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  1. Metal oxide nanoparticles such as ZnO are used in sunscreens as they improve their optical properties against the UV-light that causes dermal damage and skin cancer. However, the hazardous properties of the pa...

    Authors: Marit Ilves, Jaana Palomäki, Minnamari Vippola, Maili Lehto, Kai Savolainen, Terhi Savinko and Harri Alenius
    Citation: Particle and Fibre Toxicology 2014 11:38
  2. Diabetes may confer an increased risk for the cardiovascular health effects of particulate air pollution, but few human clinical studies of air pollution have included people with diabetes. Ultrafine particles...

    Authors: Rathin Vora, Wojciech Zareba, Mark J Utell, Anthony P Pietropaoli, David Chalupa, Erika L Little, David Oakes, Jan Bausch, Jelani Wiltshire and Mark W Frampton
    Citation: Particle and Fibre Toxicology 2014 11:31
  3. The aim of this study was to obtain kinetic data that can be used in human risk assessment of titanium dioxide nanomaterials.

    Authors: Liesbeth Geraets, Agnes G Oomen, Petra Krystek, Nicklas R Jacobsen, Håkan Wallin, Michel Laurentie, Henny W Verharen, Esther FA Brandon and Wim H de Jong
    Citation: Particle and Fibre Toxicology 2014 11:30
  4. Emissions from a large peat fire in North Carolina in 2008 were associated with increased hospital admissions for asthma and the rate of heart failure in the exposed population. Peat fires often produce larger...

    Authors: Yong Ho Kim, Haiyan Tong, Mary Daniels, Elizabeth Boykin, Q Todd Krantz, John McGee, Michael Hays, Kasey Kovalcik, Janice A Dye and M Ian Gilmour
    Citation: Particle and Fibre Toxicology 2014 11:29
  5. In vivo studies have demonstrated the ability of multi-walled carbon nanotubes (MWCNT) to induce airway remodeling, a key feature of chronic respiratory diseases like asthma and chronic obstructive pulmonary dise...

    Authors: Salik Hussain, Stacey Sangtian, Shamika M Anderson, Ryan J Snyder, Jamie D Marshburn, Annette B Rice, James C Bonner and Stavros Garantziotis
    Citation: Particle and Fibre Toxicology 2014 11:28
  6. Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter, PM2.5) and development of insulin resistance/Type II diabetes mellitu...

    Authors: Cuiqing Liu, Yuntao Bai, Xiaohua Xu, Lixian Sun, Aixia Wang, Tse-Yao Wang, Santosh K Maurya, Muthu Periasamy, Masako Morishita, Jack Harkema, Zhekang Ying, Qinghua Sun and Sanjay Rajagopalan
    Citation: Particle and Fibre Toxicology 2014 11:27
  7. Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Holl...

    Authors: Jian You, Jialin Zhou, Min Zhou, Yang Liu, J David Robertson, Dong Liang, Carolyn Van Pelt and Chun Li
    Citation: Particle and Fibre Toxicology 2014 11:26
  8. We tested the hypothesis that cardiovascular responses to PM2.5 exposure will be enhanced in hypertensive rats and linked to specific carbonaceous pollutants in an urban industrial setting.

    Authors: James G Wagner, Ali S Kamal, Masako Morishita, J Timothy Dvonch, Jack R Harkema and Annette C Rohr
    Citation: Particle and Fibre Toxicology 2014 11:25
  9. Asbestos exposure is related to various diseases including asbestosis and malignant mesothelioma (MM). Among the pathogenic mechanisms proposed by which asbestos can cause diseases involving epithelial and mes...

    Authors: Joyce K Thompson, Catherine M Westbom, Maximilian B MacPherson, Brooke T Mossman, Nicholas H Heintz, Page Spiess and Arti Shukla
    Citation: Particle and Fibre Toxicology 2014 11:24
  10. Although major concerns exist regarding the potential consequences of human exposure to nanoparticles (NP), no human toxicological data is currently available. To address this issue, we took welders, who prese...

    Authors: Pascal Andujar, Angélique Simon-Deckers, Françoise Galateau-Sallé, Barbara Fayard, Gregory Beaune, Bénédicte Clin, Marie-Annick Billon-Galland, Olivier Durupthy, Jean-Claude Pairon, Jean Doucet, Jorge Boczkowski and Sophie Lanone
    Citation: Particle and Fibre Toxicology 2014 11:23
  11. Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects are a major concern. The objective of this stu...

    Authors: Sudjit Luanpitpong, Liying Wang, Vincent Castranova and Yon Rojanasakul
    Citation: Particle and Fibre Toxicology 2014 11:22
  12. Nanosilver is used in a variety of medical and consumer products because of its antibacterial activity. This wide application results in an increased human exposure. Knowledge on the systemic toxicity of nanos...

    Authors: Rob J Vandebriel, Elisa CM Tonk, Liset J de la Fonteyne-Blankestijn, Eric R Gremmer, Henny W Verharen, Leo T van der Ven, Henk van Loveren and Wim H de Jong
    Citation: Particle and Fibre Toxicology 2014 11:21
  13. There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular...

    Authors: Joel M Cohen, Justin G Teeguarden and Philip Demokritou
    Citation: Particle and Fibre Toxicology 2014 11:20

    The Related Article to this article has been published in Nature Protocols 2017 12:nprot.2016.172

  14. Persons with cystic fibrosis (CF) are at-risk for health effects from ambient air pollution but little is known about the interaction of nanoparticles (NP) with CF lungs. Here we study the distribution of inha...

    Authors: Marianne Geiser, Tobias Stoeger, Marco Casaulta, Shanze Chen, Manuela Semmler-Behnke, Ines Bolle, Shinji Takenaka, Wolfgang G Kreyling and Holger Schulz
    Citation: Particle and Fibre Toxicology 2014 11:19
  15. The increasing manufacture and use of products based on nanotechnology raises concerns for both workers and consumers. Various studies report induction of pulmonary inflammation after inhalation exposure to na...

    Authors: Hedwig M Braakhuis, Margriet VDZ Park, Ilse Gosens, Wim H De Jong and Flemming R Cassee
    Citation: Particle and Fibre Toxicology 2014 11:18
  16. Advances in adding nanomaterials to various matrices have occurred in tandem with the identification of potential hazards associated with exposure to pure forms of nanomaterials. We searched multiple research ...

    Authors: Stephan J Froggett, Shaun F Clancy, Darrell R Boverhof and Richard A Canady
    Citation: Particle and Fibre Toxicology 2014 11:17
  17. A standard short-term inhalation study (STIS) was applied for hazard assessment of 13 metal oxide nanomaterials and micron-scale zinc oxide.

    Authors: Robert Landsiedel, Lan Ma-Hock, Thomas Hofmann, Martin Wiemann, Volker Strauss, Silke Treumann, Wendel Wohlleben, Sibylle Gröters, Karin Wiench and Bennard van Ravenzwaay
    Citation: Particle and Fibre Toxicology 2014 11:16
  18. Although ZnO nanoparticles (NPs) are used in many commercial products and the potential for human exposure is increasing, few in vivo studies have addressed their possible toxic effects after inhalation. We sough...

    Authors: Andrea Adamcakova-Dodd, Larissa V Stebounova, Jong Sung Kim, Sabine U Vorrink, Andrew P Ault, Patrick T O’Shaughnessy, Vicki H Grassian and Peter S Thorne
    Citation: Particle and Fibre Toxicology 2014 11:15
  19. The mechanisms of toxicity of metal oxide particles towards lung cells are far from being understood. In particular, the relative contribution of intracellular particulate versus solubilized fractions is rarel...

    Authors: Richard Ortega, Carole Bresson, Carine Darolles, Céline Gautier, Stéphane Roudeau, Laura Perrin, Myriam Janin, Magali Floriani, Valérie Aloin, Asuncion Carmona and Véronique Malard
    Citation: Particle and Fibre Toxicology 2014 11:14
  20. TiO2 particles are commonly used as dietary supplements and may contain up to 36% of nano-sized particles (TiO2-NPs). Still impact and translocation of NPs through the gut epithelium is poorly documented.

    Authors: Emilie Brun, Frédérick Barreau, Giulia Veronesi, Barbara Fayard, Stéphanie Sorieul, Corinne Chanéac, Christine Carapito, Thierry Rabilloud, Aloïse Mabondzo, Nathalie Herlin-Boime and Marie Carrière
    Citation: Particle and Fibre Toxicology 2014 11:13
  21. Clinical studies have now confirmed the link between short-term exposure to elevated levels of air pollution and increased cardiovascular mortality, but the mechanisms are complex and not completely elucidated...

    Authors: Sarah Robertson, Ashleigh L Thomson, Rod Carter, Holly R Stott, Catherine A Shaw, Patrick W F Hadoke, David E Newby, Mark R Miller and Gillian A Gray
    Citation: Particle and Fibre Toxicology 2014 11:12
  22. Silver nanoparticles (AgNPs) are currently one of the most manufactured nanomaterials. A wide range of toxicity studies have been performed on various AgNPs, but these studies report a high variation in toxici...

    Authors: Anda R Gliga, Sara Skoglund, Inger Odnevall Wallinder, Bengt Fadeel and Hanna L Karlsson
    Citation: Particle and Fibre Toxicology 2014 11:11
  23. Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts or antimicrobial additives. This increases the risk of adverse health effects, since copper ions are cytotoxic ...

    Authors: Annetta Semisch, Julia Ohle, Barbara Witt and Andrea Hartwig
    Citation: Particle and Fibre Toxicology 2014 11:10
  24. To assess the risk of all nanomaterials (NMs) on a case-by-case basis is challenging in terms of financial, ethical and time resources. Instead a more intelligent approach to knowledge gain and risk assessment...

    Authors: Vicki Stone, Stefano Pozzi-Mucelli, Lang Tran, Karin Aschberger, Stefania Sabella, Ulla Vogel, Craig Poland, Dominique Balharry, Teresa Fernandes, Stefania Gottardo, Steven Hankin, Mark GJ Hartl, Nanna Hartmann, Danial Hristozov, Kerstin Hund-Rinke, Helinor Johnston…
    Citation: Particle and Fibre Toxicology 2014 11:9
  25. Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano...

    Authors: Meike van der Zande, Rob J Vandebriel, Maria J Groot, Evelien Kramer, Zahira E Herrera Rivera, Kirsten Rasmussen, Jan S Ossenkoppele, Peter Tromp, Eric R Gremmer, Ruud JB Peters, Peter J Hendriksen, Hans JP Marvin, Ron LAP Hoogenboom, Ad ACM Peijnenburg and Hans Bouwmeester
    Citation: Particle and Fibre Toxicology 2014 11:8
  26. Nickel nanoparticles (NiNPs) are increasingly used in a variety of industrial applications, including the manufacturing of multi-walled carbon nanotubes (MWCNTs). While occupational nickel exposure is a known ...

    Authors: Ellen E Glista-Baker, Alexia J Taylor, Brian C Sayers, Elizabeth A Thompson and James C Bonner
    Citation: Particle and Fibre Toxicology 2014 11:7
  27. Carbon nanotubes are commercially-important products of nanotechnology; however, their low density and small size makes carbon nanotube respiratory exposures likely during their production or processing. We ha...

    Authors: Katelyn J Siegrist, Steven H Reynolds, Michael L Kashon, David T Lowry, Chenbo Dong, Ann F Hubbs, Shih-Houng Young, Jeffrey L Salisbury, Dale W Porter, Stanley A Benkovic, Michael McCawley, Michael J Keane, John T Mastovich, Kristin L Bunker, Lorenzo G Cena, Mark C Sparrow…
    Citation: Particle and Fibre Toxicology 2014 11:6
  28. The increased production of nanomaterials has caused a corresponding increase in concern about human exposures in consumer and occupational settings. Studies in rodents have evaluated dose–response relationshi...

    Authors: Brittany L Baisch, Nancy M Corson, Pamela Wade-Mercer, Robert Gelein, Andrea J Kennell, Günter Oberdörster and Alison Elder
    Citation: Particle and Fibre Toxicology 2014 11:5
  29. Certain multi-walled carbon nanotubes (MWCNTs) have been shown to elicit asbestos-like toxicological effects. To reduce needs for risk assessment it has been suggested that the physicochemical characteristics ...

    Authors: Penny Nymark, Keld Alstrup Jensen, Satu Suhonen, Yahia Kembouche, Minnamari Vippola, Jos Kleinjans, Julia Catalán, Hannu Norppa, Joost van Delft and Jacob Jan Briedé
    Citation: Particle and Fibre Toxicology 2014 11:4
  30. Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are a...

    Authors: Linda M Sargent, Dale W Porter, Lauren M Staska, Ann F Hubbs, David T Lowry, Lori Battelli, Katelyn J Siegrist, Michael L Kashon, Robert R Mercer, Alison K Bauer, Bean T Chen, Jeffrey L Salisbury, David Frazer, Walter McKinney, Michael Andrew, Shuji Tsuruoka…
    Citation: Particle and Fibre Toxicology 2014 11:3
  31. An abnormally high incidence of lung disease has been observed in the residents of Libby, Montana, which has been attributed to occupational and environmental exposure to fibrous amphiboles originating from a ...

    Authors: Kelly E Duncan, Philip M Cook, Stephen H Gavett, Lisa A Dailey, Ron K Mahoney, Andrew J Ghio, Victor L Roggli and Robert B Devlin
    Citation: Particle and Fibre Toxicology 2014 11:2
  32. We and others have shown that increases in particulate air pollutant (PM) concentrations in the previous hours and days have been associated with increased risks of myocardial infarction, but little is known a...

    Authors: Blake Gardner, Frederick Ling, Philip K Hopke, Mark W Frampton, Mark J Utell, Wojciech Zareba, Scott J Cameron, David Chalupa, Cathleen Kane, Suresh Kulandhaisamy, Michael C Topf and David Q Rich
    Citation: Particle and Fibre Toxicology 2014 11:1
  33. Ultrasonic humidifiers silently generate water droplets as a cool fog and produce most of the dissolved minerals in the fog in the form of an aerosolized “white dust.” However, the health effect of these airbo...

    Authors: Masakazu Umezawa, Keisuke Sekita, Ken-ichiro Suzuki, Miyoko Kubo-Irie, Rikio Niki, Tomomi Ihara, Masao Sugamata and Ken Takeda
    Citation: Particle and Fibre Toxicology 2013 10:64
  34. This study explores and characterizes cell cycle alterations induced by urban PM2.5 in the human epithelial cell line BEAS-2B, and elucidates possible mechanisms involved.

    Authors: Eleonora Longhin, Jørn A Holme, Kristine B Gutzkow, Volker M Arlt, Jill E Kucab, Marina Camatini and Maurizio Gualtieri
    Citation: Particle and Fibre Toxicology 2013 10:63
  35. Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. Whi...

    Authors: Hannah A Oppenheim, JoAnn Lucero, Anne-Cécile Guyot, Lindsay M Herbert, Jacob D McDonald, Aloïse Mabondzo and Amie K Lund
    Citation: Particle and Fibre Toxicology 2013 10:62
  36. Diesel exhaust particulate (DEP), a major component of urban air pollution, has been linked to atherogenesis and precipitation of myocardial infarction. We hypothesized that DEP exposure would increase and des...

    Authors: Mark R Miller, Steven G McLean, Rodger Duffin, Akeem O Lawal, Jesus A Araujo, Catherine A Shaw, Nicholas L Mills, Ken Donaldson, David E Newby and Patrick WF Hadoke
    Citation: Particle and Fibre Toxicology 2013 10:61
  37. Exposure to diesel exhaust causes inflammatory responses. Previous controlled exposure studies at a concentration of 300 μg/m3 of diesel exhaust particles mainly lasted for 1 h. We prolonged the exposure period a...

    Authors: Yiyi Xu, Lars Barregard, Jörn Nielsen, Anders Gudmundsson, Aneta Wierzbicka, Anna Axmon, Bo AG Jönsson, Monica Kåredal and Maria Albin
    Citation: Particle and Fibre Toxicology 2013 10:60
  38. Fine particulate air pollution (PM2.5) is a global health concern, as exposure to PM2.5 has consistently been found to be associated with increased cardiovascular morbidity and mortality. Although adult exposure ...

    Authors: Chad S Weldy, Yonggang Liu, Yu-Chi Chang, Ivan O Medvedev, Julie R Fox, Timothy V Larson, Wei-Ming Chien and Michael T Chin
    Citation: Particle and Fibre Toxicology 2013 10:59
  39. Increased susceptibility of smokers to ambient PM may potentially promote development of COPD and accelerate already present disease.

    Authors: Milan J Hazucha, Philip A Bromberg, John C Lay, William Bennett, Kirby Zeman, Neil E Alexis, Howard Kehrl, Ana G Rappold, Wayne E Cascio and Robert B Devlin
    Citation: Particle and Fibre Toxicology 2013 10:58
  40. Several properties of multi-walled carbon nanotubes (MWCNT) have the potential to affect their bioactivity. This study examined the in vitro and in vivo outcomes of the influence of diameter, length, purification...

    Authors: Raymond F Hamilton Jr, Zheqiong Wu, Somenath Mitra, Pamela K Shaw and Andrij Holian
    Citation: Particle and Fibre Toxicology 2013 10:57
  41. Many toxicological studies on silica nanoparticles (NPs) have been reported, however, the literature often shows various conclusions concerning the same material. This is mainly due to a lack of sufficient NPs...

    Authors: Emilia Izak-Nau, Matthias Voetz, Stefanie Eiden, Albert Duschl and Victor F Puntes
    Citation: Particle and Fibre Toxicology 2013 10:56
  42. Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs ma...

    Authors: Wan-Seob Cho, Rodger Duffin, Mark Bradley, Ian L Megson, William MacNee, Jong Kwon Lee, Jayoung Jeong and Ken Donaldson
    Citation: Particle and Fibre Toxicology 2013 10:55
  43. Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which ...

    Authors: Megan J Osmond-McLeod, Ronald IW Osmond, Yalchin Oytam, Maxine J McCall, Bryce Feltis, Alan Mackay-Sim, Stephen A Wood and Anthony L Cook
    Citation: Particle and Fibre Toxicology 2013 10:54
  44. Dosimetry for toxicology studies involving carbon nanotubes (CNT) is challenging because of a lack of detailed occupational exposure assessments. Therefore, exposure assessment findings, measuring the mass con...

    Authors: Aaron Erdely, Matthew Dahm, Bean T Chen, Patti C Zeidler-Erdely, Joseph E Fernback, M Eileen Birch, Douglas E Evans, Michael L Kashon, James A Deddens, Tracy Hulderman, Suzan A Bilgesu, Lori Battelli, Diane Schwegler-Berry, Howard D Leonard, Walter McKinney, David G Frazer…
    Citation: Particle and Fibre Toxicology 2013 10:53
  45. Carbon nanotubes (CNT) can induce lung inflammation and fibrosis in rodents. Several studies have identified the capacity of CNT to stimulate the proliferation of fibroblasts. We developed and validated experi...

    Authors: Giulia Vietti, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Yousof Yakoub, Christian Bailly, Ivana Fenoglio, Etienne Marbaix, Dominique Lison and Sybille van den Brule
    Citation: Particle and Fibre Toxicology 2013 10:52
  46. Authors: Suxin Gui, Xuezi Sang, Lei Zheng, Yuguan Ze, Xiaoyang Zhao, Lei Sheng, Qingqing Sun, Zhe Cheng, Jie Cheng, Renping Hu, Ling Wang, Fashui Hong and Meng Tang
    Citation: Particle and Fibre Toxicology 2013 10:51

    The original article was published in Particle and Fibre Toxicology 2013 10:4

  47. Reliable in vitro toxicity testing is needed prior to the commencement of in vivo testing necessary for hazard identification and risk assessment of nanoparticles. In this study, the cytotoxicity and uptake of 14...

    Authors: Melissa A Vetten, Nonhlanhla Tlotleng, Delia Tanner Rascher, Amanda Skepu, Frankline K Keter, Kailen Boodhia, Leigh-Anne Koekemoer, Charlene Andraos, Robert Tshikhudo and Mary Gulumian
    Citation: Particle and Fibre Toxicology 2013 10:50
  48. Strong associations have been observed between exposure to fine ambient particulate matter (PM2.5) and adverse cardiovascular outcomes. In particular, exposure to traffic related PM2.5 has been associated with in...

    Authors: Yonggang Liu, Wei-Ming Chien, Ivan O Medvedev, Chad S Weldy, Daniel L Luchtel, Michael E Rosenfeld and Michael T Chin
    Citation: Particle and Fibre Toxicology 2013 10:49
  49. The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biolo...

    Authors: Alexandra Noël, Michel Charbonneau, Yves Cloutier, Robert Tardif and Ginette Truchon
    Citation: Particle and Fibre Toxicology 2013 10:48

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