A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence

Table 2 Summary of the AOP of cardiovascular system

Sequence	Type	Event ID	Title	Short name
1	MIE	1115	ROS generation	Increased, Reactive oxygen species
2	MIE	151	Inflammatory pathways Activation	Inflammatory pathways Activation
3	KE	1392	Oxidative stress	Oxidative stress
4	KE	1239	Altered gene expression	Altered, Gene Expression
5	KE	177	Mitochondrial dysfunction	Mitochondrial dysfunction
6	KE	1445	lipid peroxidation	Increase, LPO
7	KE	1918	Myocardial apoptosis	Myocardial apoptosis
8	KE	1927	Vascular endothelial cell autophagy dysfunction	Vascular endothelial cell autophagy dysfunction
9	KE	1994	Increase, Ferroptosis	Ferroptosis
10	KE	149	Inflammatory response	Increase, Inflammation
11	KE	1496	Secretion of inflammatory factors	Increased proinflammatory mediators
12	KE	1919	Cardiac dysregulation	Cardiac dysfunction
13	KE	1924	Cardiac fibrosis	Cardiac fibrosis
14	KE	1928	Vascular endothelial dysfunction	Vascular endothelial dysfunction
15	AO	1929	Increased morbidity and mortality of cardiovascular disease	Increased morbidity and mortality of cardiovascular disease

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