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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis

Fig. 9

CQDs caused PD-like degeneration in mice. (a) Representative IHC staining images and quantitative results of TH positive cells in SNpc and TH positive terminals in striata; (b) Representative track and heatmap images in the open-field test, and the quantitative results of parameter analysis including total moved distance (c) and time spent in center (d); (e) The time to fall in suspension test; (f, g) The time to orient down and time to descend in pole-climbing test; (h) The scores of swim test. Data are showed as mean ± SD of three independent experiments. (*P < 0.05, **P < 0.01, ***P < 0.001)

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