Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants

Table 3 Dose–response relationship between levels of personal air pollutants exposure and DNA methylation in the participants

Repetitive element		Study 1 associations with metal-rich particulate matter (PM ₁₀)		Study 2 associations with air benzene		Study 3 associations with traffic-derived elemental carbon
Family	Subfamily	τ ^a	p value	τ ^a	p value	τ ^a	p value
	L1PA5	-15.2	0.02^*	-2.3	0.28	5.6	0.01^*
LINE-1	L1PA2	-5.8	0.03^*	-4.3	0.01^*	-2.3	0.51
	L1Hs	1.4	0.68	1.0	0.60	-2.7	0.19
	L1Ta	-4.2	0.17	0.7	0.74	1.6	0.68
	Alu Sx	0.0	1.00	1.0	0.21	0.0	1.00
*Alu*	Alu Yb8	-3.8	0.11	-0.4	0.74	2.4	0.14
	Alu Yd6	-6.6	0.31	-4.1	0.37	4.0	0.29
	MLT1D	-47.6	0.16	54.6	0.13	-41.8	0.09
HERV	ERV1	0.4	0.78	0.6	0.56	0.0	0.99
	ERV9	1.9	0.45	1.4	0.42	0.5	0.83

^a τ = (2^β - 1) * 100 represents the percent-change of the ratio methylated/unmethylated associated with an increase in the exposure from the 25th to the 75th percentile, adjusted for age and smoking.
^* p< 0.05.

ISSN: 1743-8977