Fig. 6

Effects of AgNP exposure on rat venous thrombosis model in vivo. The freshly isolated RBCs from rats were treated with various concentrations of AgNP for 4 h. a PS exposure and (b) thrombin generation (n = 4) were evaluated as described in methods. c Blood was collected to determine rat ex vivo PS exposure on RBCs 2 h after intravenous injection of saline (control, n = 6) or AgNP (10 mg/kg, n = 7 or 50 mg/kg, n = 5). d 2 h after intravenous injection of saline (control, n = 6) or AgNP (10 or 50 mg/kg, n = 8 for each dose), thrombus formation was induced by the infusion of thromboplastin in a rat venous thrombosis model. Values are mean ± S.E. of 4–8 independent experiments, * represents significant differences from control group (p < 0.05)