Table 5 Correlation coefficients of equivalent dose non-LPS stimulated THP-1 cells versus C57Bl/6J BALF (300 µg) at Day 1 and 7 post-exposure for 16 pro-inflammatory cytokines

24 h 0.6 µg/cm² versus Day 1 300 µg/lung

r

0.16

n/a

n/a

n/a

p value

0.56

–

–

–

24 h 6 µg/cm² versus Day 1 300 µg/lung

r

− 0.07

0.88^a

n/a

n/a

p value

0.81

0.001

–

–

24 h 0.6 µg/cm² versus Day 7 300 µg/lung

r

0.33

n/a

n/a

n/a

p value

0.21

–

–

–

24 h 6 µg/cm² versus Day 7 300 µg/lung

r

− 0.15^a

0.38^a

n/a

n/a

p value

0.58

0.14

–

–