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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure

Fig. 3

ACRE-DEP induces alveolar epithelial and microvascular endothelial antioxidant expression. A mRNA expression, determined by qPCR, of HMOX1, NQO1, and GCLM in epithelial, endothelial, and pMVEC donors over a 4–24 h ACRE-DEP exposure. B, C Protein expression and densitometry of HMO1, NQO1, GCLM, and GAPDH or vinculin (loading controls) in the B epithelial cells and C endothelial cells over a 2–24 h ACRE-DEP exposure. A–C Values represent the mean of n = 3 independent experiments ± SD and immunoblots are representative images from n = 3 independent experiments. Statistically significant differences between vehicle and ACRE-DEP treated cells are indicated by *p ≤ 0.05, **p ≤ 0.01, and ****p ≤ 0.0001

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Particle and Fibre Toxicology

ISSN: 1743-8977

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