Fig. 5

The lobe specific airway surface area-normalized deposition fraction of a regular and b mentholated little cigar smoke in male and female rat’s lungs. Bars represent mean ± standard error for each lobe (n = 5). Bars with the different letters indicate significant difference (P < 0.05) between lobes within the same sex of rats according to one-way ANOVA with the Tukey’s HSD test. Statistical analyses on male and female rats’ data were conducted separately and thus the annotated letters should be interpreted separately. There were no statistical differences in the normalized deposition fraction across the lobes for male and female rats exposed to regular little cigars. As a result, panel a does not contain any letter annotations