Table 1 Summary of multi-path particle dosimetry model input parameters
Input parameter | Male | Female |
|---|---|---|
Species | Rat | Rat |
Model | Asymmetric Sprague-Dawley | Asymmetric Sprague-Dawley |
Body weight (gram) | 332 | 221 |
FRC volume (mL) | 3.69 | 3.02 |
URT volume | 0.44 | 0.34 |
Particle density (g/cm3) | 1.180 | 1.180 |
Aspect ratio | 1 | 1 |
Diameter (CMD) (nm) | 359 | 359 |
Geometric SD | 1.79 | 1.79 |
Concentration (mg/m3) | 84 | 84 |
Breathing frequency (/minute) | 113 | 125 |
Tidal volume (mL) | 2.32 | 1.62 |
Inspiratory fraction | 0.5 | 0.5 |
Pause fraction | 0 | 0 |
Breathing scenario | Whole body exposure | Whole body exposure |
Dose metric | Deposition only | Deposition only |