 0 | 2 | 2 | 0 | 0 | 3 |
Carcinoma, hepatocellular | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cholangiocarcinoma | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Kidney | ||||||||
Hemangioma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Carcinoma | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Urinary bladder | [1]b | [2]b | [2]b | |||||
Carcinoma, transitional cell | 0 | 0 | 0 | |||||
Prep./ Clit. gland | [4]b | [2]b | [5]b | [1]b | [3]b | |||
Adenoma | 2 | 0 | 0 | 0 | 2 | |||
Adenocarcinoma | 1 | 2 | 5 | 1 | 1 | |||
Mammary gland | [9]b | [10]b | [11]b | [8]b | [6]b | [14]b | [11]b | [8]b |
Adenoma | 0 | 0 | 1 | 1 | 0 | 1 | 2 | 2 |
Fibroadenoma | 4 | 8 | 7 | 7 | 6 | 11 | 9 | 6 |
Fibroma | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Adenocarcinoma | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 2 |
Ovary | [3]b | [1]b | [6]b | [2]b | [1]b | [5]b | [4]b | |
Cystadenoma | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |
Luteoma | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
Tumor, granulosa cell, benign | 0 | 0 | 0 | 0 | 0 | 0 | 3 | |
Uterus | [8]b | [11]b | [9]b | [6]b | [3]b | [5]b | [8]b | [9]b |
Leiomyoma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Polyp, endometrial stromal | 3 | 5 | 3 | 1 | 1 | 4 | 3 | 6 |
Polyp, glandular | 0 | 0 | 2 | 0 | 1 | 0 | 3 | 0 |
Adenocarcinoma | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Leiomyosarcoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Malignant schwannoma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Sarcoma, endometrial stromal | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Skin/subcutis | [3]b | [1]b | [3]b | [1]b | [1]b | [3]b | [2]b | [3]b |
Adenoma, sebaceous cell | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Fibroma | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Keratoacanthoma | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Malignant fibrous histiocytoma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Malignant schwannoma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Osteosarcoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Brain | [5]b | [2]b | [6]b | [2]b | [4]b | [10]b | [10]b | [8]b |
Invasion (pituitary: carcinoma pars distalis) | 2 | 0 | 0 | 0 | 2 | 1 | 1 | 2 |
Spinal cord | [1]b | [2]b | [1]b | |||||
Astrocytoma, malignant, high grade | 0 | 0 | 1 | |||||
Astrocytoma, malignant, low grade | 0 | 1 | 0 | |||||
Abdominal cavity | [1]b | [1]b | ||||||
Mesothelioma, malignant | 0 | 1 | ||||||
Sarcoma, NOS | 1 | 0 | ||||||
Oral cavity | [1]b | |||||||
Carcinoma, squamous cell | 1 | |||||||
Trigeminal nerve | [1]b | |||||||
Neurofibrosarcoma | 1 | |||||||
All sites | [6]b | [4]b | [6]b | [8]b | [1]b | [7]b | [6]b | [5]b |
Histiocytic sarcoma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Large granular lymphocyte leukemia | 4 | 3 | 5 | 4 | 1 | 5 | 4 | 5 |
Lymphocytic lymphoma | 2 | 1 | 0 | 4 | 0 | 2 | 2 | 0 |
Site unknown | [1]b | |||||||
Endocrine tumor | 1 | |||||||