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Table 2 Tissue distribution of 65 Zn at 7 days after intratracheal instillation of 65 ZnO or SiO 2 -coated 65 ZnO NPs in rats

From: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

 

65ZnO

SiO2-coated65ZnO

 

Mean ± SE

Mean ± SE

Lungs

1.90 ± 0.18

1.05 ± 0.04

Blood

2.13 ± 0.05*

1.79 ± 0.07

Lymph nodes

0.18 ± 0.02

0.31 ± 0.05 #

Bone marrow

3.70 ± 0.28

3.38 ± 0.16

Bone

12.12 ± 0.53

12.21 ± 0.84

Skin

10.02 ± 0.49

10.55 ± 0.80

Brain

0.25 ± 0.01

0.27 ± 0.01

Skeletal muscle

19.81 ± 0.84*

8.34 ± 3.45

Testes

1.27 ± 0.06

1.23 ± 0.03

Kidneys

0.75 ± 0.03

0.69 ± 0.02

Spleen

0.21 ± 0.01

0.20 ± 0.01

Heart

0.27 ± 0.01*

0.23 ± 0.01

Liver

5.80 ± 0.13*

5.19 ± 0.25

Stomach

0.66 ± 0.02

0.66 ± 0.03

Small intestine

2.83 ± 0.10

2.53 ± 0.12

Large intestine

0.84 ± 0.07

0.83 ± 0.05

Cecum

1.15 ± 0.06

1.04 ± 0.09

Total recovered

81.33 ± 6.51*

69.91 ± 3.33

  1. Data are mean ± SE% instilled dose, n = 8/group.
  2. Total recovered = sum of 65Zn in analyzed organs, feces and urine.
  3. *P < 0.05, ZnO > SiO2-coated ZnO.
  4. # P <0.05, SiO2-coated ZnO > ZnO.