Table 1 Overview of findings per test groups upon 28-day oral gavage administration of the respective nanomaterials

Body weight: day 28 (g)

Mean: 286.2

SD: 27.5

Mean: 294.5

SD: 18.1

Mean: 296.1

SD: 21.8

p value: 0.5868^a

p value: 0.5451^a

Hematology: RBC (tera/L)

Mean: 7.94

SD: 0.24

Mean: 8.27

SD: 0.46

Mean: 8.4

SD: 0.21

p value: 0.2222^b

p value: 0.0317^b

Hematology: RET (%)

Mean: 2.2

SD: 0.3

Mean: 2.1

SD: 0.3

Mean: 1.7

SD: 0.3

p value: 0.8413^b

p value: 0.0397^b

Hematology: MCHC (mmol/L)

Mean: 20.58

SD: 0.07

Mean: 20.81

SD:0.38

Mean: 20.41

SD: 0.12

p value: 0.2222^b

p value: 0.0317^b

Hematology: Eos. (%)

Mean: 1.5

SD: 0.5

Mean: 1

SD: 0.3

Mean: 1.7

SD: 0.5

p value: 0.0238^b

p value: 0.4127^b

Clinical chemistry: Hapt. (ng/mL)

Mean: 234.02

SD: 103.09

Mean: 413.56

SD: 198.9

Mean: 287.83

SD: 179.12

p value: 0.0476^c

p value: 0.4206^c

Urine-analysis

Various data sets

Not sign. different from control

Not sign. different from control

Relative liver weights (g)

Mean: 2.445

SD: 0.108

Mean: 2.706

SD: 0.117

Mean: 2.586

SD: 0.142

p value: 0.0159^b

p value: 0.1508^b

Relative organ weights

Various data sets

Not sign. different from control

Not sign. different from control

Gross lesions

Discolouration of the content of the glandular stomach, jejunum, cecum, and/or colon

Histopathology

Various data sets

Not sign. different from control

Not sign. different from control