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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism

Fig. 5

The liver metabolomics analysis in mice. A and B: PCA score plots of ESI +  and ESI −  modes of UPLC-Q-TOF, respectively (In the figure, C represents control group, M represents model group, P represents 5-ASA positive control group, and H represents NPs-H high dose group). C: The ChemRICH enrichment plots illustrated the markedly affected metabolites clusters in this study (p < 0.05). The plot y-axis represented the remarkably changed clusters. The total number of metabolites was represented by the sizes of the node. The colors of the cluster indicated the trend of increased or decreased metabolites (red = totally increased, blue = totally reduced, fuchsia = both but major increased, dark orchid = both but major decreased). D: Pathway analysis of 64 differential metabolites in the liver. E: Heat map of 36 differential metabolites between model and NPs-H groups

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Particle and Fibre Toxicology

ISSN: 1743-8977

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