Fig. 4
Bio-distribution data of the intra-tracheally instilled 64Cu-DOTA-mPS (n = 5), 64Cu-DOTA-nPS (n = 5) and 64Cu (n = 3) groups for all organ systems. The instilled radioactivity can be seen distributed to various organs especially stomach, small intestine, large intestine, liver, spleen, kidneys, and thymus. The data suggests that 64Cu subsequently crossed the ABB in the lungs and got accumulated in the liver by 12 h and also in other organs in small amounts. However, mPS and nPS retained in the lungs and cleared slowly as compared to 64Cu. Faster clearance from the lungs to other organs like liver can be noted in nPS data as compared to the mPS bio-distribution results. The %ID/g in the lung for mPS was significantly different than that of 64Cu and nPS at all time points. mPS = micro-polystyrene; nPS = nano-polystyrene. (*P < 0.05, **P < 0.005, ***P < 0.0005 Student t test)