Table 3 The differential metabolites between the control and MPDA groups
From: The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles
Ionization mode | Identification | Â | Formula | RT (min) | Measured Mass (m/z) | MPDA | Control | Pathway |
|---|---|---|---|---|---|---|---|---|
ESI- | N-Acetylneuraminic acid |  | C11 H19 N O9 | 0.792 | 308.0987 | ↓** | ↑** | Arginine biosynthesis |
|  | Inosine |  | C10 H12 N4 O5 | 1.468 | 267.0734 |  | ↑* | Purine metabolism |
|  | adrenosterone |  | C19 H24 O3 | 7.314 | 299.1653 | ↓** | ↑** | Steroid hormone biosynthesis |
|  | Arachidonic acid |  | C20 H32 O2 | 12.716 | 303.2328 | ↑** | ↓** | Biosynthesis of unsaturated fatty acids |
|  | Eicosapentaenoic acid |  | C20 H30 O2 | 12.12 | 301.2171 | ↑** | ↓** | Biosynthesis of unsaturated fatty acids |
|  | Estriol |  | C18 H24 O3 | 6.948 | 333.1709 | ↓* | ↑** | Steroid hormone biosynthesis |
|  | Uridine |  | C9 H12 N2 O6 | 1.223 | 243.0621 | ↓** | ↑** | Pyrimidine metabolism |
|  | alpha-Linolenic acid |  | C18 H30 O2 | 12.218 | 277.2171 | ↑** | ↓** | alpha-Linolenic acid metabolism, Biosynthesis of unsaturated fatty acids |
|  | Cholic acid |  | C24 H40 O5 | 7.043 | 407.2799 | ↓** | ↑** | Primary bile acid biosynthesis |
|  | Guanosine monophosphate |  | C10 H14 N5 O8 P | 1.438 | 362.0494 | ↑** | ↓** | Purine metabolism |
|  | 4-Pyridoxic acid |  | C8 H9 N O4 | 1.65 | 182.0451 | ↓** | ↑** | Vitamin B6 metabolism |
|  | N-Acetylglutamic acid |  | C7 H11 N O5 | 1.256 | 188.0557 | ↓** | ↑** | Arginine and proline metabolism |
|  | Uric acid |  | C5 H4 N4 O3 | 0.838 | 167.0201 | ↑** | ↓** | Purine metabolism |
|  | 2-Oxoglutaric acid |  | C5 H6 O5 | 0.841 | 145.0132 | ↓** | ↑** | Arginine biosynthesis, TCA cycle, Alanine, aspartate, and glutamate metabolism, Butanoate metabolism, D-Glutamine, and D-glutamate metabolism |
|  | L-Methionine |  | C5 H11 N O2 S | 1.222 | 148.0427 | ↓** | ↑** | Cysteine and methionine metabolism, Aminoacyl-tRNA biosynthesis |
|  | 2-Oxo-4-methylthiobutanoic acid |  | C5 H8 O3 S | 2.403 | 147.011 | ↓** | ↑** | Cysteine and methionine metabolism |
|  | 4-Oxoproline |  | C5 H7 N O3 | 0.835 | 128.0341 | ↓** | ↑** | Glutathione metabolism |
|  | Hypoxanthine |  | C5 H4 N4 O | 1.22 | 135.0301 | ↓* | ↑** | Purine metabolism |
|  | Glyceric acid |  | C3 H6 O4 | 0.836 | 105.018 | ↓** | ↑** | Glycine, serine and threonine metabolism, Glycerolipid metabolism, Glyoxylate and dicarboxylate metabolism, and Pentose phosphate pathway |
|  | 2-Hydroxybutyric acid |  | C4 H8 O3 | 1.277 | 103.0388 |  | ↑** | Propanoate metabolism |
|  | 2-Oxobutyrate |  | C4 H6 O3 | 0.827 | 101.0231 | ↓* | ↑** | Cysteine and methionine metabolism, Valine, leucine, and isoleucine biosynthesis, Propanoate metabolism, Glycine, serine and threonine metabolism |
|  | L-Lactic acid |  | C3 H6 O3 | 0.898 | 89.02303 | ↑* | ↓** | Glycolysis / Gluconeogenesis, Pyruvate metabolism |
ESI+ | Thymine |  | C5 H6 N2 O2 | 1.819 | 127.0502 |  | ↑** | Pyrimidine metabolism |
|  | L-Pyroglutamic acid |  | C5 H7 N O3 | 1.25 | 130.0499 | ↑** | ↑** | Glutathione metabolism |
|  | Nicotinic acid |  | C6 H5 N O2 | 1.232 | 124.0394 | ↓* | ↑** | Nicotinate and nicotinamide metabolism |
|  | Hypoxanthine |  | C5 H4 N4 O | 0.851 | 137.0457 | ↓* | ↑** | Purine metabolism |
|  | Nicotinamide |  | C6 H6 N2 O | 5.757 | 123.0554 | ↑** | ↓** | Nicotinate and nicotinamide metabolism |
|  | L-Methionine |  | C5 H11 N O2 S | 0.87 | 150.0582 | ↓** | ↑** | Cysteine and methionine metabolism, Aminoacyl-tRNA biosynthesis |
|  | Adenosine |  | C10 H13 N5 O4 | 1.454 | 268.1035 | ↓** | ↑** | Purine metabolism |
|  | Inosine |  | C10 H12 N4 O5 | 1.473 | 269.0877 |  | ↑* | Purine metabolism |
|  | β-Estradiol |  | C18 H24 O2 | 7.067 | 273.1844 | ↓** | ↑** | Steroid hormone biosynthesis |
|  | D-Proline |  | C5 H9 N O2 | 1.241 | 116.0709 | ↑** | ↑** | Arginine and proline metabolism |
|  | Dehydroepiandrosterone |  | C19 H28 O2 | 7.433 | 289.2156 | ↓** | ↑** | Steroid hormone biosynthesis |
|  | Uracil |  | C4 H4 N2 O2 | 1.24 | 113.0348 | ↓** | ↑** | Pyrimidine metabolism, beta-Alanine metabolism, Pantothenate and CoA biosynthesis |
|  | Arachidonic acid |  | C20 H32 O2 | 12.715 | 305.2467 | ↑** | ↑** | Biosynthesis of unsaturated fatty acids, Arachidonic acid metabolism |
|  | Phytosphingosine |  | C18 H39 N O3 | 7.678 | 318.2992 | ↓** | ↓** | Sphingolipid metabolism |
|  | 3-HYDROXYPROPIONIC ACID |  | C3 H6 O3 | 0.807 | 91.03943 | ↑** | ↓** | beta-Alanine metabolism, Propanoate metabolism |