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  1. There is growing evidence that exposure to small size particulate matter increases the risk of developing cardiovascular disease.

    Authors: Lone Mikkelsen, Majid Sheykhzade, Keld A Jensen, Anne T Saber, Nicklas R Jacobsen, Ulla Vogel, Håkan Wallin, Steffen Loft and Peter Møller

    Citation: Particle and Fibre Toxicology 2011 8:32

    Content type: Research

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  2. Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise mechanisms of particle uptake and generation of inflammatory mediators by alveolar macrophages (AM) are still poorly under...

    Authors: Agnes M Scherbart, Julia Langer, Alexey Bushmelev, Damiёn van Berlo, Petra Haberzettl, Frederik-Jan van Schooten, Annette M Schmidt, Christine R Rose, Roel PF Schins and Catrin Albrecht

    Citation: Particle and Fibre Toxicology 2011 8:31

    Content type: Research

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  3. Obesity can be linked to disease risks such as diabetes and cardiovascular disorders, but recently, the adipose tissue (AT) macrophage also emerges as actively participating in inflammation and immune function...

    Authors: Alexander A Götz, Jan Rozman, Heiko G Rödel, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Martin Klingenspor and Tobias Stoeger

    Citation: Particle and Fibre Toxicology 2011 8:30

    Content type: Research

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  4. Human exposure to nanoparticles (NPs) and environmental bacteria can occur simultaneously. NPs induce inflammatory responses and oxidative stress but may also have immune-suppressive effects, impairing macroph...

    Authors: Jong Sung Kim, Andrea Adamcakova-Dodd, Patrick T O'Shaughnessy, Vicki H Grassian and Peter S Thorne

    Citation: Particle and Fibre Toxicology 2011 8:29

    Content type: Research

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  5. The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-in...

    Authors: Alexander A Götz, Antonio Vidal-Puig, Heiko G Rödel, Martin Hrabé de Angelis and Tobias Stoeger

    Citation: Particle and Fibre Toxicology 2011 8:28

    Content type: Research

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  6. Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the path...

    Authors: Wan-Seob Cho, Rodger Duffin, Sarah EM Howie, Chris J Scotton, William AH Wallace, William MacNee, Mark Bradley, Ian L Megson and Ken Donaldson

    Citation: Particle and Fibre Toxicology 2011 8:27

    Content type: Research

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  7. Ambient particulate matter (PM) exposure is associated with respiratory and cardiovascular morbidity and mortality. To what extent such effects are different for PM obtained from different sources or locations...

    Authors: Maaike Steenhof, Ilse Gosens, Maciej Strak, Krystal J Godri, Gerard Hoek, Flemming R Cassee, Ian S Mudway, Frank J Kelly, Roy M Harrison, Erik Lebret, Bert Brunekreef, Nicole AH Janssen and Raymond HH Pieters

    Citation: Particle and Fibre Toxicology 2011 8:26

    Content type: Research

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  8. Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, inclu...

    Authors: Lifang Hou, Xiao Zhang, Letizia Tarantini, Francesco Nordio, Matteo Bonzini, Laura Angelici, Barbara Marinelli, Giovanna Rizzo, Laura Cantone, Pietro Apostoli, Pier Alberto Bertazzi and Andrea Baccarelli

    Citation: Particle and Fibre Toxicology 2011 8:25

    Content type: Research

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  9. Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health and environmental impac...

    Authors: Xiaojia Wang, Pranita Katwa, Ramakrishna Podila, Pengyu Chen, Pu Chun Ke, Apparao M Rao, Dianne M Walters, Christopher J Wingard and Jared M Brown

    Citation: Particle and Fibre Toxicology 2011 8:24

    Content type: Research

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  10. Acute exposure to elevated levels of environmental particulate matter (PM) is associated with increasing morbidity and mortality rates. These adverse health effects, e.g. culminating in respiratory and cardiov...

    Authors: Susanne Fritsch-Decker, Tanja Both, Sonja Mülhopt, Hanns-Rudolf Paur, Carsten Weiss and Silvia Diabaté

    Citation: Particle and Fibre Toxicology 2011 8:23

    Content type: Research

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  11. Risk, associated with nanomaterial use, is determined by exposure and hazard potential of these materials. Both topics cannot be evaluated absolutely independently. Realistic dose concentrations should be test...

    Authors: Thomas AJ Kuhlbusch, Christof Asbach, Heinz Fissan, Daniel Göhler and Michael Stintz

    Citation: Particle and Fibre Toxicology 2011 8:22

    Content type: Review

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  12. Multi-walled carbon nanotubes (MWCNTs) are new manufactured nanomaterials with a wide spectrum of commercial applications. To address the hypothesis that MWCNTs cause persistent pulmonary pathology, C57BL/6J m...

    Authors: Robert R Mercer, Ann F Hubbs, James F Scabilloni, Liying Wang, Lori A Battelli, Sherri Friend, Vincent Castranova and Dale W Porter

    Citation: Particle and Fibre Toxicology 2011 8:21

    Content type: Research

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  13. Prior studies have demonstrated a link between air pollution and metabolic diseases such as type II diabetes. Changes in adipose tissue and its mitochondrial content/function are closely associated with the de...

    Authors: Zhaobin Xu, Xiaohua Xu, Mianhua Zhong, Ian P Hotchkiss, Ryan P Lewandowski, James G Wagner, Lori A Bramble, Yifeng Yang, Aixia Wang, Jack R Harkema, Morton Lippmann, Sanjay Rajagopalan, Lung-Chi Chen and Qinghua Sun

    Citation: Particle and Fibre Toxicology 2011 8:20

    Content type: Research

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  14. Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tr...

    Authors: Ece A Mutlu, Phillip A Engen, Saul Soberanes, Daniela Urich, Christopher B Forsyth, Recep Nigdelioglu, Sergio E Chiarella, Kathryn A Radigan, Angel Gonzalez, Shriram Jakate, Ali Keshavarzian, GR Scott Budinger and Gökhan M Mutlu

    Citation: Particle and Fibre Toxicology 2011 8:19

    Content type: Research

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  15. The study investigated the distribution of silver after 28 days repeated oral administration of silver nanoparticles (AgNPs) and silver acetate (AgAc) to rats. Oral administration is a relevant route of exposu...

    Authors: Katrin Loeschner, Niels Hadrup, Klaus Qvortrup, Agnete Larsen, Xueyun Gao, Ulla Vogel, Alicja Mortensen, Henrik Rye Lam and Erik H Larsen

    Citation: Particle and Fibre Toxicology 2011 8:18

    Content type: Research

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  16. The most common causes of granulomatous inflammation are persistent pathogens and poorly-degradable irritating materials. A characteristic pathological reaction to intratracheal instillation, pharyngeal aspira...

    Authors: Vanesa C Sanchez, Paula Weston, Aihui Yan, Robert H Hurt and Agnes B Kane

    Citation: Particle and Fibre Toxicology 2011 8:17

    Content type: Research

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  17. Gold nanoparticles are widely used in consumer products, including cosmetics, food packaging, beverages, toothpaste, automobiles, and lubricants. With this increase in consumer products containing gold nanopar...

    Authors: Jae Hyuck Sung, Jun Ho Ji, Jung Duck Park, Moon Yong Song, Kyung Seuk Song, Hyeon Ryol Ryu, Jin Uk Yoon, Ki Soo Jeon, Jayoung Jeong, Beom Seok Han, Yong Hyun Chung, Hee Kyung Chang, Ji Hyun Lee, Dong Won Kim, Bruce J Kelman and Il Je Yu

    Citation: Particle and Fibre Toxicology 2011 8:16

    Content type: Research

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  18. It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersi...

    Authors: Megan J Osmond-McLeod, Craig A Poland, Fiona Murphy, Lynne Waddington, Howard Morris, Stephen C Hawkins, Steve Clark, Rob Aitken, Maxine J McCall and Ken Donaldson

    Citation: Particle and Fibre Toxicology 2011 8:15

    Content type: Research

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  19. Authors: Karin S Hougaard, Petra Jackson, Keld A Jensen, Jens J Sloth, Katrin Löschner, Erik H Larsen, Renie K Birkedal, Anni Vibenholt, Anne-Mette Z Boisen, Håkan Wallin and Ulla Vogel

    Citation: Particle and Fibre Toxicology 2011 8:14

    Content type: Erratum

    Published on:

    The original article was published in Particle and Fibre Toxicology 2010 7:16

  20. Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summariz...

    Authors: Evren Kilinç, Holger Schulz, Gerhardus JAJM Kuiper, Henri MH Spronk, Hugo ten Cate, Swapna Upadhyay, Koustav Ganguly, Tobias Stoeger, Manuela Semmler-Bhenke, Shinji Takenaka, Wolfgang G Kreyling, Mike Pitz, Peter Reitmeir, Annette Peters, Oliver Eickelberg and H Erich Wichmann

    Citation: Particle and Fibre Toxicology 2011 8:12

    Content type: Letter to the Editor

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  21. Increased asthma risk/exacerbation in children and infants is associated with exposure to elevated levels of ultrafine particulate matter (PM). The presence of a newly realized class of pollutants, environment...

    Authors: Shrilatha Balakrishna, Jordy Saravia, Paul Thevenot, Terry Ahlert, Slawo Lominiki, Barry Dellinger and Stephania A Cormier

    Citation: Particle and Fibre Toxicology 2011 8:11

    Content type: Research

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  22. Some manufactured nanoparticles are metal-based and have a wide variety of applications in electronic, engineering and medicine. Until now, many studies have described the potential toxicity of NPs on pulmonar...

    Authors: Igor Pujalté, Isabelle Passagne, Brigitte Brouillaud, Mona Tréguer, Etienne Durand, Céline Ohayon-Courtès and Béatrice L'Azou

    Citation: Particle and Fibre Toxicology 2011 8:10

    Content type: Research

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  23. Engineered nanomaterials display unique properties that may have impact on human health, and thus require a reliable evaluation of their potential toxicity. Here, we performed a standardized in vitro screening of...

    Authors: Alexandra Kroll, Christian Dierker, Christina Rommel, Daniela Hahn, Wendel Wohlleben, Christian Schulze-Isfort, Christian Göbbert, Matthias Voetz, Ferdinand Hardinghaus and Jürgen Schnekenburger

    Citation: Particle and Fibre Toxicology 2011 8:9

    Content type: Research

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  24. With the increasing use of nanomaterials, the need for methods and assays to examine their immunosafety is becoming urgent, in particular for nanomaterials that are deliberately administered to human subjects ...

    Authors: Gertie J Oostingh, Eudald Casals, Paola Italiani, Renato Colognato, René Stritzinger, Jessica Ponti, Tobias Pfaller, Yvonne Kohl, Daniëlla Ooms, Flavia Favilli, Hilde Leppens, Davide Lucchesi, François Rossi, Inge Nelissen, Hagen Thielecke, Victor F Puntes…

    Citation: Particle and Fibre Toxicology 2011 8:8

    Content type: Methodology

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  25. Occupational or environmental exposure to asbestos fibres is associated with pleural and parenchymal lung diseases. A histopathologic hallmark of exposure to asbestos is the presence in lung parenchyma of the ...

    Authors: Lorella Pascolo, Alessandra Gianoncelli, Burkhard Kaulich, Clara Rizzardi, Manuela Schneider, Cristina Bottin, Maurizio Polentarutti, Maya Kiskinova, Antonio Longoni and Mauro Melato

    Citation: Particle and Fibre Toxicology 2011 8:7

    Content type: Research

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  26. To date silica nanoparticles (SNPs) play an important role in modern technology and nanomedicine. SNPs are present in various materials (tyres, electrical and thermal insulation material, photovoltaic faciliti...

    Authors: Jennifer Kasper, Maria I Hermanns, Christoph Bantz, Michael Maskos, Roland Stauber, Christine Pohl, Ronald E Unger and James C Kirkpatrick

    Citation: Particle and Fibre Toxicology 2011 8:6

    Content type: Research

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  27. There is increasing interest in the environmental and health consequences of silver nanoparticles as the use of this material becomes widespread. Although human exposure to nanosilver is increasing, only a few...

    Authors: Larissa V Stebounova, Andrea Adamcakova-Dodd, Jong Sung Kim, Heaweon Park, Patrick T O'Shaughnessy, Vicki H Grassian and Peter S Thorne

    Citation: Particle and Fibre Toxicology 2011 8:5

    Content type: Research

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  28. Numerous engineered nanomaterials (ENMs) exist and new ENMs are being developed. A challenge to nanotoxicology and environmental health and safety is evaluating toxicity of ENMs before they become widely utili...

    Authors: Gang Wang, Abiche H Dewilde, Jianping Zhang, Anoop Pal, Malavika Vashist, Dhimiter Bello, Kenneth A Marx, Susan J Braunhut and Joel M Therrien

    Citation: Particle and Fibre Toxicology 2011 8:4

    Content type: Research

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  29. carbon nanotubes (CNT) can have adverse effects on health. Therefore, minimizing the risk associated with CNT exposure is of crucial importance. The aim of this work was to evaluate if coating multi-walled CNT...

    Authors: Lyes Tabet, Cyrill Bussy, Ari Setyan, Angélique Simon-Deckers, Michel J Rossi, Jorge Boczkowski and Sophie Lanone

    Citation: Particle and Fibre Toxicology 2011 8:3

    Content type: Research

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  30. Concerns over the health effects of nanomaterials in the environment have created a need for microscopy methods capable of examining the biological interactions of nanoparticles (NP). Unfortunately, NP are bey...

    Authors: Eugene A Gibbs-Flournoy, Philip A Bromberg, Thomas PJ Hofer, James M Samet and Robert M Zucker

    Citation: Particle and Fibre Toxicology 2011 8:2

    Content type: Methodology

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  31. Clarifying the physicochemical properties of nanomaterials is crucial for hazard assessment and the safe application of these substances. With this in mind, we analyzed the relationship between particle size a...

    Authors: Hiromi Nabeshi, Tomoaki Yoshikawa, Keigo Matsuyama, Yasutaro Nakazato, Saeko Tochigi, Sayuri Kondoh, Toshiro Hirai, Takanori Akase, Kazuya Nagano, Yasuhiro Abe, Yasuo Yoshioka, Haruhiko Kamada, Norio Itoh, Shin-ichi Tsunoda and Yasuo Tsutsumi

    Citation: Particle and Fibre Toxicology 2011 8:1

    Content type: Research

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  32. Exposure to diesel engine exhaust particles (DEPs) has been associated with several adverse health outcomes in which inflammation seems to play a key role. DEPs contain a range of different inorganic and organ...

    Authors: Annike I Totlandsdal, Flemming R Cassee, Per Schwarze, Magne Refsnes and Marit Låg

    Citation: Particle and Fibre Toxicology 2010 7:41

    Content type: Research

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  33. Despite numerous discussions, workshops, reviews and reports about responsible development of nanotechnology, information describing health and environmental risk of engineered nanoparticles or nanomaterials i...

    Authors: Amela Groso, Alke Petri-Fink, Arnaud Magrez, Michael Riediker and Thierry Meyer

    Citation: Particle and Fibre Toxicology 2010 7:40

    Content type: Review

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  34. Silica nanoparticles (SNPs) are produced on an industrial scale and are an addition to a growing number of commercial products. SNPs also have great potential for a variety of diagnostic and therapeutic applic...

    Authors: Dorota Napierska, Leen CJ Thomassen, Dominique Lison, Johan A Martens and Peter H Hoet

    Citation: Particle and Fibre Toxicology 2010 7:39

    Content type: Review

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  35. Nanoparticle (NP) toxicity testing comes with many challenges. Characterization of the test substance is of crucial importance and in the case of NPs, agglomeration/aggregation state in physiological media nee...

    Authors: Ilse Gosens, Jan Andries Post, Liset JJ de la Fonteyne, Eugene HJM Jansen, John W Geus, Flemming R Cassee and Wim H de Jong

    Citation: Particle and Fibre Toxicology 2010 7:37

    Content type: Research

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  36. The difficulty of directly measuring cellular dose is a significant obstacle to application of target tissue dosimetry for nanoparticle and microparticle toxicity assessment, particularly for in vitro systems. As...

    Authors: Paul M Hinderliter, Kevin R Minard, Galya Orr, William B Chrisler, Brian D Thrall, Joel G Pounds and Justin G Teeguarden

    Citation: Particle and Fibre Toxicology 2010 7:36

    Content type: Research

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  37. Nanotechnology and engineered nanomaterials (ENM) are here to stay. Recent evidence suggests that exposure to environmental particulate matter exacerbates symptoms of asthma. In the present study we investigat...

    Authors: Elina M Rossi, Lea Pylkkänen, Antti J Koivisto, Heli Nykäsenoja, Henrik Wolff, Kai Savolainen and Harri Alenius

    Citation: Particle and Fibre Toxicology 2010 7:35

    Content type: Research

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  38. Numerous studies have shown that air pollutants, including diesel exhaust (DE), reduce host defenses, resulting in decreased resistance to respiratory infections. This study sought to determine if DE exposure ...

    Authors: Kymberly M Gowdy, Quentin T Krantz, Charly King, Elizabeth Boykin, Ilona Jaspers, William P Linak and M Ian Gilmour

    Citation: Particle and Fibre Toxicology 2010 7:34

    Content type: Research

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  39. Welding fumes consist of a wide range of complex metal oxide particles which can be deposited in all regions of the respiratory tract. The welding aerosol is not homogeneous and is generated mostly from the el...

    Authors: Stephen S Leonard, Bean T Chen, Samuel G Stone, Diane Schwegler-Berry, Allison J Kenyon, David Frazer and James M Antonini

    Citation: Particle and Fibre Toxicology 2010 7:32

    Content type: Research

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  40. Accumulating evidence indicate that the degree of dispersion of nanoparticles has a strong influence on their biological activities. The aims of this study were to develop a simple and rapid method of nanopart...

    Authors: Liying Wang, Vincent Castranova, Anurag Mishra, Bean Chen, Robert R Mercer, Diane Schwegler-Berry and Yon Rojanasakul

    Citation: Particle and Fibre Toxicology 2010 7:31

    Content type: Research

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  41. Epidemiological studies suggest that inhalation of carbonaceous particulate matter from biomass combustion increases susceptibility to bacterial pneumonia. In vitro studies report that phagocytosis of carbon blac...

    Authors: Ananth Tellabati, Vitor E Fernandes, Friederike Teichert, Rajinder Singh, Jamie Rylance, Stephen Gordon, Peter W Andrew and Jonathan Grigg

    Citation: Particle and Fibre Toxicology 2010 7:30

    Content type: Research

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  42. Exposure to ambient particles has been shown to be responsible for cardiovascular effects, especially in elderly with cardiovascular disease. The study assessed the association between deceleration capacity (D...

    Authors: Alexandra Schneider, Regina Hampel, Angela Ibald-Mulli, Wojciech Zareba, Georg Schmidt, Raphael Schneider, Regina Rückerl, Jean Philippe Couderc, Betty Mykins, Günter Oberdörster, Gabriele Wölke, Mike Pitz, H Erich Wichmann and Annette Peters

    Citation: Particle and Fibre Toxicology 2010 7:29

    Content type: Research

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  43. Multi-walled carbon nanotubes (MWCNT) are new manufactured nanomaterials with a wide spectrum of commercial applications. The durability and fiber-like dimensions (mean length 3.9 μm long × 49 nm diameter) of ...

    Authors: Robert R Mercer, Ann F Hubbs, James F Scabilloni, Liying Wang, Lori A Battelli, Diane Schwegler-Berry, Vincent Castranova and Dale W Porter

    Citation: Particle and Fibre Toxicology 2010 7:28

    Content type: Research

    Published on:

  44. Several epidemiological studies associated exposure to increased levels of particulate matter in Augsburg, Germany with cardiovascular mortality and morbidity. To elucidate the mechanisms of cardiovascular imp...

    Authors: Swapna Upadhyay, Koustav Ganguly, Tobias Stoeger, Manuela Semmler-Bhenke, Shinji Takenaka, Wolfgang G Kreyling, Mike Pitz, Peter Reitmeir, Annette Peters, Oliver Eickelberg, H Erich Wichmann and Holger Schulz

    Citation: Particle and Fibre Toxicology 2010 7:27

    Content type: Research

    Published on:

  45. Exposures to an amphibole fiber in Libby, Montana cause increases in malignant mesothelioma (MM), a tumor of the pleural and peritoneal cavities with a poor prognosis. Affymetrix microarray/GeneSifter analysis...

    Authors: Jedd M Hillegass, Arti Shukla, Maximilian B MacPherson, Sherrill A Lathrop, Vlada Alexeeva, Timothy N Perkins, Albert van der Vliet, Pamela M Vacek, Mickey E Gunter and Brooke T Mossman

    Citation: Particle and Fibre Toxicology 2010 7:26

    Content type: Research

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  46. Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was ...

    Authors: Sourav Bhattacharjee, Laura HJ de Haan, Nynke M Evers, Xue Jiang, Antonius TM Marcelis, Han Zuilhof, Ivonne MCM Rietjens and Gerrit M Alink

    Citation: Particle and Fibre Toxicology 2010 7:25

    Content type: Research

    Published on:

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