Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Table 5 urinary and fecal excretion 24 h after either IV injection or IT instillation of solutions of ¹⁹²Ir, ⁴⁸V, ¹⁹⁸Au, and ^110mAg ions

Ionic solutions	24 h excretion	Fraction of applied ions	Ratio urine/feces	Fraction of applied ions	Ratio urine/feces
		IV	IV	IT	IT
¹⁹²Ir-ions	GIT + feces	0.007 ± 0.012		0.062 ± 0.019
¹⁹⁸Au-ions	GIT + feces	0.059 ± 0.006		0.201 ± 0.029
⁴⁸V-ions	GIT + feces	0.088 ± 0.041		0.119 ± 0.020
^110mAg-ions	GIT + feces	0.873 ± 0.009		0.699 ± 0.062
¹⁹²Ir-ions	urine	0.277 ± 0.013	41.26	0.426 ± 0.112	6.911
¹⁹⁸Au-ions	urine	0.087 ± 0.031	1.472	0.07 ± 0.01	0.350
⁴⁸V-ions	urine	0.365 ± 0.077	4.127	0.319 ± 0.055	2.672
^110mAg-ions	urine	0.005 ± 0.006	0.006	0.009 ± 0.014	0.013

Comparison of fractional urinary and fecal excretions 24 h after IV injection and IT instillation of soluble ¹⁹²Ir-ions [28], ⁴⁸V-ions [30], ¹⁹⁸Au-ions [25] and [^110mAg]Ag ions (cf. Figure 1) applied in the auxiliary studies in the present work. Note, in the data of 24 h fecal excretion, the 24 h GIT fractions are added due to the delayed passage through the GIT into feces. Data are given as mean ± SD, n ≥ 4 rats per group.

ISSN: 1743-8977