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  1. Montmorillonite (Mt) and its derivatives are now widely used in industrial and biomedical fields. Therefore, safety assessments of these materials are critical to protect human health after exposure; however, ...

    Authors: Jia Liu, Shubin Yang, Laien Zhao, Feng Jiang, Jianchao Sun, Shengjun Peng, Ruikang Zhao, Yanmei Huang, Xiaoxuan Fu, Rongrui Luo, Yu Jiang, Zelin Li, Nan Wang, Tengzheng Fang and Zhuhong Zhang
    Citation: Particle and Fibre Toxicology 2023 20:8
  2. Air pollution has emerged as an unexpected risk factor for diabetes. However, the mechanism behind remains ill-defined. So far, the lung has been considered as the main target organ of air pollution. In contra...

    Authors: Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Lena Keller, Zora Baumann, Neena Parayil, Marc Stawiski, Leila Rachid, Thomas Dervos, Sandra Mitrovic, Daniel T. Meier and Claudia Cavelti-Weder
    Citation: Particle and Fibre Toxicology 2023 20:7
  3. A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported that microglial activation in ischemic stroke plays an important ro...

    Authors: Miki Tanaka, Tomoaki Okuda, Kouichi Itoh, Nami Ishihara, Ami Oguro, Yoshiaki Fujii-Kuriyama, Yu Nabetani, Megumi Yamamoto, Christoph F. A. Vogel and Yasuhiro Ishihara
    Citation: Particle and Fibre Toxicology 2023 20:6
  4. Toxicity assessment for regulatory purposes is starting to move away from traditional in vivo methods and towards new approach methodologies (NAM) such as high-throughput in vitro models and computational tool...

    Authors: Polly McLean, William Mueller, Ilse Gosens, Flemming R. Cassee, Barbara Rothen-Rutishauser, Matthew Boyles and Lang Tran
    Citation: Particle and Fibre Toxicology 2023 20:5
  5. Acute phase response (APR) is characterized by a change in concentration of different proteins, including C-reactive protein and serum amyloid A (SAA) that can be linked to both exposure to metal oxide nanomat...

    Authors: Claudia Torero Gutierrez, Charis Loizides, Iosif Hafez, Anders Brostrøm, Henrik Wolff, Józef Szarek, Trine Berthing, Alicja Mortensen, Keld Alstrup Jensen, Martin Roursgaard, Anne Thoustrup Saber, Peter Møller, George Biskos and Ulla Vogel
    Citation: Particle and Fibre Toxicology 2023 20:4
  6. Nano- and microplastic particles (NMP) are strong environmental contaminants affecting marine ecosystems and human health. The negligible use of biodegradable plastics and the lack of knowledge about plastic u...

    Authors: Anke Schmidt, Walison Augusto da Silva Brito, Debora Singer, Melissa Mühl, Julia Berner, Fariba Saadati, Christina Wolff, Lea Miebach, Kristian Wende and Sander Bekeschus
    Citation: Particle and Fibre Toxicology 2023 20:3
  7. Polypropylene (PP) is used in various products such as disposable containers, spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly comprise PP, and the disposal of such masks ...

    Authors: Jong-Hwan Woo, Hyeon Jin Seo, Jun-Young Lee, Iljung Lee, Kisoo Jeon, Bumseok Kim and Kyuhong Lee
    Citation: Particle and Fibre Toxicology 2023 20:2
  8. Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s)...

    Authors: Ozge Kose, Paride Mantecca, Anna Costa and Marie Carrière
    Citation: Particle and Fibre Toxicology 2023 20:1
  9. Many studies have shown that occupational exposure to indium and its compounds could induce lung disease. Although animal toxicological studies and human epidemiological studies suggest indium exposure may cau...

    Authors: Nan Liu, Yi Guan, Yan Yu, Gai Li, Ling Xue, Weikang Li, Xiaoyu Qu, Ning Li and Sanqiao Yao
    Citation: Particle and Fibre Toxicology 2022 19:69
  10. Nanomaterials can exist in different nanoforms (NFs). Their grouping may be supported by the formulation of hypotheses which can be interrogated via integrated approaches to testing and assessment (IATA). IATA...

    Authors: Luisana Di Cristo, Victor C. Ude, Georgia Tsiliki, Giuseppina Tatulli, Alessio Romaldini, Fiona Murphy, Wendel Wohlleben, Agnes G. Oomen, Pier P. Pompa, Josje Arts, Vicki Stone and Stefania Sabella
    Citation: Particle and Fibre Toxicology 2022 19:68
  11. The impacts of air pollution on public health have become a great concern worldwide. Ambient particulate matter (PM) is a major air pollution that comprises a heterogeneous mixture of different particle sizes ...

    Authors: Tianyu Li, Yang Yu, Zhiwei Sun and Junchao Duan
    Citation: Particle and Fibre Toxicology 2022 19:67
  12. Traffic-related air pollution (TRAP) exposure causes adverse effects on wellbeing and quality of life, which can be studied non-invasively using self-reported symptoms. However, little is known about the effec...

    Authors: Juma Orach, Christopher Francis Rider, Agnes Che Yan Yuen and Christopher Carlsten
    Citation: Particle and Fibre Toxicology 2022 19:66
  13. Exposure to particulate matter air pollution is associated with an increased risk of cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are no...

    Authors: Teng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu and Tong Zhu
    Citation: Particle and Fibre Toxicology 2022 19:65
  14. Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary dise...

    Authors: Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding and Zhongbing Lu
    Citation: Particle and Fibre Toxicology 2022 19:64
  15. The toxicokinetic behaviour of nanostructured particles following pulmonary or oral deposition is of great scientific interest. In this toxicokinetic study, following the general principles of OECD TG 417, the...

    Authors: Otto Creutzenberg, Volker Hammann, Stefanie Wolf, Jürgen Daul, Yufanyi Ngiewih, Ishrat Chaudhuri and Len Levy
    Citation: Particle and Fibre Toxicology 2022 19:63
  16. A key aspect of any new material safety assessment is the evaluation of their in vivo genotoxicity. Graphene oxide (GO) has been studied for many promising applications, but there are remaining concerns about ...

    Authors: Luis Augusto Visani de Luna, Thomas Loret, Alexander Fordham, Atta Arshad, Matthew Drummond, Abbie Dodd, Neus Lozano, Kostas Kostarelos and Cyrill Bussy
    Citation: Particle and Fibre Toxicology 2022 19:62
  17. Exposure to air pollutants is one of the major environmental health risks faced by populations globally. Information about inhaled particle deposition dose is crucial in establishing the dose–response function...

    Authors: Leizel Madueño, Simonas Kecorius, Jakob Löndahl, Jürgen Schnelle-Kreis, Alfred Wiedensohler and Mira Pöhlker
    Citation: Particle and Fibre Toxicology 2022 19:61
  18. Microplastics (MPs) and nanoplastics (NPs) formed from decomposed plastic are increasing environmental threats. Although MPs and NPs exposed through various routes enter the systemic circulation, the potential...

    Authors: Eun-Hye Kim, Sungbin Choi, Donghyun Kim, Han Jin Park, Yiying Bian, Sang Ho Choi, Han Young Chung and Ok-Nam Bae
    Citation: Particle and Fibre Toxicology 2022 19:60
  19. The number of publications in the field of nanogenotoxicology and the amount of genotoxicity data on nanomaterials (NMs) in several databases generated by European Union (EU) funded projects have increased dur...

    Authors: Kirsi M. Siivola, Michael J. Burgum, Blanca Suárez-Merino, Martin J. D. Clift, Shareen H. Doak and Julia Catalán
    Citation: Particle and Fibre Toxicology 2022 19:59

    The Correction to this article has been published in Particle and Fibre Toxicology 2022 19:70

  20. Most toxicological studies on titanium dioxide (TiO2) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis, which is a variety of airspace and int...

    Authors: Shotaro Yamano, Yuko Goto, Tomoki Takeda, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo and Yumi Umeda
    Citation: Particle and Fibre Toxicology 2022 19:58
  21. Over the last two decades, nanotechnologies and the use of nanoparticles represent one of the greatest technological advances in many fields of human activity. Particles of titanium dioxide (TiO2) are one of the ...

    Authors: Eloïse Colnot, Laura Cardoit, Marie-Jeanne Cabirol, Lydia Roudier, Marie-Helene Delville, Anne Fayoux, Muriel Thoby-Brisson, Laurent Juvin and Didier Morin
    Citation: Particle and Fibre Toxicology 2022 19:57
  22. Air pollution has been associated with neurodevelopmental disorders in epidemiological studies. In our studies in mice, developmental exposures to ambient ultrafine particulate (UFP) matter either postnatally ...

    Authors: Marissa Sobolewski, Katherine Conrad, Elena Marvin, Matthew Eckard, Calla M. Goeke, Alyssa K. Merrill, Kevin Welle, Brian P. Jackson, Robert Gelein, David Chalupa, Günter Oberdörster and Deborah A. Cory-Slechta
    Citation: Particle and Fibre Toxicology 2022 19:56
  23. As an emerging pollutant in the life cycle of plastic products, micro/nanoplastics (M/NPs) are increasingly being released into the natural environment. Substantial concerns have been raised regarding the envi...

    Authors: Jiayu Cao, Qing Yang, Jie Jiang, Tatenda Dalu, Aliaksei Kadushkin, Joginder Singh, Rawil Fakhrullin, Fangjun Wang, Xiaoming Cai and Ruibin Li
    Citation: Particle and Fibre Toxicology 2022 19:55
  24. Metabolic syndrome (MetS) exacerbates susceptibility to inhalation exposures such as particulate air pollution, however, the mechanisms responsible remain unelucidated. Previously, we determined a MetS mouse m...

    Authors: Saeed Alqahtani, Li Xia and Jonathan H. Shannahan
    Citation: Particle and Fibre Toxicology 2022 19:54
  25. The application of titanium dioxide nanoparticles (TiO2 NPs) as food additives poses a risk of oral exposure that may lead to adverse health effects. Even though the substantial evidence supported liver as the ta...

    Authors: Zhangjian Chen, Shuo Han, Pai Zheng, Jiahe Zhang, Shupei Zhou and Guang Jia
    Citation: Particle and Fibre Toxicology 2022 19:53
  26. Inhalation of lead oxide nanoparticles (PbO NPs), which are emitted to the environment by high-temperature technological processes, heavily impairs target organs. These nanoparticles pass through the lung barr...

    Authors: Tereza Smutná, Jana Dumková, Daniela Kristeková, Markéta Laštovičková, Adriena Jedličková, Lucie Vrlíková, Bohumil Dočekal, Lukáš Alexa, Hana Kotasová, Vendula Pelková, Zbyněk Večeřa, Kamil Křůmal, Jiří Petráš, Pavel Coufalík, Dalibor Všianský, Samuel Záchej…
    Citation: Particle and Fibre Toxicology 2022 19:52
  27. While it is known that air borne ultrafine particulate matter (PM) may pass through the pulmonary circulation of blood at the alveolar level between lung and heart and cross the air-blood barrier, the mechanis...

    Authors: Saira Hameed, Kun Pan, Wenhua Su, Miles Trupp, Lan Mi and Jinzhuo Zhao
    Citation: Particle and Fibre Toxicology 2022 19:51
  28. The EU-project GRACIOUS developed an Integrated Approach to Testing and Assessment (IATA) to support grouping high aspect ratio nanomaterials (HARNs) presenting a similar inhalation hazard. Application of grou...

    Authors: Fiona Murphy, Nicklas Raun Jacobsen, Emilio Di Ianni, Helinor Johnston, Hedwig Braakhuis, Willie Peijnenburg, Agnes Oomen, Teresa Fernandes and Vicki Stone
    Citation: Particle and Fibre Toxicology 2022 19:50
  29. The widespread use of nano-biomaterials (NBMs) has increased the chance of human exposure. Although ingestion is one of the major routes of exposure to NBMs, it is not thoroughly studied to date. NBMs are expe...

    Authors: Giulia Antonello, Arianna Marucco, Elena Gazzano, Panagiotis Kainourgios, Costanza Ravagli, Ana Gonzalez-Paredes, Simone Sprio, Esperanza Padín-González, Mahmoud G. Soliman, David Beal, Francesco Barbero, Paolo Gasco, Giovanni Baldi, Marie Carriere, Marco P. Monopoli, Costas A. Charitidis…
    Citation: Particle and Fibre Toxicology 2022 19:49
  30. Epidemiological emerging evidence shows that human exposure to some nanosized materials present in the environment would contribute to the onset and/or progression of Alzheimer’s disease (AD). The cellular and...

    Authors: Luiz W. Ribeiro, Mathéa Pietri, Hector Ardila-Osorio, Anne Baudry, François Boudet-Devaud, Chloé Bizingre, Zaira E. Arellano-Anaya, Anne-Marie Haeberlé, Nicolas Gadot, Sonja Boland, Stéphanie Devineau, Yannick Bailly, Odile Kellermann, Anna Bencsik and Benoit Schneider
    Citation: Particle and Fibre Toxicology 2022 19:48
  31. Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The methodology of building a multi-route PBPK model ...

    Authors: Wei-Chun Chou, Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere, Wolfgang G. Kreyling and Zhoumeng Lin
    Citation: Particle and Fibre Toxicology 2022 19:47
  32. Respirable mineral particles represent a potential health hazard in occupational settings and ambient air. Previous studies show that mineral particles may induce cytotoxicity and inflammatory reactions in vit...

    Authors: Vegard Sæter Grytting, Magne Refsnes, Marit Låg, Eyolf Erichsen, Torkil Sørlie Røhr, Brynhild Snilsberg, Richard Aubrey White and Johan Øvrevik
    Citation: Particle and Fibre Toxicology 2022 19:46
  33. Traffic particulate matter (PM) comprises a mixture of particles from fuel combustion and wear of road pavement, tires and brakes. In countries with low winter temperatures the relative contribution of mineral...

    Authors: Tonje Skuland, Vegard Sæter Grytting, Marit Låg, Rikke Bræmming Jørgensen, Brynhild Snilsberg, Daan L. A. C. Leseman, Alena Kubátová, Jessica Emond, Flemming R. Cassee, Jørn A. Holme, Johan Øvrevik and Magne Refsnes
    Citation: Particle and Fibre Toxicology 2022 19:45
  34. Air pollution, especially fine particulate matter (PM), can cause brain damage, cognitive decline, and an increased risk of neurodegenerative disease, especially alzheimer’s disease (AD). Typical pathological ...

    Authors: Ta-Fu Chen, Sheng-Han Lee, Wan-Ru Zheng, Ching-Chou Hsu, Kuan-Hung Cho, Li-Wei Kuo, Charles C.-K. Chou, Ming-Jang Chiu, Boon Lead Tee and Tsun-Jen Cheng
    Citation: Particle and Fibre Toxicology 2022 19:44
  35. Exposure to ambient fine particulate matter (PM2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM2.5 are highly hazardous; however, the contribution of PM2.5-bound PAHs to PM

    Authors: Chia-Chi Ho, Wei-Te Wu, Yi-Jun Lin, Chen-Yi Weng, Ming-Hsien Tsai, Hui-Ti Tsai, Yu-Cheng Chen, Shaw-Fang Yet and Pinpin Lin
    Citation: Particle and Fibre Toxicology 2022 19:43
  36. Long-term exposure to fine particulate matter (PM2.5) increases susceptibility to chronic respiratory diseases, including inflammation and interstitial fibrosis. However, the regulatory mechanisms by which the im...

    Authors: Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng…
    Citation: Particle and Fibre Toxicology 2022 19:42
  37. Emerging data indicate that prenatal exposure to air pollution may lead to higher susceptibility to several non-communicable diseases. Limited research has been conducted due to difficulties in modelling reali...

    Authors: Eva Guilloteau, Patrice Coll, Zhuyi Lu, Madjid Djouina, Mathieu Cazaunau, Christophe Waxin, Antonin Bergé, Ségolène Caboche, Aline Gratien, Elie Al Marj, David Hot, Laurent Dubuquoy, David Launay, Cécile Vignal, Sophie Lanone and Mathilde Body-Malapel
    Citation: Particle and Fibre Toxicology 2022 19:41
  38. It has been shown that copper oxide nanoparticles (CuO NPs) induce pulmonary toxicity after acute or sub-acute inhalation exposures. However, little is known about the biodistribution and elimination kinetics ...

    Authors: Sudartip Areecheewakul, Andrea Adamcakova-Dodd, Ezazul Haque, Xuefang Jing, David K. Meyerholz, Patrick T. O’Shaughnessy, Peter S. Thorne and Aliasger K. Salem
    Citation: Particle and Fibre Toxicology 2022 19:40
  39. Zinc oxide nanoparticles (ZnO NP) offer beneficial properties for many applications, especially in the food sector. Consequently, as part of the human food chain, they are taken up orally. The toxicological ev...

    Authors: Anna Mittag, Alina Singer, Christian Hoera, Martin Westermann, Alexander Kämpfe and Michael Glei
    Citation: Particle and Fibre Toxicology 2022 19:39
  40. A mounting number of studies have been documenting the carcinogenic potential of multiwalled carbon nanotubes (MWCNTs); however, only a few studies have evaluated the pulmonary carcinogenicity of MWCNTs in viv...

    Authors: Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, Satoshi Yokota, Norihiro Kobayashi, Makoto Ohnishi, Yuko Goto, Takamasa Numano, Hiroyuki Tsuda…
    Citation: Particle and Fibre Toxicology 2022 19:38
  41. TiO2 nanomaterials (NMs) are present in a variety of food and personal hygiene products, and consumers are exposed daily to these NMs through oral exposition. While the bulk of ingested TiO2 NMs are eliminated ra...

    Authors: Pégah Jalili, Benjamin-Christoph Krause, Rachelle Lanceleur, Agnès Burel, Harald Jungnickel, Alfonso Lampen, Peter Laux, Andreas Luch, Valérie Fessard and Kevin Hogeveen
    Citation: Particle and Fibre Toxicology 2022 19:37
  42. Since the introduction of copper based, lead-free frangible (LFF) ammunition to Air Force small arms firing ranges, instructors have reported symptoms including chest tightness, respiratory irritation, and met...

    Authors: Ryan J. McNeilly, Jennifer A. Schwanekamp, Logan S. Hyder, John P. Hatch, Brett T. Edwards, Jacob A. Kirsh, Jerimiah M. Jackson, Thomas Jaworek, Mark M. Methner and Christin M. Duran
    Citation: Particle and Fibre Toxicology 2022 19:36
  43. http://static-content.springer.com/image/art%3A10.1186%2Fs12989-022-00475-w/MediaObjects/12989_2022_475_Figa_HTML.png

    Authors: Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, George Daghlian, Young-Kwon Hong, Yasuhiro Yoshimatsu, Masanori Hirashima…
    Citation: Particle and Fibre Toxicology 2022 19:35

    The original article was published in Particle and Fibre Toxicology 2022 19:27

  44. Alumina nanoparticles (aluminaNPs), which are widely used in a range of daily and medical fields, have been shown to penetrate blood-brain barrier, and distribute and accumulate in different brain areas. Altho...

    Authors: Wei Sun, Jia Li, Xiaoliang Li, Xiao Chen, Yazi Mei, Yang Yang and Lei An
    Citation: Particle and Fibre Toxicology 2022 19:34
  45. Copper oxide (CuO) nanoparticles (NPs) are known to trigger cytotoxicity in a variety of cell models, but the mechanism of cell death remains unknown. Here we addressed the mechanism of cytotoxicity in macroph...

    Authors: Govind Gupta, Francesca Cappellini, Lucian Farcal, Rosalba Gornati, Giovanni Bernardini and Bengt Fadeel
    Citation: Particle and Fibre Toxicology 2022 19:33
  46. The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these mater...

    Authors: Rachel Verdon, Vicki Stone, Fiona Murphy, Emily Christopher, Helinor Johnston, Shareen Doak, Ulla Vogel, Andrea Haase and Ali Kermanizadeh
    Citation: Particle and Fibre Toxicology 2022 19:32
  47. Carbon dot has been widely used in biomedical field as a kind of nanomaterial with low toxicity and high biocompatibility. CDs has demonstrated its unique advantages in assisted drug delivery, target diagnosis...

    Authors: Yanting Pang, Ying Yao, Mengran Yang, Daming Wu, Ying Ma, Yuanjian Zhang and Ting Zhang
    Citation: Particle and Fibre Toxicology 2022 19:31
  48. Considering the expanding industrial applications of carbon nanotubes (CNTs), safety assessment of these materials is far less than needed. Very few long-term in vivo studies have been carried out. This is the...

    Authors: Dina Mourad Saleh, Shengyong Luo, Omnia Hosny Mohamed Ahmed, David B. Alexander, William T. Alexander, Sivagami Gunasekaran, Ahmed M. El-Gazzar, Mohamed Abdelgied, Takamasa Numano, Hiroshi Takase, Makoto Ohnishi, Susumu Tomono, Randa Hussein Abd el Hady, Katsumi Fukamachi, Jun Kanno, Akihiko Hirose…
    Citation: Particle and Fibre Toxicology 2022 19:30
  49. Epidemiological studies have suggested that elevated concentrations of particulate matter (PM) are strongly associated with the incidence of atherosclerosis, however, the underlying cellular and molecular mech...

    Authors: Sujin Ju, Leejin Lim, Young-Jae Ki, Dong-Hyun Choi and Heesang Song
    Citation: Particle and Fibre Toxicology 2022 19:29

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