Fig. 3

Bioinformatic analyses of tumor transcriptomes induced by MWCNTs and amosite asbestos using Ingenuity Pathway Analysis (IPA). A Graphical summary obtained by Core Analysis of the MWCNT B transcriptome dataset. The summary shows a relationship of a subset of the most significant entities predicted in the analysis, which include canonical pathways, upstream regulators, diseases, and biological functions. IPA graph legends: orange (activation); blue (inhibition); solid line (direct interaction); dashed line (indirect interaction); dotted line (inferred edge); for signaling pathways: an arrow pointing from A to B signifies that A causes B to be activated. B After conducting Comparative Analysis, shown are highly-scoring predicted canonical pathways in the datasets as classified by inducers. Heat maps depict z-scores, in which orange (positive z-score) represents activation. The canonical pathways are sorted by hierarchical clustering and z-scores. The column clusters represent the inducers