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Table 2 Tissue distribution of 65 Zn at 7 days after intratracheal instillation of 65 ZnO or SiO 2 -coated 65 ZnO NPs in rats

From: Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles

  65ZnO SiO2-coated65ZnO
  Mean ± SE Mean ± SE
Lungs 1.90 ± 0.18 1.05 ± 0.04
Blood 2.13 ± 0.05* 1.79 ± 0.07
Lymph nodes 0.18 ± 0.02 0.31 ± 0.05 #
Bone marrow 3.70 ± 0.28 3.38 ± 0.16
Bone 12.12 ± 0.53 12.21 ± 0.84
Skin 10.02 ± 0.49 10.55 ± 0.80
Brain 0.25 ± 0.01 0.27 ± 0.01
Skeletal muscle 19.81 ± 0.84* 8.34 ± 3.45
Testes 1.27 ± 0.06 1.23 ± 0.03
Kidneys 0.75 ± 0.03 0.69 ± 0.02
Spleen 0.21 ± 0.01 0.20 ± 0.01
Heart 0.27 ± 0.01* 0.23 ± 0.01
Liver 5.80 ± 0.13* 5.19 ± 0.25
Stomach 0.66 ± 0.02 0.66 ± 0.03
Small intestine 2.83 ± 0.10 2.53 ± 0.12
Large intestine 0.84 ± 0.07 0.83 ± 0.05
Cecum 1.15 ± 0.06 1.04 ± 0.09
Total recovered 81.33 ± 6.51* 69.91 ± 3.33
  1. Data are mean ± SE% instilled dose, n = 8/group.
  2. Total recovered = sum of 65Zn in analyzed organs, feces and urine.
  3. *P < 0.05, ZnO > SiO2-coated ZnO.
  4. # P <0.05, SiO2-coated ZnO > ZnO.