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  1. Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties of MWCNTs need to be identified. Functionalization...

    Authors: Alexia J. Taylor-Just, Mark D. Ihrie, Katherine S. Duke, Ho Young Lee, Dorothy J. You, Salik Hussain, Vamsi K. Kodali, Christina Ziemann, Otto Creutzenberg, Adriana Vulpoi, Flaviu Turcu, Monica Potara, Milica Todea, Sybille van den Brule, Dominique Lison and James C. Bonner

    Citation: Particle and Fibre Toxicology 2020 17:60

    Content type: Research

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  2. Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects o...

    Authors: Hsiao-Chi Chuang, Hsin-Chang Chen, Pei-Jui Chai, Ho-Tang Liao, Chang-Fu Wu, Chia-Ling Chen, Ming-Kai Jhan, Hui-I Hsieh, Kuen-Yuh Wu, Ta-Fu Chen and Tsun-Jen Cheng

    Citation: Particle and Fibre Toxicology 2020 17:59

    Content type: Research

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  3. Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies.

    Authors: Lauren H. Wyatt, Robert B. Devlin, Ana G. Rappold, Martin W. Case and David Diaz-Sanchez

    Citation: Particle and Fibre Toxicology 2020 17:58

    Content type: Research

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  4. Fetal development is a crucial window of susceptibility in which exposure may lead to detrimental health outcomes at birth and later in life. The placenta serves as a gatekeeper between mother and fetus. Knowl...

    Authors: Eva Bongaerts, Tim S. Nawrot, Thessa Van Pee, Marcel Ameloot and Hannelore Bové

    Citation: Particle and Fibre Toxicology 2020 17:56

    Content type: Review

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  5. Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk...

    Authors: Sara B. Fournier, Jeanine N. D’Errico, Derek S. Adler, Stamatina Kollontzi, Michael J. Goedken, Laura Fabris, Edward J. Yurkow and Phoebe A. Stapleton

    Citation: Particle and Fibre Toxicology 2020 17:55

    Content type: Research

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  6. Information on particle deposition, retention, and clearance is important when evaluating the risk of inhaled nanomaterials to human health. The revised Organization Economic Cooperation and Development (OECD)...

    Authors: Hoi Pin Kim, Jin Kwon Kim, Mi Seong Jo, Jung Duck Park, Kangho Ahn, Mary Gulumian, Günter Oberdörster and Il Je Yu

    Citation: Particle and Fibre Toxicology 2020 17:54

    Content type: Research

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  7. Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the ph...

    Authors: Xiaoli Feng, Yaqing Zhang, Chao Zhang, Xuan Lai, Yanli Zhang, Junrong Wu, Chen Hu and Longquan Shao

    Citation: Particle and Fibre Toxicology 2020 17:53

    Content type: Review

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  8. While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier. In...

    Authors: Timothy Smyth, Janelle Veazey, Sophia Eliseeva, David Chalupa, Alison Elder and Steve N. Georas

    Citation: Particle and Fibre Toxicology 2020 17:52

    Content type: Research

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  9. Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80–90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos,...

    Authors: Dina Mourad Saleh, William T. Alexander, Takamasa Numano, Omnia Hosny Mohamed Ahmed, Sivagami Gunasekaran, David B. Alexander, Mohamed Abdelgied, Ahmed M. El-Gazzar, Hiroshi Takase, Jiegou Xu, Aya Naiki-Ito, Satoru Takahashi, Akihiko Hirose, Makoto Ohnishi, Jun Kanno and Hiroyuki Tsuda

    Citation: Particle and Fibre Toxicology 2020 17:48

    Content type: Research

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  10. Titanium dioxide (TiO2) is broadly used in common consumer goods, including as a food additive (E171 in Europe) for colouring and opacifying properties. The E171 additive contains TiO2 nanoparticles (NPs), part o...

    Authors: A. Guillard, E. Gaultier, C. Cartier, L. Devoille, J. Noireaux, L. Chevalier, M. Morin, F. Grandin, M. Z. Lacroix, C. Coméra, A. Cazanave, A. de Place, V. Gayrard, V. Bach, K. Chardon, N. Bekhti…

    Citation: Particle and Fibre Toxicology 2020 17:51

    Content type: Research

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  11. The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confir...

    Authors: Ru Ma, Yi Qi, Xinying Zhao, Xueyan Li, Xuejing Sun, Piye Niu, Yanbo Li, Caixia Guo, Rui Chen and Zhiwei Sun

    Citation: Particle and Fibre Toxicology 2020 17:50

    Content type: Research

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  12. Exposure to particulate matter (PM) from wood combustion represents a global health risk, encompassing diverse exposure sources; indoor exposures due to cooking in developing countries, ambient PM exposures fr...

    Authors: Carley Schwartz, Anette Kocbach Bølling and Christopher Carlsten

    Citation: Particle and Fibre Toxicology 2020 17:49

    Content type: Review

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  13. Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the...

    Authors: Jinglong Tang, Wenting Cheng, Jinling Gao, Yanting Li, Ruyong Yao, Nathaniel Rothman, Qing Lan, Matthew J. Campen, Yuxin Zheng and Shuguang Leng

    Citation: Particle and Fibre Toxicology 2020 17:47

    Content type: Research

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  14. With the development of zinc oxide nanoparticles (ZnO NPs) in the field of nanotechnology, their toxicological effects are attracting increasing attention, and the mechanisms for ZnO NPs neurotoxicity remain o...

    Authors: Zixuan Liu, Xuying Lv, Lei Xu, Xuting Liu, Xiangyu Zhu, Erqun Song and Yang Song

    Citation: Particle and Fibre Toxicology 2020 17:46

    Content type: Research

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  15. Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the par...

    Authors: Falko Frenzel, Laura König-Mattern, Valerie Stock, Linn Voss, Maxi B. Paul, Holger Sieg, Albert Braeuning, Andreas Voigt and Linda Böhmert

    Citation: Particle and Fibre Toxicology 2020 17:45

    Content type: Short report

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  16. Accurate knowledge of cell−/tissue-delivered dose plays a pivotal role in inhalation toxicology studies, since it is the key parameter for hazard assessment and translation of in vitro to in vivo dose-response...

    Authors: Yaobo Ding, Patrick Weindl, Anke-Gabriele Lenz, Paula Mayer, Tobias Krebs and Otmar Schmid

    Citation: Particle and Fibre Toxicology 2020 17:44

    Content type: Methodology

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  17. The quantification of nanomaterials accumulated in various organs is crucial in studying their toxicity and toxicokinetics. However, some types of nanomaterials, including carbon nanomaterials (CNMs), are diff...

    Authors: Dong-Keun Lee, Soyeon Jeon, Jiyoung Jeong, Kyung Seuk Song and Wan-Seob Cho

    Citation: Particle and Fibre Toxicology 2020 17:43

    Content type: Research

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  18. The toxicity of released metallic particles generated in metal-on-metal (MoM) total hip arthroplasty (THA) using cobalt chromium (CoCr) has raised concerns regarding their safety amongst both surgeons and the ...

    Authors: Jing Xu, Junyao Yang, Jian Chen, Xiaoli Zhang, Yuanhao Wu, Alister Hart, Agata Nyga and Julia C. Shelton

    Citation: Particle and Fibre Toxicology 2020 17:42

    Content type: Research

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  19. Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress i...

    Authors: Yu-Chen Chen, Tzu-Yi Chuang, Chen-Wei Liu, Chi-Wei Liu, Tzu-Lin Lee, Tsai-Chun Lai and Yuh-Lien Chen

    Citation: Particle and Fibre Toxicology 2020 17:41

    Content type: Research

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  20. Engineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological effects of end-of-lifecycle recycling and disposal of virgin and nano-...

    Authors: Jayme P. Coyle, Raymond C. Derk, Tiffany G. Kornberg, Dilpreet Singh, Jake Jensen, Sherri Friend, Robert Mercer, Todd A. Stueckle, Philip Demokritou, Yon Rojanasakul and Liying W. Rojanasakul

    Citation: Particle and Fibre Toxicology 2020 17:40

    Content type: Research

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  21. Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and i...

    Authors: Rongrong Wu, Johan Högberg, Mikael Adner, Patricia Ramos-Ramírez, Ulla Stenius and Huiyuan Zheng

    Citation: Particle and Fibre Toxicology 2020 17:39

    Content type: Research

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  22. Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to at...

    Authors: Katja Maria Bendtsen, Louise Gren, Vilhelm Berg Malmborg, Pravesh Chandra Shukla, Martin Tunér, Yona J. Essig, Annette M. Krais, Per Axel Clausen, Trine Berthing, Katrin Loeschner, Nicklas Raun Jacobsen, Henrik Wolff, Joakim Pagels and Ulla Birgitte Vogel

    Citation: Particle and Fibre Toxicology 2020 17:38

    Content type: Research

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  23. Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is known to significantly con...

    Authors: Yu-Wen Chen, Mei-Zi Huang, Chyi-Liang Chen, Chieh-Ying Kuo, Chia-Yu Yang, Chuan Chiang-Ni, Yi-Ywan M. Chen, Chia-Ming Hsieh, Hui-Yu Wu, Ming-Ling Kuo, Cheng-Hsun Chiu and Chih-Ho Lai

    Citation: Particle and Fibre Toxicology 2020 17:37

    Content type: Research

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  24. Exposure to air pollution has been associated with adverse effects on human health, and ultimately increased morbidity and mortality. This is predominantly due to hazardous effects on the cardiovascular system...

    Authors: Siri A. N. Holme, Torben Sigsgaard, Jørn A. Holme and Gitte Juel Holst

    Citation: Particle and Fibre Toxicology 2020 17:36

    Content type: Review

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  25. Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have b...

    Authors: Irini M. Dijkhoff, Barbara Drasler, Bedia Begum Karakocak, Alke Petri-Fink, Giuseppe Valacchi, Marc Eeman and Barbara Rothen-Rutishauser

    Citation: Particle and Fibre Toxicology 2020 17:35

    Content type: Review

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  26. Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety r...

    Authors: Min Beom Heo, Minjeong Kwak, Kyu Sup An, Hye Jin Kim, Hyeon Yeol Ryu, So Min Lee, Kyung Seuk Song, In Young Kim, Ji-Hwan Kwon and Tae Geol Lee

    Citation: Particle and Fibre Toxicology 2020 17:34

    Content type: Research

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  27. In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make seve...

    Authors: Kevin E. Driscoll, Paul A. Borm, Ishrat Chaudhuri, Len Levy, Mei Yong, David Warheit, Robert McCunney and Günter Oberdörster

    Citation: Particle and Fibre Toxicology 2020 17:33

    Content type: Letter to the Editor

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  28. In response to the Letter to the Editor by Kevin Driscoll et al., we certainly agree that particle clearance halftimes are increased with increasing lung burden in rats, hamsters and mice, whereas complete inh...

    Authors: Anne T. Saber, Sarah S. Poulsen, Niels Hadrup, Nicklas R. Jacobsen and Ulla Vogel

    Citation: Particle and Fibre Toxicology 2020 17:32

    Content type: Letter to the Editor

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  29. Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life. Understa...

    Authors: Battuja Batbajar Dugershaw, Leonie Aengenheister, Signe Schmidt Kjølner Hansen, Karin Sørig Hougaard and Tina Buerki-Thurnherr

    Citation: Particle and Fibre Toxicology 2020 17:31

    Content type: Review

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  30. Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues and tiny vascular structures. However, the bios...

    Authors: Tianshu Wu, Xue Liang, Xi Liu, Yimeng Li, Yutong Wang, Lu Kong and Meng Tang

    Citation: Particle and Fibre Toxicology 2020 17:30

    Content type: Research

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  31. Particle matter (PM) has been associated with increased morbidity and mortality rates across the world. This study was designed to test the hypotheses that pyrotechnic firework displays introduce significant a...

    Authors: Christina Hickey, Christopher Gordon, Karen Galdanes, Martin Blaustein, Lori Horton, Steven Chillrud, James Ross, Lital Yinon, Lung Chi Chen and Terry Gordon

    Citation: Particle and Fibre Toxicology 2020 17:28

    Content type: Research

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  32. Commercial uranium mining on the Navajo Nation has subjected communities on tribal lands in the Southwestern United States to exposures from residual environmental contamination. Vascular health effects from t...

    Authors: Bethany Sanchez, Xixi Zhou, Amy S. Gardiner, Guy Herbert, Selita Lucas, Masako Morishita, James G. Wagner, Ryan Lewandowski, Jack R. Harkema, Chris Shuey, Matthew J. Campen and Katherine E. Zychowski

    Citation: Particle and Fibre Toxicology 2020 17:29

    Content type: Research

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  33. Wood combustion emissions have been studied previously either by in vitro or in vivo models using collected particles, yet most studies have neglected gaseous compounds. Furthermore, a more accurate and holist...

    Authors: Tuukka Ihantola, Sebastiano Di Bucchianico, Mikko Happo, Mika Ihalainen, Oskari Uski, Stefanie Bauer, Kari Kuuspalo, Olli Sippula, Jarkko Tissari, Sebastian Oeder, Anni Hartikainen, Teemu J. Rönkkö, Maria-Viola Martikainen, Kati Huttunen, Petra Vartiainen, Heikki Suhonen…

    Citation: Particle and Fibre Toxicology 2020 17:27

    Content type: Research

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  34. Food-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets. Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to ...

    Authors: Christine Coméra, Christel Cartier, Eric Gaultier, Olivier Catrice, Quentin Panouille, Sarah El Hamdi, Kristof Tirez, Inge Nelissen, Vassilia Théodorou and Eric Houdeau

    Citation: Particle and Fibre Toxicology 2020 17:26

    Content type: Research

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  35. Epidemiologic studies have suggested that elevated concentrations of particulate matter (PM) are strongly associated with an increased risk of developing cardiovascular diseases, including arrhythmia. However,...

    Authors: Sujin Ju, Leejin Lim, Han-Yi Jiao, Seok Choi, Jae Yeoul Jun, Young-Jae Ki, Dong-Hyun Choi, Ji yi Lee and Heesang Song

    Citation: Particle and Fibre Toxicology 2020 17:25

    Content type: Research

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  36. Given the global abundance and environmental persistence, exposure of humans and (aquatic) animals to micro- and nanoplastics is unavoidable. Current evidence indicates that micro- and nanoplastics can be take...

    Authors: Minne Prüst, Jonelle Meijer and Remco H. S. Westerink

    Citation: Particle and Fibre Toxicology 2020 17:24

    Content type: Review

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  37. Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy...

    Authors: Mingxiang Wang, Jin Li, Shunni Dong, Xiaobo Cai, Aili Simaiti, Xin Yang, Xinqiang Zhu, Jianhong Luo, Lin-Hua Jiang, Binyang Du, Peilin Yu and Wei Yang

    Citation: Particle and Fibre Toxicology 2020 17:23

    Content type: Research

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  38. Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanis...

    Authors: Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiaowen Zeng, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng…

    Citation: Particle and Fibre Toxicology 2020 17:22

    Content type: Research

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  39. There is a steadily increasing quantity of silver nanoparticles (AgNP) produced for numerous industrial, medicinal and private purposes, leading to an increased risk of inhalation exposure for both professiona...

    Authors: Wolfgang G. Kreyling, Uwe Holzwarth, Stephanie Hirn, Carsten Schleh, Alexander Wenk, Martin Schäffler, Nadine Haberl and Neil Gibson

    Citation: Particle and Fibre Toxicology 2020 17:21

    Content type: Research

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  40. Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in...

    Authors: Erika Sato, Sandra A. McDonald, Yuwei Fan, Shaina Peterson, Joseph D. Brain and John J. Godleski

    Citation: Particle and Fibre Toxicology 2020 17:20

    Content type: Research

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  41. In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to t...

    Authors: Bruno Lamas, Natalia Martins Breyner and Eric Houdeau

    Citation: Particle and Fibre Toxicology 2020 17:19

    Content type: Review

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  42. The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative s...

    Authors: Sweelin Chew, Riikka Lampinen, Liudmila Saveleva, Paula Korhonen, Nikita Mikhailov, Alexandra Grubman, Jose M. Polo, Trevor Wilson, Mika Komppula, Teemu Rönkkö, Cheng Gu, Alan Mackay-Sim, Tarja Malm, Anthony R. White, Pasi Jalava and Katja M. Kanninen

    Citation: Particle and Fibre Toxicology 2020 17:18

    Content type: Research

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  43. Emissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations. Although the new passenger car regulat...

    Authors: Henri Hakkarainen, Päivi Aakko-Saksa, Maija Sainio, Tuukka Ihantola, Teemu J. Rönkkö, Päivi Koponen, Topi Rönkkö and Pasi I. Jalava

    Citation: Particle and Fibre Toxicology 2020 17:17

    Content type: Research

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  44. Toxicity testing and regulation of advanced materials at the nanoscale, i.e. nanosafety, is challenged by the growing number of nanomaterials and their property variants requiring assessment for potential huma...

    Authors: Sabina Halappanavar, Sybille van den Brule, Penny Nymark, Laurent Gaté, Carole Seidel, Sarah Valentino, Vadim Zhernovkov, Pernille Høgh Danielsen, Andrea De Vizcaya, Henrik Wolff, Tobias Stöger, Andrey Boyadziev, Sarah Søs Poulsen, Jorid Birkelund Sørli and Ulla Vogel

    Citation: Particle and Fibre Toxicology 2020 17:16

    Content type: Review

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  45. Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been r...

    Authors: Omar Lozano, Christian Silva-Platas, Héctor Chapoy-Villanueva, Baruc E. Pérez, Jarmon G. Lees, Chrishan J. A. Ramachandra, Flavio F. Contreras-Torres, Anay Lázaro-Alfaro, Estefanía Luna-Figueroa, Judith Bernal-Ramírez, Aldemar Gordillo-Galeano, Alfredo Benitez, Yuriana Oropeza-Almazán, Elena C. Castillo, Poh Ling Koh, Derek J. Hausenloy…

    Citation: Particle and Fibre Toxicology 2020 17:15

    Content type: Research

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  46. Emerging evidence supports ambient fine particulate matter (PM2.5) exposure is associated with insulin resistance (IR) and hepatic lipid accumulation. In this study, we aimed to evaluate the sex-dependent vulnera...

    Authors: Ran Li, Qing Sun, Sin Man Lam, Rucheng Chen, Junyao Zhu, Weijia Gu, Lu Zhang, He Tian, Kezhong Zhang, Lung-Chi Chen, Qinghua Sun, Guanghou Shui and Cuiqing Liu

    Citation: Particle and Fibre Toxicology 2020 17:14

    Content type: Research

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  47. Silica nanoparticles (SiNPs) are among the most widely manufactured and used nanoparticles. Concerns about potential health effects of SiNPs have therefore risen. Using a 3D tri-culture model of the alveolar l...

    Authors: Tonje Skuland, Marit Låg, Arno C. Gutleb, Bendik C. Brinchmann, Tommaso Serchi, Johan Øvrevik, Jørn A. Holme and Magne Refsnes

    Citation: Particle and Fibre Toxicology 2020 17:13

    Content type: Research

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  48. The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms w...

    Authors: De-Ping Wang, Zhao-Jun Wang, Rong Zhao, Cai-Xia Lin, Qian-Yu Sun, Cai-Ping Yan, Xin Zhou and Ji-Min Cao

    Citation: Particle and Fibre Toxicology 2020 17:12

    Content type: Research

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  49. Silver nanoparticles (AgNPs) are used extensively in various consumer products because of their antimicrobial potential. This requires insight in their potential hazards and risks including adverse effects dur...

    Authors: Ashraf Abdelkhaliq, Meike van der Zande, Ruud J. B. Peters and Hans Bouwmeester

    Citation: Particle and Fibre Toxicology 2020 17:11

    Content type: Research

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