Fig. 9

Overview of proteins present in a PS MNP corona that correlated with particle uptake. Pearson correlation coefficient of the protein abundance with MNP uptake of the 40 most correlated proteins. Correlated proteins were defined as having an absolute correlation if the coefficient > 0.5. MNP uptake was determined using flow cytometry and was defined as the average relative light unit per treatment condition. Protein abundance in the MNP corona was obtained using LC‒MS–MS and was defined as the average LFQ of the triplicate samples. The numbers shown on the x-axis refer to the proteins listed in Table 7. The y-axis shows the Pearson correlation coefficient. A positive coefficient indicates that the protein is correlated with uptake, while a negative correlation coefficient indicates that the protein is inversely correlated with uptake. The color (black or white) indicates whether the protein is correlated or inversely correlated (p < 0.05, see Table 7)