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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice

Fig. 9

Examples of observed histopathological findings in lungs. Light photomicrographs of G11, small-diameter, distal axial airway from the lungs of PBS-treated mice (a, b), OVA-treated mice (c, d) and OVA+TiO2 NP treated mice (e, f). Lung tissue sections for a, c and e were stained for murine major basic protein, a specific marker for eosinophils (red chromogen-stained cells; arrow 1). Tissue sections b, d and f were stained with Alcian Blue/Periodic Acid Schiff (AB/PAS) for neutral and acidic mucosubstances (dark magenta stain; arrow 2) in mucous cells of the airway epithelium (e). aa: axial airway lumen; bv: blood vessel; a: alveolus; arrow 3:mononuclear cell infiltrate (mainly lymphoid); arrow 4: TiO2 NP-laden alveolar macrophages

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Particle and Fibre Toxicology

ISSN: 1743-8977

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