Fig. 2

Genes implicated in mesothelioma or mesothelioma formation. A Thirty-eight differentially expressed genes (DEGs) that showed consistent expression changes across the rat transcriptome datasets, regardless of inducer or tumor type. Overlay gene expressions (fold changes) represent those of MWCNT C. B The same set of genes is overlaid with gene expressions (fold changes) from the dataset GSE51024, which pertains to human malignant pleural mesotheliomas. Genes were filtered by fold change < − 1.5 or > 1.5, ANOVA P < 0.05, and FDR P < 0.05. Red (upregulated), green (downregulated), gray (did not meet at least one filter), orange (predicted activation)