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  1. It has been well recognized that toxicity of fine ambient air particulate matter (PM2.5) may depend on its chemical constituents, including components such as soluble metals that may theoretically exert distincti...

    Authors: Xiaohua Xu, Xiaoquan Rao, Tse-Yao Wang, Silis Y Jiang, Zhekang Ying, Cuiqing Liu, Aixia Wang, Mianhua Zhong, Jeffrey A Deiuliis, Andrei Maiseyeu, Sanjay Rajagopalan, Morton Lippmann, Lung-Chi Chen and Qinghua Sun
    Citation: Particle and Fibre Toxicology 2012 9:40
  2. In this response, we discuss the major differences that clearly distinguish our results from those mentioned by Faust et al. In particular, the experiments have been conducted on nanoparticles of different nat...

    Authors: Matthieu Fisichella, Frédéric Bérenguer, Gérard Steinmetz, Mélanie Auffan, Jérôme Rose and Odette Prat
    Citation: Particle and Fibre Toxicology 2012 9:39
  3. The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure th...

    Authors: Rakhee N Urankar, Robert M Lust, Erin Mann, Pranita Katwa, Xiaojia Wang, Ramakrishna Podila, Susana C Hilderbrand, Benjamin S Harrison, Pengyu Chen, Pu Chun Ke, Apparao M Rao, Jared M Brown and Christopher J Wingard
    Citation: Particle and Fibre Toxicology 2012 9:38
  4. One of the major areas for increasing the use of renewable energy is in traffic fuels e.g. bio-based fuels in diesel engines especially in commuter traffic. Exhaust emissions from fossil diesel fuelled engines...

    Authors: Pasi I Jalava, Päivi Aakko-Saksa, Timo Murtonen, Mikko S Happo, Ari Markkanen, Pasi Yli-Pirilä, Pasi Hakulinen, Risto Hillamo, Jorma Mäki-Paakkanen, Raimo O Salonen, Jorma Jokiniemi and Maija-Riitta Hirvonen
    Citation: Particle and Fibre Toxicology 2012 9:37
  5. Inorganic particles, such as drug carriers or contrast agents, are often introduced into the vascular system. Many key components of the in vivo vascular environment include monocyte-endothelial cell interactions...

    Authors: Xin Liu, Yang Xue, Tingting Ding and Jiao Sun
    Citation: Particle and Fibre Toxicology 2012 9:36
  6. Exposure to particulate matter (PM) is a significant risk factor for increased cardiopulmonary morbidity and mortality. The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammat...

    Authors: Ting Wang, Lichun Wang, Liliana Moreno-Vinasco, Gabriel D Lang, Jessica H Siegler, Biji Mathew, Peter V Usatyuk, Jonathan M Samet, Alison S Geyh, Patrick N Breysse, Viswanathan Natarajan and Joe G N Garcia
    Citation: Particle and Fibre Toxicology 2012 9:35
  7. Frustrated phagocytosis has been stated as an important factor in the initiation of an inflammatory response after fibre exposure. The length of fibrous structures has been linked to the potential of fibres to...

    Authors: Anja Schinwald and Ken Donaldson
    Citation: Particle and Fibre Toxicology 2012 9:34
  8. Predominantly, studies of nanoparticle (NPs) toxicology in vitro are based upon the exposure of submerged cell cultures to particle suspensions. Such an approach however, does not reflect particle inhalation. As ...

    Authors: David O Raemy, Robert N Grass, Wendelin J Stark, Christoph M Schumacher, Martin JD Clift, Peter Gehr and Barbara Rothen-Rutishauser
    Citation: Particle and Fibre Toxicology 2012 9:33
  9. Respirable crystalline silica (silicon dioxide; SiO2, quartz) particles are known to induce chronic inflammation and lung disease upon long-term inhalation, whereas non-crystalline (amorphous) SiO2 particles in t...

    Authors: Wiggo J Sandberg, Marit Låg, Jørn A Holme, Bernd Friede, Maurizio Gualtieri, Marcin Kruszewski, Per E Schwarze, Tonje Skuland and Magne Refsnes
    Citation: Particle and Fibre Toxicology 2012 9:32
  10. Diesel exhaust particles (DEP) contribute substantially to ambient particulate matter (PM) air pollution in urban areas. Inhalation of PM has been associated with increased incidence of lung disease in suscept...

    Authors: Weidong Wu, David B Peden, Rob McConnell, Scott Fruin and David Diaz-Sanchez
    Citation: Particle and Fibre Toxicology 2012 9:31
  11. Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (...

    Authors: Jakob Löndahl, Erik Swietlicki, Jenny Rissler, Agneta Bengtsson, Christoffer Boman, Anders Blomberg and Thomas Sandström
    Citation: Particle and Fibre Toxicology 2012 9:30
  12. Mechanisms for cellular uptake of nanoparticles have important implications for nanoparticulate drug delivery and toxicity. We have explored the mechanism of uptake of amorphous silica nanoparticles of 14 nm d...

    Authors: Qingshan Mu, Nicole S Hondow, Łukasz Krzemiński, Andy P Brown, Lars JC Jeuken and Michael N Routledge
    Citation: Particle and Fibre Toxicology 2012 9:29
  13. Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanis...

    Authors: Ali Kermanizadeh, Birgit K Gaiser, Gary R Hutchison and Vicki Stone
    Citation: Particle and Fibre Toxicology 2012 9:28
  14. Exposure to ultrafine particles exerts diverse harmful effects including aggravation of pulmonary diseases like asthma. Recently we demonstrated in a mouse model for allergic airway inflammation that particle-...

    Authors: Ingrid Beck-Speier, Erwin Karg, Heidrun Behrendt, Tobias Stoeger and Francesca Alessandrini
    Citation: Particle and Fibre Toxicology 2012 9:27
  15. Data from environmental exposure to nanoparticles (NPs) suggest that chronic exposure may increase the incidence of lung, cardiovascular and neurodegenerative diseases. Impairment of cell function by intracell...

    Authors: Eleonore Fröhlich, Claudia Meindl, Eva Roblegg, Birgit Ebner, Markus Absenger and Thomas R Pieber
    Citation: Particle and Fibre Toxicology 2012 9:26
  16. Welding, a process that generates an aerosol containing gases and metal-rich particulates, induces adverse physiological effects including inflammation, immunosuppression and cardiovascular dysfunction. This s...

    Authors: Aaron Erdely, James M Antonini, Rebecca Salmen-Muniz, Angie Liston, Tracy Hulderman, Petia P Simeonova, Michael L Kashon, Shengqiao Li, Ja K Gu, Samuel Stone, Bean T Chen, David G Frazer and Patti C Zeidler-Erdely
    Citation: Particle and Fibre Toxicology 2012 9:25
  17. Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflam...

    Authors: Dai-Hua Tsai, Nadia Amyai, Pedro Marques-Vidal, Jia-Lin Wang, Michael Riediker, Vincent Mooser, Fred Paccaud, Gerard Waeber, Peter Vollenweider and Murielle Bochud
    Citation: Particle and Fibre Toxicology 2012 9:24
  18. The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxic...

    Authors: Christian Freese, Chiara Uboldi, Matthew I Gibson, Ronald E Unger, Babette B Weksler, Ignacio A Romero, Pierre-Olivier Couraud and C James Kirkpatrick
    Citation: Particle and Fibre Toxicology 2012 9:23
  19. Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are ...

    Authors: Andrea Adamcakova-Dodd, Larissa V Stebounova, Patrick T O’Shaughnessy, Jong Sung Kim, Vicki H Grassian and Peter S Thorne
    Citation: Particle and Fibre Toxicology 2012 9:22
  20. Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been pr...

    Authors: Thomas J Grahame and Richard B Schlesinger
    Citation: Particle and Fibre Toxicology 2012 9:21
  21. Particulate air pollution has been linked to an increased risk of cardiovascular disease and cancer. Animal studies have shown that inhalation of air particulates induces mutations in the male germline. Expand...

    Authors: Anne Mette Zenner Boisen, Thomas Shipley, Petra Jackson, Karin Sørig Hougaard, Håkan Wallin, Carole L Yauk and Ulla Vogel
    Citation: Particle and Fibre Toxicology 2012 9:19
  22. Titanium dioxide (TiO2) nanoparticles (NPs) are widely used due to their specific properties, like UV filters in sunscreen. In that particular case TiO2 NPs are surface modified to avoid photocatalytic effects. T...

    Authors: Matthieu Fisichella, Frederic Berenguer, Gerard Steinmetz, Melanie Auffan, Jerome Rose and Odette Prat
    Citation: Particle and Fibre Toxicology 2012 9:18
  23. Increasing concern has been expressed regarding the potential adverse health effects that may be associated with human exposure to inhaled multi-walled carbon nanotubes (MWCNTs). Thus it is imperative that an ...

    Authors: Michael Gasser, Peter Wick, Martin JD Clift, Fabian Blank, Liliane Diener, Bing Yan, Peter Gehr, Harald F Krug and Barbara Rothen-Rutishauser
    Citation: Particle and Fibre Toxicology 2012 9:17
  24. Single-walled carbon nanotubes (SWCNT) trigger pronounced inflammation and fibrosis in the lungs of mice following administration via pharyngeal aspiration or inhalation. Human exposure to SWCNT in an occupati...

    Authors: Linda Swedin, Romanico Arrighi, Britta Andersson-Willman, Ashley Murray, Yunying Chen, Mikael C I Karlsson, Susanna Kumlien Georén, Alexey V Tkach, Anna A Shvedova, Bengt Fadeel, Antonio Barragan and Annika Scheynius
    Citation: Particle and Fibre Toxicology 2012 9:16
  25. We determined the ability of a model nanoparticle (NP) (titanium dioxide, TiO2) to modulate sensitization induced by a known potent dermal sensitizer (dinitrochlorobenzene) using a variant of the local lymph node...

    Authors: Salik Hussain, Stijn Smulders, Vanessa De Vooght, Bert Ectors, Sonja Boland, Francelyne Marano, Kirsten L Van Landuyt, Benoit Nemery, Peter HM Hoet and Jeroen AJ Vanoirbeek
    Citation: Particle and Fibre Toxicology 2012 9:15
  26. Carbon nanotubes (CNTs) are engineered graphene cylinders with numerous applications in engineering, electronics and medicine. However, CNTs cause inflammation and fibrosis in the rodent lung, suggesting a pot...

    Authors: Jong Kwon Lee, Brian C Sayers, Kyung-Soo Chun, Huei-Chen Lao, Jeanette K Shipley-Phillips, James C Bonner and Robert Langenbach
    Citation: Particle and Fibre Toxicology 2012 9:14
  27. Particle toxicology arose in order to understand the mechanisms of adverse effects of 3 major particle types that had historically exerted the greatest toll of ill-health—quartz, coal and asbestos. By the midd...

    Authors: Ken Donaldson and Anthony Seaton
    Citation: Particle and Fibre Toxicology 2012 9:13
  28. There is growing evidence that particulate air pollution derived from wood stoves causes acute inflammation in the respiratory system, increases the incidence of asthma and other allergic diseases, and increas...

    Authors: Ingunn Skogstad Riddervold, Jakob Hjort Bønløkke, Anna-Carin Olin, Therese Koops Grønborg, Vivi Schlünssen, Kristin Skogstrand, David Hougaard, Andreas Massling and Torben Sigsgaard
    Citation: Particle and Fibre Toxicology 2012 9:12
  29. Polymer nanoparticles (PNP) are becoming increasingly important in nanomedicine and food-based applications. Size and surface characteristics are often considered to be important factors in the cellular intera...

    Authors: Sourav Bhattacharjee, Dmitry Ershov, Kleanthis Fytianos, Jasper van der Gucht, Gerrit M Alink, Ivonne M C M Rietjens, Antonius T M Marcelis and Han Zuilhof
    Citation: Particle and Fibre Toxicology 2012 9:11
  30. Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurri...

    Authors: Ashley R Murray, Elena R Kisin, Alexey V Tkach, Naveena Yanamala, Robert Mercer, Shih-Houng Young, Bengt Fadeel, Valerian E Kagan and Anna A Shvedova
    Citation: Particle and Fibre Toxicology 2012 9:10
  31. Inhalation of diesel exhaust impairs vascular function in man, by a mechanism that has yet to be fully established. We hypothesised that pulmonary exposure to diesel exhaust particles (DEP) would cause endothe...

    Authors: Sarah Robertson, Gillian A Gray, Rodger Duffin, Steven G McLean, Catherine A Shaw, Patrick WF Hadoke, David E Newby and Mark R Miller
    Citation: Particle and Fibre Toxicology 2012 9:9
  32. Carbon nanotubes (CNT) are high aspect ratio nanoparticles with diameters in the nanometre range but lengths extending up to hundreds of microns. The structural similarities between CNT and asbestos have raise...

    Authors: Fiona A Murphy, Anja Schinwald, Craig A Poland and Ken Donaldson
    Citation: Particle and Fibre Toxicology 2012 9:8
  33. Exposure to wood smoke is associated with respiratory symptoms, whereas knowledge on systemic effects is limited. We investigated effects on systemic inflammation, oxidative stress and microvascular function (...

    Authors: Lykke Forchhammer, Peter Møller, Ingunn Skogstad Riddervold, Jakob Bønløkke, Andreas Massling, Torben Sigsgaard and Steffen Loft
    Citation: Particle and Fibre Toxicology 2012 9:7
  34. Exposure to respirable crystalline silica particles, as opposed to amorphous silica, is associated with lung inflammation, pulmonary fibrosis (silicosis), and potentially with lung cancer. We used Affymetrix/G...

    Authors: Timothy N Perkins, Arti Shukla, Paul M Peeters, Jeremy L Steinbacher, Christopher C Landry, Sherrill A Lathrop, Chad Steele, Niki L Reynaert, Emiel FM Wouters and Brooke T Mossman
    Citation: Particle and Fibre Toxicology 2012 9:6
  35. Widespread occupational exposure to carbon black nanoparticles (CBNPs) raises concerns over their safety. CBNPs are genotoxic in vitro but less is known about their genotoxicity in various organs in vivo.

    Authors: Julie A Bourdon, Anne T Saber, Nicklas R Jacobsen, Keld A Jensen, Anne M Madsen, Jacob S Lamson, Håkan Wallin, Peter Møller, Steffen Loft, Carole L Yauk and Ulla B Vogel
    Citation: Particle and Fibre Toxicology 2012 9:5
  36. Little is known of how the toxicity of nanoparticles is affected by the incorporation in complex matrices. We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embe...

    Authors: Anne Thoustrup Saber, Nicklas Raun Jacobsen, Alicia Mortensen, Józef Szarek, Petra Jackson, Anne Mette Madsen, Keld Alstrup Jensen, Ismo K Koponen, Gunnar Brunborg, Kristine Bjerve Gützkow, Ulla Vogel and Håkan Wallin
    Citation: Particle and Fibre Toxicology 2012 9:4
  37. Due to the rising use of nanomaterials (NMs), there is concern that NMs induce undesirable biological effects because of their unique physicochemical properties. Recently, we reported that amorphous silica nan...

    Authors: Toshiro Hirai, Tomoaki Yoshikawa, Hiromi Nabeshi, Tokuyuki Yoshida, Saeko Tochigi, Ko-ichi Ichihashi, Miyuki Uji, Takanori Akase, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Norio Itoh, Shin-ichi Tsunoda, Yasuo Yoshioka and Yasuo Tsutsumi
    Citation: Particle and Fibre Toxicology 2012 9:3
  38. Histamine released from mast cells, through complex interactions involving the binding of IgE to FcεRI receptors and the subsequent intracellular Ca2+ signaling, can mediate many allergic/inflammatory responses. ...

    Authors: Eric Y Chen, Maria Garnica, Yung-Chen Wang, Alexander J Mintz, Chi-Shuo Chen and Wei-Chun Chin
    Citation: Particle and Fibre Toxicology 2012 9:2
  39. Recently, we used cell-free assays to demonstrate the toxic effects of complex mixtures of organic extracts from urban air particles (PM2.5) collected in four localities of the Czech Republic (Ostrava-Bartovic...

    Authors: Helena Líbalová, Kateřina Uhlířová, Jiří Kléma, Miroslav Machala, Radim J Šrám, Miroslav Ciganek and Jan Topinka
    Citation: Particle and Fibre Toxicology 2012 9:1
  40. In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (le...

    Authors: Linda C Stoehr, Edgar Gonzalez, Andreas Stampfl, Eudald Casals, Albert Duschl, Victor Puntes and Gertie J Oostingh
    Citation: Particle and Fibre Toxicology 2011 8:36
  41. Our previous studies demonstrated that tilmicosin-loaded hydrogenated castor oil solid lipid nanoparticles (Til-HCO-SLN) are a promising formulation for enhanced pharmacological activity and therapeutic effica...

    Authors: Shuyu Xie, Fenghua Wang, Yan Wang, Luyan Zhu, Zhao Dong, Xiaofang Wang, Xihe Li and WenZhong Zhou
    Citation: Particle and Fibre Toxicology 2011 8:33
  42. There is growing evidence that exposure to small size particulate matter increases the risk of developing cardiovascular disease.

    Authors: Lone Mikkelsen, Majid Sheykhzade, Keld A Jensen, Anne T Saber, Nicklas R Jacobsen, Ulla Vogel, Håkan Wallin, Steffen Loft and Peter Møller
    Citation: Particle and Fibre Toxicology 2011 8:32
  43. Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise mechanisms of particle uptake and generation of inflammatory mediators by alveolar macrophages (AM) are still poorly under...

    Authors: Agnes M Scherbart, Julia Langer, Alexey Bushmelev, Damiёn van Berlo, Petra Haberzettl, Frederik-Jan van Schooten, Annette M Schmidt, Christine R Rose, Roel PF Schins and Catrin Albrecht
    Citation: Particle and Fibre Toxicology 2011 8:31
  44. Obesity can be linked to disease risks such as diabetes and cardiovascular disorders, but recently, the adipose tissue (AT) macrophage also emerges as actively participating in inflammation and immune function...

    Authors: Alexander A Götz, Jan Rozman, Heiko G Rödel, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Martin Klingenspor and Tobias Stoeger
    Citation: Particle and Fibre Toxicology 2011 8:30
  45. Human exposure to nanoparticles (NPs) and environmental bacteria can occur simultaneously. NPs induce inflammatory responses and oxidative stress but may also have immune-suppressive effects, impairing macroph...

    Authors: Jong Sung Kim, Andrea Adamcakova-Dodd, Patrick T O'Shaughnessy, Vicki H Grassian and Peter S Thorne
    Citation: Particle and Fibre Toxicology 2011 8:29
  46. The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-in...

    Authors: Alexander A Götz, Antonio Vidal-Puig, Heiko G Rödel, Martin Hrabé de Angelis and Tobias Stoeger
    Citation: Particle and Fibre Toxicology 2011 8:28
  47. Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the path...

    Authors: Wan-Seob Cho, Rodger Duffin, Sarah EM Howie, Chris J Scotton, William AH Wallace, William MacNee, Mark Bradley, Ian L Megson and Ken Donaldson
    Citation: Particle and Fibre Toxicology 2011 8:27

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