Fig. 1
(a) Stacked column plots representing non-aerated lung volumes (NALV) (ml) and aerated lung volumes (ALV) (ml) [resulting in total lung volumes (TLV) (ml)] in C57BL/6J and NOD/ShiLtJ mice. Data are presented as mean ± SD. Experimental groups were compared using repeated measures Two-Way ANOVA or mixed model in case of missing values with Tukey correction for multiple testing. Significant differences are represented as follows: $p < 0.05 between ALV, # p < 0.05 between NALV. N = 7–9 mice/group. (b) Mean aerated lung volume (HU) in DEP, silica, silica + DEP and vehicle exposed C57BL/6 and NOD/ShiLtJ mice. Data are presented as individual values with mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 by repeated measures Two-way ANOVA or mixed model in case of missing values with Tukey correction. N = 7–9 mice/group. (c) Forced vital capacity (FVC), Forced Expiratory Capacity in 0.1 s (FEV0.1) and Tissue Damping (G) in DEP, silica, silica + DEP and vehicle exposed C57BL/6 and NOD/ShiLtJ mice. Data are represented as individual values with mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 by One-way ANOVA with Tukey correction. N = 5–9 mice/group