Table 5 Summary of the AOP of reproductive system
Sequence | Type | Event ID | Title | Short name |
|---|---|---|---|---|
1 | MIE | 1115 | ROS generation | Increased, Reactive oxygen species |
2 | MIE | 151 | Inflammatory pathways Activation | Inflammatory pathways Activation |
3 | KE | 1392 | Oxidative stress | Oxidative stress |
4 | KE | 1815 | Activation of ER stress | ER stress |
5 | KE | 1945 | Dysfunctional autophagy | Dysfunctional Autophagy |
6 | KE | 177 | Mitochondrial dysfunction | Mitochondrial dysfunction |
7 | KE | 149 | Inflammatory response | Increase, Inflammation |
8 | KE | 1496 | Secretion of inflammatory factors | Increased proinflammatory mediators |
9 | KE | 1758 | Impaired Spermatogenesis | Impaired, Spermatogenesis |
10 | KE | 1837 | Decreased oocyte maturation | Decreased oocyte maturation |
11 | AO | 520 | Decreased sperm quantity or quality | Decreased sperm quantity or quality |
12 | AO | 363 | Altered reproductive behaviour | Altered, Reproductive behaviour |