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  1. Traffic emissions including diesel engine exhaust are associated with increased respiratory and cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular fun...

    Authors: Stefan Barath, Nicholas L Mills, Magnus Lundbäck, Håkan Törnqvist, Andrew J Lucking, Jeremy P Langrish, Stefan Söderberg, Christoffer Boman, Roger Westerholm, Jakob Löndahl, Ken Donaldson, Ian S Mudway, Thomas Sandström, David E Newby and Anders Blomberg
    Citation: Particle and Fibre Toxicology 2010 7:19
    Content type: Research Published on:

  2. Nowadays, effects of fine particulate matter (PM2.5) are well-documented and related to oxidative stress and pro-inflammatory response. Nevertheless, epidemiological studies show that PM2.5 exposure is correlated...

    Authors: Ioana Ferecatu, Marie-Caroline Borot, Camille Bossard, Melanie Leroux, Nicole Boggetto, Francelyne Marano, Armelle Baeza-Squiban and Karine Andreau
    Citation: Particle and Fibre Toxicology 2010 7:18
    Content type: Research Published on:

  3. Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structu...

    Authors: Sofian Metassan, Michael N Routledge, Andrew J Lucking, Shirley Uitte de Willige, Helen Philippou, Nicholas L Mills, David E Newby and Robert AS Ariëns
    Citation: Particle and Fibre Toxicology 2010 7:17
    Content type: Short report Published on:

  4. Engineered nanoparticles are smaller than 100 nm and designed to improve or achieve new physico-chemical properties. Consequently, also toxicological properties may change compared to the parent compound. We e...

    Authors: Karin S Hougaard, Petra Jackson, Keld A Jensen, Jens J Sloth, Katrin Löschner, Erik H Larsen, Renie K Birkedal, Anni Vibenholt, Anne-Mette Z Boisen, Håkan Wallin and Ulla Vogel
    Citation: Particle and Fibre Toxicology 2010 7:16
    Content type: Research Published on:

    The Erratum to this article has been published in Particle and Fibre Toxicology 2011 8:14

  5. In order to understand how nanoparticles (NPs <100 nm) interact with cellular systems, potentially causing adverse effects, it is important to be able to detect and localize them within cells. Due to the small...

    Authors: Christina Brandenberger, Martin JD Clift, Dimitri Vanhecke, Christian Mühlfeld, Vicki Stone, Peter Gehr and Barbara Rothen-Rutishauser
    Citation: Particle and Fibre Toxicology 2010 7:15
    Content type: Short report Published on:

  6. Exposure to fine airborne particles (PM2.5) has been shown to be responsible for cardiovascular and hematological effects, especially in older people with cardiovascular disease. Some epidemiological studies sugg...

    Authors: Alexandra Schneider, Lucas M Neas, Don W Graff, Margaret C Herbst, Wayne E Cascio, Mike T Schmitt, John B Buse, Annette Peters and Robert B Devlin
    Citation: Particle and Fibre Toxicology 2010 7:14
    Content type: Research Published on:

  7. In the initiation and progression of pulmonary inflammation, macrophages have classically been considered as a crucial cell type. However, evidence for the role of epithelial type II cells in pulmonary inflamm...

    Authors: Damien van Berlo, Ad M Knaapen, Frederik-Jan van Schooten, Roel PF Schins and Catrin Albrecht
    Citation: Particle and Fibre Toxicology 2010 7:13
    Content type: Research Published on:

  8. The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement o...

    Authors: Miriam E Gerlofs-Nijland, Damien van Berlo, Flemming R Cassee, Roel PF Schins, Kate Wang and Arezoo Campbell
    Citation: Particle and Fibre Toxicology 2010 7:12
    Content type: Research Published on:

  9. Clara cell protein (CC16), the main secretory product of bronchiolar Clara cells, plays an important protective role in the respiratory tract against oxidative stress and inflammation. The purpose of the study...

    Authors: Francesca Alessandrini, Ingrid Weichenmeier, Erik van Miert, Shinji Takenaka, Erwin Karg, Cornelia Blume, Martin Mempel, Holger Schulz, Alfred Bernard and Heidrun Behrendt
    Citation: Particle and Fibre Toxicology 2010 7:11
    Content type: Research Published on:

  10. Increasing environmental and occupational exposures to nanoparticles (NPs) warrant deeper insight into the toxicological mechanisms induced by these materials. The present study was designed to characterize th...

    Authors: Salik Hussain, Leen CJ Thomassen, Ioana Ferecatu, Marie-Caroline Borot, Karine Andreau, Johan A Martens, Jocelyne Fleury, Armelle Baeza-Squiban, Francelyne Marano and Sonja Boland
    Citation: Particle and Fibre Toxicology 2010 7:10
    Content type: Research Published on:

  11. Elevated levels of air pollution are associated with increased risk of lung cancer. Particulate matter (PM) contains transition metals that may potentiate neoplastic development through the induction of oxidat...

    Authors: Elizabeth A Rondini, Dianne M Walters and Alison K Bauer
    Citation: Particle and Fibre Toxicology 2010 7:9
    Content type: Research Published on:

  12. Silver nanoparticles have been used in numerous commercial products, including textiles, to prevent bacterial growth. Meanwhile, there is increasing concern that exposure to these nanoparticles may cause poten...

    Authors: Kornphimol Kulthong, Sujittra Srisung, Kanittha Boonpavanitchakul, Wiyong Kangwansupamonkon and Rawiwan Maniratanachote
    Citation: Particle and Fibre Toxicology 2010 7:8
    Content type: Research Published on:

  13. Epidemiological studies have suggested that suspended particulate matter (SPM) causes detrimental health effects such as respiratory and cardiovascular diseases, and that diesel exhaust particles from automobi...

    Authors: Tomoharu Suzuki, Shigeru Oshio, Mari Iwata, Hisayo Saburi, Takashi Odagiri, Tadashi Udagawa, Isamu Sugawara, Masakazu Umezawa and Ken Takeda
    Citation: Particle and Fibre Toxicology 2010 7:7
    Content type: Research Published on:

  14. Epidemiological evidence supports the association between exposure to ambient particulate matter (PM) and cardiovascular diseases. Chronic exposure to ultrafine particles (UFP; Dp <100 nm) is reported to promote ...

    Authors: Rongsong Li, Zhi Ning, Rohit Majumdar, Jeffery Cui, Wakako Takabe, Nelson Jen, Constantinos Sioutas and Tzung Hsiai
    Citation: Particle and Fibre Toxicology 2010 7:6
    Content type: Research Published on:

  15. The unique hazard posed to the pleural mesothelium by asbestos has engendered concern in potential for a similar risk from high aspect ratio nanoparticles (HARN) such as carbon nanotubes. In the course of stud...

    Authors: Ken Donaldson, Fiona A Murphy, Rodger Duffin and Craig A Poland
    Citation: Particle and Fibre Toxicology 2010 7:5
    Content type: Review Published on:

  16. We used fullerenes, whose dispersion at the nano-level was stabilized by grinding in nitrogen gas in an agitation mill, to conduct an intratracheal instillation study and an inhalation exposure study. Fulleren...

    Authors: Yasuo Morimoto, Masami Hirohashi, Akira Ogami, Takako Oyabu, Toshihiko Myojo, Ken-ichiro Nishi, Chikara Kadoya, Motoi Todoroki, Makoto Yamamoto, Masahiro Murakami, Manabu Shimada, Wei-Ning Wang, Kazuhiro Yamamoto, Katsuhide Fujita, Shigehisa Endoh, Kunio Uchida…
    Citation: Particle and Fibre Toxicology 2010 7:4
    Content type: Research Published on:

  17. Nanotechnology has brought a variety of new possibilities into biological discovery and clinical practice. In particular, nano-scaled carriers have revolutionalized drug delivery, allowing for therapeutic agen...

    Authors: Sonu Bhaskar, Furong Tian, Tobias Stoeger, Wolfgang Kreyling, Jesús M de la Fuente, Valeria Grazú, Paul Borm, Giovani Estrada, Vasilis Ntziachristos and Daniel Razansky
    Citation: Particle and Fibre Toxicology 2010 7:3
    Content type: Review Published on:

  18. Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help t...

    Authors: Marianne Geiser and Wolfgang G Kreyling
    Citation: Particle and Fibre Toxicology 2010 7:2
    Content type: Review Published on:

  19. Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the ...

    Authors: Xifei Yang, Jianjun Liu, Haowei He, Li Zhou, Chunmei Gong, Xiaomei Wang, Lingqing Yang, Jianhui Yuan, Haiyan Huang, Lianhua He, Bing Zhang and Zhixiong Zhuang
    Citation: Particle and Fibre Toxicology 2010 7:1
    Content type: Research Published on:

  20. Titanium dioxide (TiO2) nanomaterials have considerable beneficial uses as photocatalysts and solar cells. It has been established for many years that pigment-grade TiO2 (200 nm sphere) is relatively inert when i...

    Authors: Raymond F Hamilton Jr, Nianqiang Wu, Dale Porter, Mary Buford, Michael Wolfarth and Andrij Holian
    Citation: Particle and Fibre Toxicology 2009 6:35
    Content type: Research Published on:

  21. Ambient particulate matter (PM)-associated metals have been shown to play an important role in cardiopulmonary health outcomes. To study the modulation of PM-induced inflammation by leached off metals, we inve...

    Authors: Ingrid Beck-Speier, Wolfgang G Kreyling, Konrad L Maier, Niru Dayal, Mette C Schladweiler, Paula Mayer, Manuela Semmler-Behnke and Urmila P Kodavanti
    Citation: Particle and Fibre Toxicology 2009 6:34
    Content type: Research Published on:

  22. This review focuses on outlining the toxicity of titanium dioxide (TiO2) particulates in vitro and in vivo, in order to understand their ability to detrimentally impact on human health. Evaluating the hazards ass...

    Authors: Helinor J Johnston, Gary R Hutchison, Frans M Christensen, Sheona Peters, Steve Hankin and Vicki Stone
    Citation: Particle and Fibre Toxicology 2009 6:33
    Content type: Review Published on:

  23. Engineered nanoparticles are becoming increasingly ubiquitous and their toxicological effects on human health, as well as on the ecosystem, have become a concern. Since initial contact with nanoparticles occur...

    Authors: Anke Gabriele Lenz, Erwin Karg, Bernd Lentner, Vlad Dittrich, Christina Brandenberger, Barbara Rothen-Rutishauser, Holger Schulz, George A Ferron and Otmar Schmid
    Citation: Particle and Fibre Toxicology 2009 6:32
    Content type: Research Published on:

  24. Carbonaceous nanoparticles possess an emerging source of human exposure due to the massive release of combustion products and the ongoing revolution in nanotechnology. Pulmonary inflammation caused by deposite...

    Authors: Koustav Ganguly, Swapna Upadhyay, Martin Irmler, Shinji Takenaka, Katrin Pukelsheim, Johannes Beckers, Eckard Hamelmann, Holger Schulz and Tobias Stoeger
    Citation: Particle and Fibre Toxicology 2009 6:31
    Content type: Research Published on:

  25. Fine particulate matter originating from traffic correlates with increased morbidity and mortality. An important source of traffic particles is brake wear of cars which contributes up to 20% of the total traff...

    Authors: Michael Gasser, Michael Riediker, Loretta Mueller, Alain Perrenoud, Fabian Blank, Peter Gehr and Barbara Rothen-Rutishauser
    Citation: Particle and Fibre Toxicology 2009 6:30
    Content type: Research Published on:

  26. Residential wood combustion is now recognized as a major particle source in many developed countries, and the number of studies investigating the negative health effects associated with wood smoke exposure is ...

    Authors: Anette Kocbach Bølling, Joakim Pagels, Karl Espen Yttri, Lars Barregard, Gerd Sallsten, Per E Schwarze and Christoffer Boman
    Citation: Particle and Fibre Toxicology 2009 6:29
    Content type: Review Published on:

  27. Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not merely quantitative...

    Authors: Paul Borm and Vince Castranova
    Citation: Particle and Fibre Toxicology 2009 6:28
    Content type: Editorial Published on:

  28. Cytochrome P450 monoxygenases play an important role in the defence against inhaled toxic compounds and in metabolizing a wide range of xenobiotics and environmental contaminants. In ambient aerosol the ultrafin...

    Authors: Christiane Eder, Marion Frankenberger, Franz Stanzel, Albrecht Seidel, Karl-Werner Schramm, Loems Ziegler-Heitbrock and Thomas PJ Hofer
    Citation: Particle and Fibre Toxicology 2009 6:27
    Content type: Research Published on:

  29. Using an in vitro triple cell co-culture model consisting of human epithelial cells (16HBE14o-), monocyte-derived macrophages and dendritic cells, it was recently demonstrated that macrophages and dendritic cells...

    Authors: Andrea D Lehmann, Fabian Blank, Oliver Baum, Peter Gehr and Barbara M Rothen-Rutishauser
    Citation: Particle and Fibre Toxicology 2009 6:26
    Content type: Research Published on:

  30. Growing evidence indicates that ambient air pollution is associated with exacerbation of chronic diseases like chronic pulmonary disease. A prospective panel study was conducted to investigate short-term chang...

    Authors: Katharina Hildebrandt, Regina Rückerl, Wolfgang Koenig, Alexandra Schneider, Mike Pitz, Joachim Heinrich, Victor Marder, Mark Frampton, Günter Oberdörster, H Erich Wichmann and Annette Peters
    Citation: Particle and Fibre Toxicology 2009 6:25
    Content type: Research Published on:

  32. Recently, manufactured nano/microparticles such as fullerenes (C60), carbon black (CB) and ceramic fiber are being widely used because of their desirable properties in industrial, medical and cosmetic fields. How...

    Authors: Yukari Totsuka, Takashi Higuchi, Toshio Imai, Akiyoshi Nishikawa, Takehiko Nohmi, Tatsuya Kato, Shuich Masuda, Naohide Kinae, Kyoko Hiyoshi, Sayaka Ogo, Masanobu Kawanishi, Takashi Yagi, Takamichi Ichinose, Nobutaka Fukumori, Masatoshi Watanabe, Takashi Sugimura…
    Citation: Particle and Fibre Toxicology 2009 6:23
    Content type: Research Published on:

  33. Viral infections and exposure to oxidant air pollutants are two of the most important inducers of asthma exacerbation. Our previous studies have demonstrated that exposure to diesel exhaust increases the susce...

    Authors: Ilona Jaspers, Patricia A Sheridan, Wenli Zhang, Luisa E Brighton, Kelly D Chason, Xiaoyang Hua and Stephen L Tilley
    Citation: Particle and Fibre Toxicology 2009 6:22
    Content type: Research Published on:

  34. Many polycyclic aromatic hydrocarbons (PAHs) can cause DNA adducts and initiate carcinogenesis. Mixed exposures to coal dust (CD) and PAHs are common in occupational settings. In the CD and PAH-exposed lung, C...

    Authors: Mohamed M Ghanem, Lori A Battelli, Brandon F Law, Vincent Castranova, Michael L Kashon, Joginder Nath and Ann F Hubbs
    Citation: Particle and Fibre Toxicology 2009 6:21
    Content type: Research Published on:

  35. Nanotechnology is developing rapidly throughout the world and the production of novel man-made nanoparticles is increasing, it is therefore of concern that nanomaterials have the potential to affect human heal...

    Authors: Midori Shimizu, Hitoshi Tainaka, Taro Oba, Keisuke Mizuo, Masakazu Umezawa and Ken Takeda
    Citation: Particle and Fibre Toxicology 2009 6:20
    Content type: Research Published on:

  36. Exposure to fine ambient particulate matter (PM) has consistently been associated with increased morbidity and mortality. The relationship between exposure to ultrafine particles (UFP) and health effects is le...

    Authors: Anne B Knol, Jeroen J de Hartog, Hanna Boogaard, Pauline Slottje, Jeroen P van der Sluijs, Erik Lebret, Flemming R Cassee, J Arjan Wardekker, Jon G Ayres, Paul J Borm, Bert Brunekreef, Kenneth Donaldson, Francesco Forastiere, Stephen T Holgate, Wolfgang G Kreyling, Benoit Nemery…
    Citation: Particle and Fibre Toxicology 2009 6:19
    Content type: Research Published on:

  37. During the last years engineered nanoparticles (NPs) have been extensively used in different technologies and consequently many questions have arisen about the risk and the impact on human health following exp...

    Authors: Chiara Uboldi, Daniele Bonacchi, Giada Lorenzi, M Iris Hermanns, Christine Pohl, Giovanni Baldi, Ronald E Unger and C James Kirkpatrick
    Citation: Particle and Fibre Toxicology 2009 6:18
    Content type: Research Published on:

  38. Titanium dioxide (TiO2), also known as titanium (IV) oxide or anatase, is the naturally occurring oxide of titanium. It is also one of the most commercially used form. To date, no parameter has been set for the a...

    Authors: Kunal Bhattacharya, Maria Davoren, Jens Boertz, Roel PF Schins, Eik Hoffmann and Elke Dopp
    Citation: Particle and Fibre Toxicology 2009 6:17
    Content type: Research Published on:

  40. Nanoparticles are characterized by having a high surface area per mass. Particulate surface area has been reported to play an important role in determining the biological activity of nanoparticles. However, re...

    Authors: Tina M Sager and Vincent Castranova
    Citation: Particle and Fibre Toxicology 2009 6:15
    Content type: Research Published on:

  41. A critical issue with nanomaterials is the clear understanding of their potential toxicity. We evaluated the toxic effect of 24 nanoparticles of similar equivalent spherical diameter and various elemental comp...

    Authors: Sophie Lanone, Françoise Rogerieux, Jorina Geys, Aurélie Dupont, Emmanuelle Maillot-Marechal, Jorge Boczkowski, Ghislaine Lacroix and Peter Hoet
    Citation: Particle and Fibre Toxicology 2009 6:14
    Content type: Research Published on:

  42. In vitro studies with particles are a major staple of particle toxicology, generally used to investigate mechanisms and better understand the molecular events underlying cellular effects. However, there is ethic...

    Authors: Ken Donaldson, Paul JA Borm, Vincent Castranova and Mary Gulumian
    Citation: Particle and Fibre Toxicology 2009 6:13
    Content type: Review Published on:

  43. Epidemiologic and animal studies have shown that particulate air pollution is associated with increased risk of lung and cardiovascular diseases. Although the exact mechanisms by which particles induce cardiov...

    Authors: Anne T Saber, Sabina Halappanavar, Janne K Folkmann, Jette Bornholdt, Anne Mette Z Z Boisen, Peter Møller, Andrew Williams, Carole Yauk, Ulla Vogel, Steffen Loft and Håkan Wallin
    Citation: Particle and Fibre Toxicology 2009 6:12
    Content type: Research Published on:

  44. Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that co...

    Authors: Shrilatha Balakrishna, Slawo Lomnicki, Kevin M McAvey, Richard B Cole, Barry Dellinger and Stephania A Cormier
    Citation: Particle and Fibre Toxicology 2009 6:11
    Content type: Research Published on:

  45. The contribution of air particles in human cardio-respiratory diseases has been enlightened by several epidemiological studies. However the respective involvement of coarse, fine and ultrafine particles in hea...

    Authors: Kiran Ramgolam, Olivier Favez, Hélène Cachier, Annie Gaudichet, Francelyne Marano, Laurent Martinon and Armelle Baeza-Squiban
    Citation: Particle and Fibre Toxicology 2009 6:10
    Content type: Research Published on:

  46. The exposure to pollutants such as diesel exhaust particles (DEP) is associated with an increased incidence of respiratory diseases. However, the mechanisms by which DEP have an effect on human health are not ...

    Authors: Solenne Taront, Audrey Dieudonné, Simon Blanchard, Pascale Jeannin, Philippe Lassalle, Yves Delneste and Philippe Gosset
    Citation: Particle and Fibre Toxicology 2009 6:9
    Content type: Research Published on:

  47. Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and my...

    Authors: Jeremy P Langrish, Nicholas L Mills, Julian KK Chan, Daan LAC Leseman, Robert J Aitken, Paul HB Fokkens, Flemming R Cassee, Jing Li, Ken Donaldson, David E Newby and Lixin Jiang
    Citation: Particle and Fibre Toxicology 2009 6:8
    Content type: Research Published on:

  48. Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial ...

    Authors: Magnus Lundbäck, Nicholas L Mills, Andrew Lucking, Stefan Barath, Ken Donaldson, David E Newby, Thomas Sandström and Anders Blomberg
    Citation: Particle and Fibre Toxicology 2009 6:7
    Content type: Research Published on:

  49. Individuals with chronic lung disease are at increased risk of adverse health effects from airborne particulate matter. Characterization of underlying pollutant-phenotype interactions may require comprehensive...

    Authors: Errol M Thomson, Andrew Williams, Carole L Yauk and Renaud Vincent
    Citation: Particle and Fibre Toxicology 2009 6:6
    Content type: Research Published on:

  50. Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to ...

    Authors: Lise K Vesterdal, Janne K Folkmann, Nicklas R Jacobsen, Majid Sheykhzade, Håkan Wallin, Steffen Loft and Peter Møller
    Citation: Particle and Fibre Toxicology 2009 6:5
    Content type: Research Published on:

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