Fig. 6

The liver lipidomic analysis in mice. A and B: PLS-DA score plots between the model group and the NPs-H group in the positive (a, R²=0.99449, Q²=0.67579) and negative (b, R²=0.99944, Q²=0.53059) modes, respectively. C: The ChemRICH enrichment plots illustrated the markedly affected lipids metabolites clusters in this study (p < 0.05). The plot y-axis represented the remarkably changed clusters. The total number of metabolites was represented by the sizes of node. The colors of the cluster indicated the trend of increased or decreased metabolites (red = totally increased, blue = totally reduced, fuchsia = both but major increased, dark orchid = both but major decreased). D: Pathway analysis of 88 differential lipids in the liver. E: Heat map of 57 differential lipids between the model group and the NPs-H group. F: Pearson correlation analysis between oxidative stress index and 38 differential lipids of the liver. Red = positively relevant, blue = negatively relevant. (*p < 0.05, **p < 0.01, ***p < 0.001)