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Table 3 Epithelial markers of phase 1 and 2 xenobiotic metabolism

From: Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response

 

Air

Diesel

p-value

Epi. CYP1A1 (%)

0.31 (0.13–0.55)

0.36 (0.19–1.2)

0.028

Epi. CYP1B1 (%)

0.38 (0.08–0.63)

0.34 (0.17–0.90)

NS

Epi. NQO1 (%)

6.55 (3.96–8.83)

3.42 (2.04–7.08)

0.02

Epi. AKR1A1 (%)

0.59 (0.27–0.87)

0.75 (0.46–0.96)

NS

Epi. AKR1C1 (%)

0.31 (0.10–0.86)

0.61 (0.16–0.98)

NS

Epi. AKR1C3 (%)

1.27 (0.56–2.12)

1.08 (0.45–2.33)

NS

Epi. Epoxide hydrolase (%)

0.020 (0.010–0.036)

0.020 (0.011–0.040)

NS

  1. Definition of abbreviations: Epi. = epithelium. Data are presented as median and (interquartile ranges). Stained epithelial area expressed as % of the selected epithelial area. Comparisons between post air and DE performed using the Wilcoxon-signed-rang-test (n = 16)
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Particle and Fibre Toxicology

ISSN: 1743-8977

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