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Table 3 In vivo expression of genes encoding junction proteins a

From: Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia

 

CLDN2

CLDN3

CLDN5

OCLN

TJP1

TJP2

Ileum Ctl

1.02 ± 0.17

1.07 ± 0.39

1.05 ± 0.33

1.03 ± 0.23

1.08 ± 0.39

1.06 ± 0.33

Ileum NP

0.74 ± 0.37*

1.26 ± 0.60*

1.64 ± 1.07

0.72 ± 0.32*

1.54 ± 0.58*

1.27 ± 0.53*

Colon Ctl

n/a

1.02 ± 0.19

n/a

n/a

1.11 ± 0.06

1.01 ± 0.16

Colon NP

n/a

0.61 ± 0.16

n/a

n/a

0.75 ± 0.16

0.69 ± 0.18

  1. aRelative expression of genes encoding proteins involved in cell junction maintenance, measured in the ileum and colon of control mice (not exposed to NPs) and mice exposed to a single gavage of 12.5 mg of TiO2-NP/kgbw and sacrificed after 6 h, n/a not measured. Results are the average of 6 replicates ± standard deviation. Statistical significance was examined by randomization tests using REST2009 [37].