Table 2 The Ag content (in mg per kg of tissue) in heart, brain, liver and kidney, blood and reproductive organs and gastrointestinal tract of male and female rats after administration of LD and HD of PVP-AgNPs
Tissue | Males | Females | ||||
|---|---|---|---|---|---|---|
Ctl | LD | HD | Ctl | LD | HD | |
Blood | 0.01 ± 0.00 | 5.63 ± 2.11 | 19.02 ± 1.12* | 0.01 ± 0.00 | 3.62 ± 0.81 | 49.31 ± 7.55§ |
Liver | 0.03 ± 0.02 | 0.10 ± 0.08 | 0.20 ± 0.04 | 0.01 ± 0.00 | 0.05 ± 0.01 | 0.41 ± 0.05*§ |
Kidney | 0.02 ± 0.00 | 0.08 ± 0.03 | 0.23 ± 0.4 | 0.02 ± 0.00 | 0.06 ± 0.02 | 0.75 ± 0.04§ |
Heart | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.05 ± 0.00§ |
Brain | 0.01 ± 0.00 | 0.16 ± 0.11 | 0.25 ± 0.01 | 0.01 ± 0.00 | 0.04 ± 0.01 | 0.28 ± 0.02* |
Stomach | 0.01 ± 0.00 | 0.03 ± 0.01 | 0.15 ± 0.04* | 0.02 ± 0.03 | 0.11 ± 0.00 | 2.26 ± 1.76*§ |
Duodenum | 0.01 ± 0.00 | 0.03 ± 0.01 | 0.05 ± 0.01 | 0.01 ± 0.00 | 0.04 ± 0.03 | 0.61 ± 0.47*§ |
Jejunum | 0.01 ± 0.00 | 0.07 ± 0.05 | 0.16 ± 0.07 | 0.01 ± 0.00 | 0.01 ± 0.00 | 4.12 ± 3.64 |
Ileum | 0.01 ± 0.00 | 0.03 ± 0.01 | 0.06 ± 0.03 | 0.01 ± 0.00 | 0.02 ± 0.00 | 0.09 ± 0.03 |
Cecum | 0.01 ± 0.00 | 0.16 ± 0.08 | 0.68 ± 0.40 | 0.01 ± 0.00 | 0.05 ± 0.03 | 5.15 ± 1.15 |
Colon | 0.01 ± 0.00 | 0.52 ± 0.47 | 1.42 ± 0.57 | 0.01 ± 0.00 | 0.02 ± 0.01§ | 3.37 ± 0.32* |
Testis | 0.01 ± 0.00 | 0.04 ± 0.02 | 0.13 ± 0.01* | n.a | n.a | n.a |
Epididymis | 0.01 ± 0.00 | 0.18 ± 0.17 | 0.27 ± 0.04 | n.a | n.a | n.a |
Ovary | n.a | n.a | n.a | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.13 ± 0.03 |