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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Maternal exposure to nano-titanium dioxide impedes fetal development via endothelial-to-mesenchymal transition in the placental labyrinth in mice

Fig. 5

TiO2 NPs activated EndMT in the placental labyrinth. a, b TiO2 NPs exposure induced vimentin (Vim) expression and suppressed CD31 expression in the labyrinth in a dose-dependent manner. c The qPCR results revealed that TiO2 NPs activated the TGF-β-SNAIL pathway (Tgfb, Twist, Snail, and Slug), enhanced mesenchymal marker genes (Vim and Cdh2), and suppressed endothelial marker genes (Kdr and Cd31). Data are presented as mean ± SEM. n = 3 placentas from 3 mice for Immunofluorescence staining; n = 7 placentas from 7 mice for qPCR. *p < 0.05 and **p < 0.01 as compared with the normal control (NC)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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