Fig. 6

Similarity between the protein coronas identified on MNPs. A Heatmap indicating the Pearson correlation coefficient between the median amount of all identified proteins identified on each PS MNP type. The dendrogram shown to the left of the heatmap indicates hierarchical clustering of the different MNPs, and the X- and Y-axes indicate the treatment-particle combination. The bar to the right of the heatmap indicates the Pearson correlation coefficient corresponding to each color. In the legend on the X- and Y-axes, Ser refers to serum-coated particles, while DIG+Ser refers to digested+serum-coated particles. B Principal component analysis of proteomics samples. Filled squares represent serum-coated MNPs, and filled circles represent digested+serum-coated MNPs. Each symbol represents an LC‒MS–MS sample. The color of each symbol indicates the MNP type, with black corresponding to PS100, red corresponding to PS100 (+), green corresponding to PS100 (−) and blue corresponding to PS1000 MNPs. (n = 3)