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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Fig. 7

[105Ag]Ag activity accumulation in secondary organs and tissues between0.75 h and 28 days after intratracheal inhalation of [105Ag]AgNP normalized to the total 105Ag activity translocated across the ABB. Panel a: liver spleen and kidneys; Panel b: heart, brain, uterus; Panel c: carcass, blood. The data are corrected for [105Ag]Ag activity retained in the residual blood volume of organs and tissues. The mean ILD in mass (number) of [105Ag]AgNP of all five retention time points is 25.6 ± 6.9 μg (7.94 ± 3.24•1011 #). Mean ± SEM, n = 4 rats per time point. Data points for both groups of rats at 0.75 and 24 h are set slightly apart from each other for easier distinction of the highly reproducible data obtained. The table below shows the statistical one-way ANOVA analysis with the post-hoc Bonferroni test between all time-points

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Particle and Fibre Toxicology

ISSN: 1743-8977

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