Table 2 Cellular components in the PLF at week 13 of the experimental period
Test article | Total dose (mg/kg) | Female | ||||||
|---|---|---|---|---|---|---|---|---|
WBC (× 102/µL) | Leukocytes, differential | |||||||
Lymphocytes | Neutrophils | Eosinophils | Basophils | Monocytes | ||||
(× 102/µL) | (× 102/µL) | (× 102/µL) | (× 102/µL) | (× 102/µL) | ||||
Nontreatment | – | (5) | 20.2 ± 5.6 | 1.4 ± 0.3 | 3.1 ± 1.0 | 1.3 ± 0.4 | 0.0 ± 0.0 | 14.4 ± 4.0 |
Control | 0 | (5) | 20.3 ± 6.4 | 1.5 ± 0.4 | 3.2 ± 1.0 | 1.2 ± 0.4 | 0.0 ± 0.0 | 14.4 ± 4.9 |
MWNT-7 | 0.128 | (5) | 30.2 ± 3.3 | 2.3 ± 0.4# | 2.4 ± 0.5 | 2.1 ± 0.4# | 0.0 ± 0.0 | 23.4 ± 2.2# |
MWNT-7 | 0.64 | (5) | 39.3 ± 9.9# | 2.1 ± 0.5 | 2.8 ± 1.1 | 4.2 ± 1.5# | 0.0 ± 0.0 | 30.2 ± 7.1# |
MWNT-7 | 3.2 | (5) | 41.8 ± 14.8## | 1.5 ± 0.4 | 3.4 ± 0.7 | 6.5 ± 2.5# | 0.0 ± 0.0 | 30.4 ± 12.3 |
VGCF™-H | 0.128 | (5) | 22.1 ± 4.7 | 1.9 ± 0.6 | 3.1 ± 0.6 | 1.3 ± 0.4 | 0.0 ± 0.0 | 15.9 ± 3.9 |
VGCF™-H | 0.64 | (5) | 20.6 ± 5.4 | 1.7 ± 0.7 | 2.7 ± 1.3 | 1.3 ± 0.3 | 0.0 ± 0.0 | 14.9 ± 3.6 |
VGCF™-H | 3.2 | (5) | 23.9 ± 6.7 | 1.9 ± 0.6 | 1.8 ± 0.6 | 1.4 ± 0.4 | 0.0 ± 0.0 | 18.7 ± 5.5 |
Test article | Total dose (mg/kg) | Male | ||||||
|---|---|---|---|---|---|---|---|---|
WBC (× 102/µL) | Leukocytes, differential | |||||||
Lymphocytes | Neutrophils | Eosinophils | Basophils | Monocytes | ||||
(× 102/µL) | (× 102/µL) | (× 102/µL) | (× 102/µL) | (× 102/µL) | ||||
Nontreatment | – | (5) | 35.6 ± 7.7 | 2.2 ± 0.9 | 3.4 ± 1.5 | 1.6 ± 0.2 | 0.0 ± 0.0 | 28.4 ± 5.7 |
Control | 0 | (5) | 28.5 ± 10.5 | 1.7 ± 0.5 | 3.0 ± 0.9 | 1.3 ± 0.3 | 0.0 ± 0.0 | 22.6 ± 9.3 |
MWNT-7 | 0.128 | (5) | 37.6 ± 10.6 | 2.5 ± 0.6# | 3.1 ± 0.7 | 2.6 ± 0.6# | 0.0 ± 0.0 | 29.4 ± 9.2 |
MWNT-7 | 0.64 | (5) | 69.7 ± 10.2## | 3.1 ± 0.6## | 6.2 ± 1.8## | 7.7 ± 1.7# | 0.0 ± 0.0 | 52.8 ± 6.5## |
MWNT-7 | 3.2 | (5) | 93.0 ± 12.1## | 1.6 ± 0.2 | 6.3 ± 1.9## | 14.9 ± 3.0# | 0.0 ± 0.0 | 70.3 ± 9.0## |
VGCF™-H | 0.128 | (5) | 30.9 ± 3.0 | 1.9 ± 0.3 | 3.1 ± 0.7 | 1.3 ± 0.3 | 0.0 ± 0.0 | 24.6 ± 2.9 |
VGCF™-H | 0.64 | (5) | 34.9 ± 8.0 | 2.4 ± 0.6 | 3.3 ± 1.2 | 1.4 ± 0.2 | 0.0 ± 0.0 | 27.7 ± 6.4 |
VGCF™-H | 3.2 | (5) | 40.1 ± 7.8 | 2.6 ± 0.7# | 3.1 ± 0.8 | 1.9 ± 0.4# | 0.0 ± 0.0 | 32.5 ± 6.2 |