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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Fig. 3

nanoSiO2 promotes mitochondrial membrane permeability associated to mPTP opening. a-b Representative recordings of mitochondrial CRC at increasing concentrations: (a) as a function of nanoSiO2, and (b) as a function of CsA. Arrows represent 10 μM Ca2+ bolus addition. c-d Semiquantitative analysis of CRC: (c) as a function of nanoSiO2, and (d) as a function of CsA. e-f Representative recordings of: (e) mitochondrial depolarization, and (f) swelling in presence and absence of CsA. The exposure of mitochondria to nanoSiO2 was 5 min prior to measurements. The concentration of nanoSiO2 in (b,d-f) was 100 μg/mL. CsA was applied at the same time of nanoSiO2 administration. Values are percentage of control and represent mean ± SEM

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Particle and Fibre Toxicology

ISSN: 1743-8977

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