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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis

Fig. 4

In situ visualization of critical metabolites and metabolic enzymes in arginine and proline metabolism changed by CQDs in brain of mice. (a) MSI and H&E overlay images or MS images and levels of spermidine and spermine in different regions of brain; (b) SMS-mediated metabolic process of converting spermidine to spermine; (c) The newly constructed MSI based on the ion intensity ratio of converting spermidine to spermine; (d, e) Representative IHC staining showed the expression of SMS in different regions of brain tissue section and its IHC score. Olfactory bulb (OB), Cortex (COR), Hippocampus (HIP), Corpus Striatum (CS), Midbrain (MB), Cerebellum (CE), Nucleus Accumbens (NAcc), Lateral Habenula Nucleus (LHB) and Zona Incerta (ZI). Data are showed as mean ± SD of three independent experiments. (*P < 0.05, **P < 0.01, ***P < 0.001)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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