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Table 7 Proteins showing a significant correlation with PS MNP uptake

From: The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages

Protein ID

Protein name

R-coefficient

P value

upregulated in

Fig.  9 label

P81644

Apolipoprotein A-II

0.90

0.002

Digested+serum-coated PS100

Digested+serum-coated PS100 (−)

Serum-coated PS100 (+)

1

A0A3Q1MGI2

Apolipoprotein E

0.85

0.007

–

2

P19034

Apolipoprotein C-II

0.82

0.012

Serum-coated PS100 (+) Serum-coated PS1000

3

P02081

Hemoglobin fetal subunit beta

0.81

0.014

–

4

P02639

Protein S100-A1

0.80

0.015

Serum-coated PS100 (+) Serum-coated PS1000

5

A0A5G2QL09

S-adenosylmethionine synthase

0.77

0.026

Serum-coated PS100 (+) Serum-coated PS1000

6

G3MZI7

Collagen type V alpha 1 chain

− 0.76

0.030

Serum-coated PS100

7

P01965/P01966

Hemoglobin subunit alpha

0.75

0.033

All

8

P62833

Ras-related protein Rap-1A

0.75

0.034

–

9

Q3ZBS7

Vitronectin

0.73

0.041

–

10

Q58D62

Fetuin-B

− 0.72

0.043

–

11

P19879

Mimecan

0.71

0.049

Serum-coated PS1000

12

Q3MHN5

Vitamin D-binding protein

0.68

0.061

Digested+serum-coated PS100

Digested+serum-coated PS100 (+)

13

Q28035

Glutathione S-transferase A1

0.66

0.076

Serum-coated PS100 (+)

Serum-coated PS1000

14

F1SHM0

pyruvate kinase M1/2

0.66

0.076

Serum-coated PS1000

15

A0A286ZNV2

Elongation factor 1-alpha 2

0.64

0.089

Digested+serum-coated PS100

Digested+serum-coated PS100 (+)

16

P33072

Protein-lysine 6-oxidase

0.64

0.090

Serum-coated PS1000

17

F1N1W7

Neural cell adhesion molecule 1

− 0.63

0.096

Serum-coated PS100 Serum-coated PS100 (+) Serum-coated PS100 (−)

18

P01035

Cystatin-C

0.62

0.103

Serum-coated PS100 (−)

Serum-coated PS1000

19

Q9TTE1

Serpin A3-1

− 0.61

0.109

–

20

P15497

Apolipoprotein A-I

0.59

0.124

Digested+serum-coated PS100

21

P07224

Vitamin K-dependent protein S

− 0.58

0.130

Serum-coated PS1000

22

A0A287AK65

Argininosuccinate synthase

0.58

0.136

Serum-coated PS100 (+) Serum-coated PS1000

23

F1N0I3

Coagulation factor V

0.57

0.138

Serum-coated PS1000

24

F1N102

Complement C8 beta chain

0.57

0.140

All serum-coated MNPs

25

G5E513

Ig-like domain-containing protein

− 0.57

0.142

–

26

Q3SZV7

Hemopexin

− 0.56

0.148

–

27

A0A3Q1M1Z4

Ig-like domain-containing protein

− 0.55

0.155

Digested+serum-coated PS100

28

P80012

von Willebrand factor

− 0.55

0.157

Serum-coated PS100

29

P10096

Glyceraldehyde-3-phosphate dehydrogenase

0.54

0.163

–

30

A0A3Q1M3L6

Ig-like domain-containing protein

− 0.54

0.165

Serum-coated PS100, Serum-coated PS100 (−) Serum-coated PS1000

31

Q5E946

Parkinson disease protein 7 homolog

0.54

0.167

Serum-coated PS1000

32

Q2KIT0

Protein HP-20 homolog

0.53

0.177

Serum-coated PS1000

33

F1SUP2

Signal peptidase complex subunit 2

− 0.53

0.180

Digested+serum-coated PS100

Digested+serum-coated PS100 (+)

34

P00735

Prothrombin

0.52

0.187

Serum-coated PS100

35

E1B805

Complement C3

− 0.52

0.190

Serum-coated PS100

Serum-coated PS100 (−) Serum-coated PS1000

36

A0A3Q1MFR4

Apolipoprotein B

− 0.51

0.191

Digested+serum-coated PS100

37

P81947

Tubulin alpha-1B chain

0.51

0.195

–

38

F1MW44

Coagulation factor XIII A chain

0.51

0.200

Serum-coated PS100

39

P02676

Fibrinogen beta chain

0.50

0.206

Serum-coated PS100 Serum-coated PS100 (+)

40

  1. The columns show the UniProt protein IDs and protein names of all of the proteins that were found to be correlated with MNP uptake. Correlation was defined as having an absolute Pearson correlation coefficient (R) > 0.5, with a positive R-coefficient indicating a positive correlation and a negative R-coefficient indicating an inverse correlation. The table is ordered from highest absolute correlation to lowest absolute correlation. The enriched in the column indicates whether the protein was enriched in any of the particle treatment combinations (Additional file 2). The numbers in the last column provide a link to the x-axis label in Fig. 9
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Particle and Fibre Toxicology

ISSN: 1743-8977

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