Dosimetry and short term retention of TiO
for single high dose TiO
exposure. The mass of TiO2 deposited in the lung following whole body inhalation (blue squares) and intratracheal instillation (green circles) was determined immediately, 24 hr and 7 days post exposure (A) and the compartmentalization of TiO2 in BALF supernatant, BALF cell pellet and the remaining lung tissue after lavage (lavaged lung) were determined 24 hr post exposure (B). Values are group means (n = 3–5) ± standard error (SE). The inhalation and instillation ILBs were not found to be significantly different; *, significantly different compared to the respective ILB (p < 0.05).