Skip to main content
Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Fig. 5

Retained [105Ag]Ag activity fractions after intratracheal inhalation of [105Ag]AgNP in organs and tissues investigated up to 28 days p.e. Panel a: total translocation, blood and carcass; b: liver, spleen, and kidneys; Panel c: heart, brain, and uterus;. The vertical axis of all four panels is given on a log scale. The mean ILD in mass (number) of [105Ag]AgNP of all five retention time points is 25.6 ± 6.9 μg (7.94 ± 3.24•1011 #). [105Ag]Ag activity retention is given as fractions of the initial lung dose (ILD) corrected for [105Ag]Ag in the residual blood. Data in all panels correspond to the first line (corr. Resid. blood) of each organ or tissue in Table 4. Mean ± SEM, n = 4 rats per time-point. Data points of both groups of rats at 0.75 and 24 h are set slightly aside from each other for easier distinction of the highly reproducible data obtained. Statistical one-way ANOVA analysis with the post-hoc Bonferroni test in between all time-points are given in the matrix below

Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us