Fig. 6

Protective effects of melatonin on PS-NP-induced mitochondrial dysfunction and excessive mitophagy in differentiated SH-SY5Y cells. Differentiated SH-SY5Y cells were exposed to 500 μg/mL PS-NPs with or without Mel (16 μM) for 48 h. A Cell viability and B ATP levels. The quantification of protein expression levels of C PINK1, D Parkin, E LC3-II/LC3-I, F p62, G pAMPK/AMPK, and H pULK1/ULK1. Results are presented as mean ± SD (n = 3). * P < 0.05, ** P < 0.01, *** P < 0.001, compared to the 0 μg/mL group or indicative group. Note: Mel, melatonin