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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

Fig. 7

Endothelial cell interaction with ECM. Barrier function is maintained by endothelial cells inter-cellular interactions and adherence to ECM. Occludin, claudins, and junctional adhesion molecules (JAMs) comprise the tight junctions, while VE-cadherin interactions stabilize adherens junctions. Connexins develop gap junctions. Junctional stability is intracellularly maintained by linking with the actin cytoskeleton intermediated by catenins (e,g, β-catenin, α-catenin; γ-catenin;) or zona occluden-1 protein. Endothelial cells interact with ECM matrix protein (fibronectin or vitronectin) through integrin receptors. Proteins like talin and vinculin link integrins’ cytosolic domains with actin cytoskeleton, these proteins are also involved in integrin-mediated signaling

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Particle and Fibre Toxicology

ISSN: 1743-8977

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