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Table 6 Proteins uniquely differentially present in a specific PS MNP corona

From: The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages

Condition

Unique differentially abundant proteins

Serum-coated PS 100

F1N045 (Complement C7)

Q3MHL4 (Adenosylhomocysteinase)

F1MB08 (phosphopyruvate hydratase)

F1MW44(coagulation factor 13 chain)

Q2HJ57 (Coactosin like protein)

Q27967 (Secreted phosphoprotein 24)

Q2KJ83 (carboxypeptidase N-catalytic chain)

G3MZI7 (Collagen type V alpha chain)

P80012 (von willebrand factor)

Q28085 (complement factor H)

P17697 (Clusterin)

Q0VCM5 (ITIH 1)

P00735 (Prothrombin)

A5D7R6 (ITIH-2)

A0A3Q1NJR8 (Antithrombin-3)

Serum-coated PS100 (+)

A0A0A0MP92 (Endopin 2)

E1BF81 (Corticosteroid binding globulin)

A0A0A0MPA0 (Serpin domain containing protein)

P13605 (Fibromodulin)

F6RMV5 (Leucine rich alpha-2-glycoprotein 1)

Q9TT36 (Thyoxine-binding globulin)

P01267 (Thyroglobulin)

F1MPD1 (Mannose receptor C type 2)

A6QPQ2 (Serpin A3)

P01017 (Angiotensinogen)

O77742 (Osteomodulin)

I2E4T6 (MBL assosciated serine protease 2)

Q09TE3 (ILGF-binding protein labile subunit)

Q95M17 (Acidic mamalian chitinase)

A0A287BDF8 (Inositol-3-phosphate synthase 1)

F1MPE1 (CD109)

F1RU49 (Actinin alpha 3)

F1MJQ3 (alpha amylase)

A7YWG4 (gamma-glutamyl hydrolase)

E1BH94 (peptidoglycan recognicion protein 2)

Q58CQ9 (Pantetheinase)

F1MVK1 (uncharacterized protein)

A5PKC2 (SHBG protein)

A0A287AY54 (60S acidic ribosomal protein)

G5E5T5 (Ig-like domain containing protein)

A5PK77 (Serpin A11 protein)

P56652 (ITIH-3)

F1MMD7 (ITIH-4)

F1MJK3 (Pregnancy zone protein)

–

Serum-coated PS100 (−)

A0A287AFA5 (Ras homolog member F)

–

–

Serum-coated PS 1000

P33072 (Protein-lysine-6-oxidase)

P35445 (Cartilage oligomeric matrix protein)

F1SHM0 (pyruvate kinase M1/2)

Q2KIT0 (Protein HP20-homolog)

P19879 (Mimecan)

I3LQ84 (Collagen type 6 alpha 2 chain)

P07224 (Vitamin K dependent protein S)

Q5E946 (Parkinson disease protein 7 homolog)

F1N0I3 (Coagulation factor 5)

Digested+serum-coated PS 100

F1N5M2 (Vitamin D binding protein)

Q32KY0 (apolipoprotein D)

A0A3Q1MFR4 (Apolipoprotein B)

P15497 (Apolipoprotein A-1)

A0A3Q1M1Z4 (Ig-like domain containing protein)

–

Digested+serum-coated PS 100(+)

E1B9F6 (Elongation factor 2-alpha)

F1SML4 (SND-domain containing) protein)

Q29375 (Large ribosomal subunit eL8)

A0A5G2QSB4 (ribosomal protein S3)

P01846 (Ig lambda chain C region)

K7GLN4 (Peroxyredoxin 4)

F2Z4Y8 (40S ribosomal protein S11)

P28839 (cytosol aminopeptidase)

Q29036 (DAD-1)

A0A5G2Q9S0 (Nucleoside diphosphatase kinase)

F1SQT3 (mitochondrial phosphate carrier protein)

A0A287A014 (40S ribosomal protein S15a)

A0A5G2R5F8 (KDEL endoplasmic reticulum protein retention receptor)

F1SQW6 (endoplasmic reticulum protein 27)

P80021 (ATP synthase mitochondrial subunit)

A0A286ZKG9 (Peptidyl-prolyl cis–trans isomerase)

A0A286ZW72 (60S ribosomal protein L14)

P26779 (Proaposin)

K7GNY4 (60S ribosomal protein L8)

F1RW28 (hydroxysteroid 17-beta dehydrogenase)

F1SFA7 (collagen type 1 alpha 2 chain)

Digested+serum-coated PS 100(−)

A0A287AYH9 (Palmtioyl-protein thioesterase 1)

F1MZ96 (Ig-like domain containing protein)

G3MYZ3 (Afamin)

Digested+serum-coated PS 1000

G3N0S9 (Sushi domain containing protein)

–

–

  1. This table highlights differentially abundant proteins which were only enriched on one single particle treatment combination. The leftmost column shows the corresponding particle and treatment while the 3 rightmost columns indicate the Uniprot identified and full name of the identified protein