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  1. Content type: Research

    Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of products, including rubber manufacture, cosmetics, pigments, food additives, medicine, chemical fibers and electronics. However, the molec...

    Authors: Yuh-Feng Lin, I-Jen Chiu, Fong-Yu Cheng, Yu-Hsuan Lee, Ying-Jan Wang, Yung-Ho Hsu and Hui-Wen Chiu

    Citation: Particle and Fibre Toxicology 2016 13:52

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  2. Content type: Research

    The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays de...

    Authors: John W. Wills, Nicole Hondow, Adam D. Thomas, Katherine E. Chapman, David Fish, Thierry G. Maffeis, Mark W. Penny, Richard A. Brown, Gareth J. S. Jenkins, Andy P. Brown, Paul A. White and Shareen H. Doak

    Citation: Particle and Fibre Toxicology 2016 13:50

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  3. Content type: Research

    The rapidly increasing number of engineered nanoparticles (NPs), and products containing NPs, raises concerns for human exposure and safety. With this increasing, and ever changing, catalogue of NPs it is beco...

    Authors: Matthew S. P. Boyles, Christina Ranninger, Roland Reischl, Marc Rurik, Richard Tessadri, Oliver Kohlbacher, Albert Duschl and Christian G. Huber

    Citation: Particle and Fibre Toxicology 2016 13:49

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  4. Content type: Research

    The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the abili...

    Authors: Nathan A. Holland, Leslie C. Thompson, Achini K. Vidanapathirana, Rahkee N. Urankar, Robert M. Lust, Timothy R. Fennell and Christopher J. Wingard

    Citation: Particle and Fibre Toxicology 2016 13:48

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  5. Content type: Research

    The constant increase of the use of nanomaterials in consumer products is making increasingly urgent that standardized and reliable in vitro test methods for toxicity screening be made available to the scienti...

    Authors: Grigore Rischitor, Mariantonietta Parracino, Rita La Spina, Patrizia Urbán, Isaac Ojea-Jiménez, Elena Bellido, Andrea Valsesia, Sabrina Gioria, Robin Capomaccio, Agnieszka Kinsner-Ovaskainen, Douglas Gilliland, François Rossi and Pascal Colpo

    Citation: Particle and Fibre Toxicology 2016 13:47

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    The Erratum to this article has been published in Particle and Fibre Toxicology 2016 13:66

  6. Content type: Research

    The asbestos-like toxicity of some engineered carbon nanotubes (CNT), notably their capacity to induce mesothelioma, is a serious cause of concern for public health. Here we show that carcinogenic CNT induce a...

    Authors: François Huaux, Virginie d’Ursel de Bousies, Marie-Astrid Parent, Micaela Orsi, Francine Uwambayinema, Raynal Devosse, Saloua Ibouraadaten, Yousof Yakoub, Nadtha Panin, Mihaly Palmai-Pallag, Pierre van der Bruggen, Christian Bailly, Riccardo Marega, Etienne Marbaix and Dominique Lison

    Citation: Particle and Fibre Toxicology 2016 13:46

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  7. Content type: Research

    Cerium oxide (CeO2) nanoparticles used as a diesel fuel additive can be emitted into the ambient air leading to human inhalation. Although biological studies have shown CeO2 nanoparticles can cause adverse health...

    Authors: Dingsheng Li, Masako Morishita, James G. Wagner, Mohammad Fatouraie, Margaret Wooldridge, W. Ethan Eagle, James Barres, Ulrika Carlander, Claude Emond and Olivier Jolliet

    Citation: Particle and Fibre Toxicology 2016 13:45

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  8. Content type: Research

    The application of sunscreen is a critical component of a sun-safe strategy, however the possibility of unexpected, adverse outcomes resulting from long-term use of sunscreens containing nanoparticles of titan...

    Authors: Megan J. Osmond-McLeod, Yalchin Oytam, Anthony Rowe, Fariborz Sobhanmanesh, Gavin Greenoak, Jason Kirby, Elizabeth F. McInnes and Maxine J. McCall

    Citation: Particle and Fibre Toxicology 2016 13:44

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  9. Content type: Research

    Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in di...

    Authors: Jennifer D. Sisler, Ruibin Li, Walter McKinney, Robert R. Mercer, Zhaoxia Ji, Tian Xia, Xiang Wang, Justine Shaffer, Marlene Orandle, Amy L. Mihalchik, Lori Battelli, Bean T. Chen, Michael Wolfarth, Michael E. Andrew, Diane Schwegler-Berry, Dale W. Porter…

    Citation: Particle and Fibre Toxicology 2016 13:42

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  10. Content type: Research

    Association of particulate matter with adverse health effects has been established in epidemiological studies and animal experiments. Epidemiological studies are difficult to undertake while animal studies are...

    Authors: Dalibor Breznan, Subramanian Karthikeyan, Marcelle Phaneuf, Prem Kumarathasan, Sabit Cakmak, Michael S. Denison, Jeffrey R. Brook and Renaud Vincent

    Citation: Particle and Fibre Toxicology 2016 13:41

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  11. Content type: Review

    The innate immune system is the first line of defense against inhaled particles. Macrophages serve important roles in particle clearance and inflammatory reactions. Following recognition and internalization by...

    Authors: Virginie Rabolli, Dominique Lison and François Huaux

    Citation: Particle and Fibre Toxicology 2016 13:40

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  12. Content type: Research

    Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to airborne pollution, in particular diese...

    Authors: Sarah A. Valentino, Anne Tarrade, Josiane Aioun, Eve Mourier, Christophe Richard, Michèle Dahirel, Delphine Rousseau-Ralliard, Natalie Fournier, Marie-Christine Aubrière, Marie-Sylvie Lallemand, Sylvaine Camous, Marine Guinot, Madia Charlier, Etienne Aujean, Hala Al Adhami, Paul H. Fokkens…

    Citation: Particle and Fibre Toxicology 2016 13:39

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  13. Content type: Research

    Humans are increasingly exposed via the diet to Ag nanoparticles (NP) used in the food industry. Because of their anti-bacterial activity, ingested Ag NP might disturb the gut microbiota that is essential for ...

    Authors: Sybille van den Brule, Jérôme Ambroise, Hélène Lecloux, Clément Levard, Romain Soulas, Pieter-Jan De Temmerman, Mihaly Palmai-Pallag, Etienne Marbaix and Dominique Lison

    Citation: Particle and Fibre Toxicology 2016 13:38

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  14. Content type: Research

    The toxicity of dusts from mechanical abrasion of multi-walled carbon nanotube (CNT) epoxy nanocomposites is unknown. We compared the toxic effects of dusts generated by sanding of epoxy composites with and wi...

    Authors: Anne Thoustrup Saber, Alicja Mortensen, Józef Szarek, Ismo Kalevi Koponen, Marcus Levin, Nicklas Raun Jacobsen, Maria Elena Pozzebon, Stefano Pozzi Mucelli, David George Rickerby, Kirsten Kling, Rambabu Atluri, Anne Mette Madsen, Petra Jackson, Zdenka Orabi Kyjovska, Ulla Vogel, Keld Alstrup Jensen…

    Citation: Particle and Fibre Toxicology 2016 13:37

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  15. Content type: Research

    There is growing evidence that exposure to titanium dioxide nanoparticles (TiO2 NPs) could be harmful. Previously, we have shown that TiO2 NPs induces endothelial cell dysfunction and damage in glial cells. Consi...

    Authors: Cristhiam Rueda-Romero, Guillermina Hernández-Pérez, Pilar Ramos-Godínez, Inés Vázquez-López, Raúl Omar Quintana-Belmares, Elizabeth Huerta-García, Ewa Stepien, Rebeca López-Marure, Angélica Montiel-Dávalos and Ernesto Alfaro-Moreno

    Citation: Particle and Fibre Toxicology 2016 13:36

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  16. Content type: Research

    Graphene, a monolayer of carbon, is an engineered nanomaterial (ENM) with physical and chemical properties that may offer application advantages over other carbonaceous ENMs, such as carbon nanotubes (CNT). Th...

    Authors: Jenny R. Roberts, Robert R. Mercer, Aleksandr B. Stefaniak, Mohindar S. Seehra, Usha K. Geddam, Ishrat S. Chaudhuri, Angelos Kyrlidis, Vamsi K. Kodali, Tina Sager, Allison Kenyon, Suzan A. Bilgesu, Tracy Eye, James F. Scabilloni, Stephen S. Leonard, Natalie R. Fix, Diane Schwegler-Berry…

    Citation: Particle and Fibre Toxicology 2016 13:34

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  17. Content type: Research

    Carbonaceous nanoparticles (CNP) represent a major constituent of urban particulate air pollution, and inhalation of high CNP levels has been described to trigger a pro-inflammatory response of the lung. While...

    Authors: Shanze Chen, Renfu Yin, Kathrin Mutze, Youjia Yu, Shinji Takenaka, Melanie Königshoff and Tobias Stoeger

    Citation: Particle and Fibre Toxicology 2016 13:33

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  18. Content type: Research

    Exposure to some - but not all - quartz particles is associated to silicosis, lung cancer and autoimmune diseases. What imparts pathogenicity to any single quartz source is however still unclear. Crystallinity...

    Authors: Francesco Turci, Cristina Pavan, Riccardo Leinardi, Maura Tomatis, Linda Pastero, David Garry, Sergio Anguissola, Dominique Lison and Bice Fubini

    Citation: Particle and Fibre Toxicology 2016 13:32

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  19. Content type: Research

    Tungsten inert gas (TIG) welding represents one of the most widely used metal joining processes in industry. It has been shown to generate a large majority of particles at the nanoscale and to have low mass em...

    Authors: Halshka Graczyk, Nastassja Lewinski, Jiayuan Zhao, Jean-Jacques Sauvain, Guillaume Suarez, Pascal Wild, Brigitta Danuser and Michael Riediker

    Citation: Particle and Fibre Toxicology 2016 13:31

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  20. Content type: Research

    Instillation of highly soluble nanoparticles (NPs) into the lungs of rodents can cause acute eosinophilia without any previous sensitizations by the role of dissolved ions. However, whether gradually dissolvin...

    Authors: Seonghan Lee, Sung-Hyun Hwang, Jiyoung Jeong, Youngju Han, Sung-Hyun Kim, Dong-Keon Lee, Hae-Suk Lee, Seung-Tae Chung, Jayoung Jeong, Changhyun Roh, Yun Seok Huh and Wan-Seob Cho

    Citation: Particle and Fibre Toxicology 2016 13:30

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  21. Content type: Research

    Atomic layer deposition (ALD) is a method for applying conformal nanoscale coatings on three-dimensional structures. We hypothesized that surface functionalization of multi-walled carbon nanotubes (MWCNTs) wit...

    Authors: Erinn C. Dandley, Alexia J. Taylor, Katherine S. Duke, Mark D. Ihrie, Kelly A. Shipkowski, Gregory N. Parsons and James C. Bonner

    Citation: Particle and Fibre Toxicology 2016 13:29

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  22. Content type: Research

    Cellulose-based materials have been used for centuries to manufacture different goods derived from forestry and agricultural sources. In the growing field of nanocellulose applications, its uniquely engineered...

    Authors: Anna A. Shvedova, Elena R. Kisin, Naveena Yanamala, Mariana T. Farcas, Autumn L. Menas, Andrew Williams, Philip M. Fournier, Jeffrey S. Reynolds, Dmitriy W. Gutkin, Alexander Star, Richard S. Reiner, Sabina Halappanavar and Valerian E. Kagan

    Citation: Particle and Fibre Toxicology 2016 13:28

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  23. Content type: Research

    Multi-walled carbon nanotubes (MWCNT) are currently under intense toxicological investigation due to concern on their potential health effects. Current in vitro and in vivo data indicate that MWCNT exposure is...

    Authors: Manuela Polimeni, Giulia Rossana Gulino, Elena Gazzano, Joanna Kopecka, Arianna Marucco, Ivana Fenoglio, Federico Cesano, Luisa Campagnolo, Andrea Magrini, Antonio Pietroiusti, Dario Ghigo and Elisabetta Aldieri

    Citation: Particle and Fibre Toxicology 2016 13:27

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  24. Content type: Research

    Exposures to ambient particulate matter (PM) are associated with increased morbidity and mortality. PM2.5 (<2.5 μm) and ozone exposures have been shown to associate with carotid intima media thickness in humans. ...

    Authors: Gajalakshmi Ramanathan, Fen Yin, Mary Speck, Chi-hong Tseng, Jeffrey R. Brook, Frances Silverman, Bruce Urch, Robert D. Brook and Jesus A. Araujo

    Citation: Particle and Fibre Toxicology 2016 13:26

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  25. Content type: Research

    The increasing use of engineered nanomaterials (ENMs) of varying physical and chemical characteristics poses a great challenge for screening and assessing the potential pathology induced by these materials, ne...

    Authors: Jake Nikota, Andrew Williams, Carole L. Yauk, Håkan Wallin, Ulla Vogel and Sabina Halappanavar

    Citation: Particle and Fibre Toxicology 2016 13:25

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  26. Content type: Short report

    Exposure to diesel exhaust (DE) is known to exacerbate allergic inflammation, including virus-induced eosinophil activation in laboratory animals. We have previously shown that in human volunteers with allergi...

    Authors: Erica A. Pawlak, Terry L. Noah, Haibo Zhou, Claire Chehrazi, Carole Robinette, David Diaz-Sanchez, Loretta Müller and Ilona Jaspers

    Citation: Particle and Fibre Toxicology 2016 13:24

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  27. Content type: Research

    Nano-scaled cerium oxide (nCeO2) is used in a variety of applications, including use as a fuel additive, catalyst, and polishing agent, yet potential adverse health effects associated with nCeO2 exposure remain i...

    Authors: Donna C. Davidson, Raymond Derk, Xiaoqing He, Todd A. Stueckle, Joel Cohen, Sandra V. Pirela, Philip Demokritou, Yon Rojanasakul and Liying Wang

    Citation: Particle and Fibre Toxicology 2016 13:23

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  28. Content type: Research

    Ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) are being developed for several biomedical applications including drug delivery and imaging. However, little is known about their possible adverse ...

    Authors: Abderrahim Nemmar, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Saeed Tariq, Samir Attoub and Badreldin H. Ali

    Citation: Particle and Fibre Toxicology 2016 13:22

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  29. Content type: Research

    Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation in multiple organs, with notable prominence in liver, lungs, and kidneys. However, how AgNPs transport...

    Authors: Hua Guo, Jing Zhang, Mary Boudreau, Jie Meng, Jun-jie Yin, Jian Liu and Haiyan Xu

    Citation: Particle and Fibre Toxicology 2016 13:21

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  30. Content type: Review

    Aerosol generation and characterization are critical components in the assessment of the inhalation hazards of engineered nanomaterials (NMs). An extensive review was conducted on aerosol generation and exposu...

    Authors: William W. Polk, Monita Sharma, Christie M. Sayes, Jon A. Hotchkiss and Amy J. Clippinger

    Citation: Particle and Fibre Toxicology 2016 13:20

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  31. Content type: Research

    Particulate matter has been shown to stimulate the innate immune system and induce acute inflammation. Therefore, while nanotechnology has the potential to provide therapeutic formulations with improved effica...

    Authors: Caroline S. Hughes, Liza M. Colhoun, Baljinder K. Bains, Joanne D. Kilgour, Roberta E. Burden, James F. Burrows, Ed C. Lavelle, Brendan F. Gilmore and Christopher J. Scott

    Citation: Particle and Fibre Toxicology 2016 13:19

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  32. Content type: Research

    Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce. Traditionally, ...

    Authors: Susanne N. Kolle, Ursula G. Sauer, Maria C. Rey Moreno, Wera Teubner, Wendel Wohlleben and Robert Landsiedel

    Citation: Particle and Fibre Toxicology 2016 13:18

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  33. Content type: Research

    Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive contr...

    Authors: Stephen H. Gavett, Carl U. Parkinson, Gabrielle A. Willson, Charles E. Wood, Annie M. Jarabek, Kay C. Roberts, Urmila P. Kodavanti and Darol E. Dodd

    Citation: Particle and Fibre Toxicology 2016 13:17

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  34. Content type: Research

    Carbon nanotube (CNT) is used for various industrial purposes, but exhibits carcinogenic effects in experimental animals. Chronic inflammation in the respiratory system may participate in CNT-induced carcinoge...

    Authors: Yusuke Hiraku, Feiye Guo, Ning Ma, Tatsuhiko Yamada, Shumin Wang, Shosuke Kawanishi and Mariko Murata

    Citation: Particle and Fibre Toxicology 2016 13:16

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  35. Content type: Research

    A diverse class of engineered nanomaterials (ENMs) exhibiting a wide array of physical-chemical properties that are associated with toxicological effects in experimental animals is in commercial use. However, ...

    Authors: Sarah Labib, Andrew Williams, Carole L. Yauk, Jake K. Nikota, Håkan Wallin, Ulla Vogel and Sabina Halappanavar

    Citation: Particle and Fibre Toxicology 2016 13:15

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  36. Content type: Research

    Functionalization is believed to have a considerable impact on the biodistribution of fullerene in vivo. However, a direct comparison of differently functionalized fullerenes is required to prove the hypothesi...

    Authors: Chenglong Wang, Yitong Bai, Hongliang Li, Rong Liao, Jiaxin Li, Han Zhang, Xian Zhang, Sujuan Zhang, Sheng-Tao Yang and Xue-Ling Chang

    Citation: Particle and Fibre Toxicology 2016 13:14

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    The Erratum to this article has been published in Particle and Fibre Toxicology 2016 13:43

  37. Content type: Research

    Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) ...

    Authors: Rodosthenis S. Rodosthenous, Brent A. Coull, Quan Lu, Pantel S. Vokonas, Joel D. Schwartz and Andrea A. Baccarelli

    Citation: Particle and Fibre Toxicology 2016 13:13

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  38. Content type: Research

    Silver nanoparticles (AgNPs) are an important class of nanomaterials used as antimicrobial agents for a wide range of medical and industrial applications. However toxicity of AgNPs and impact of their physicoc...

    Authors: Camilla Recordati, Marcella De Maglie, Silvia Bianchessi, Simona Argentiere, Claudia Cella, Silvana Mattiello, Francesco Cubadda, Federica Aureli, Marilena D’Amato, Andrea Raggi, Cristina Lenardi, Paolo Milani and Eugenio Scanziani

    Citation: Particle and Fibre Toxicology 2016 13:12

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  39. Content type: Review

    Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, ...

    Authors: Giulia Vietti, Dominique Lison and Sybille van den Brule

    Citation: Particle and Fibre Toxicology 2016 13:11

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  40. Content type: Research

    Particulate matter (PM) is one of the six criteria pollutant classes for which National Ambient Air Quality Standards have been set by the United States Environmental Protection Agency. Exposures to PM have be...

    Authors: A. Noël, R. Xiao, Z. Perveen, H. M. Zaman, R. L. Rouse, D. B. Paulsen and A. L. Penn

    Citation: Particle and Fibre Toxicology 2016 13:10

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  41. Content type: Research

    The increased incorporation of silver nanoparticles (Ag NPs) into consumer products makes the characterization of potential risk for humans and other organisms essential. The oral route is an important uptake ...

    Authors: Anastasia Georgantzopoulou, Tommaso Serchi, Sébastien Cambier, Céline C. Leclercq, Jenny Renaut, Jia Shao, Marcin Kruszewski, Esther Lentzen, Patrick Grysan, Santhana Eswara, Jean-Nicolas Audinot, Servane Contal, Johanna Ziebel, Cédric Guignard, Lucien Hoffmann, AlberTinka J. Murk…

    Citation: Particle and Fibre Toxicology 2016 13:9

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  42. Content type: Research

    Heart rate and cardiovascular function are regulated by the autonomic nervous system. Heart rate variability (HRV) as a marker reflects the activity of autonomic nervous system. The prognostic significance of ...

    Authors: W. Zheng, W. McKinney, M. Kashon, R. Salmen, V. Castranova and H. Kan

    Citation: Particle and Fibre Toxicology 2016 13:8

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  43. Content type: Research

    The potential human health risks from graphene inhalation exposure have attracted substantial scientific interest as a result of the numerous exciting potential commercial applications of graphene. However, th...

    Authors: Liang Mao, Maojie Hu, Bingcai Pan, Yongchao Xie and Elijah J. Petersen

    Citation: Particle and Fibre Toxicology 2016 13:7

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  44. Content type: Research

    Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet activation in response to pulmonary and systemic in...

    Authors: Caroline M. Tabor, Catherine A. Shaw, Sarah Robertson, Mark R. Miller, Rodger Duffin, Ken Donaldson, David E. Newby and Patrick W. F. Hadoke

    Citation: Particle and Fibre Toxicology 2016 13:6

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  45. Content type: Research

    Poorly soluble cobalt (II, III) oxide particles (Co3O4P) are believed to induce in vitro cytotoxic effects via a Trojan-horse mechanism. Once internalized into lysosomal and acidic intracellular compartments, Co3

    Authors: Chiara Uboldi, Thierry Orsière, Carine Darolles, Valérie Aloin, Virginie Tassistro, Isabelle George and Véronique Malard

    Citation: Particle and Fibre Toxicology 2016 13:5

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  46. Content type: Research

    Due to the wide application of engineered aluminum oxide nanoparticles and increased aluminum containing particulate matter suspending in air, exposure of human to nano-scale aluminum oxide nanoparticles (Al2O3 N...

    Authors: Xiaobo Li, Chengcheng Zhang, Xin Zhang, Shizhi Wang, Qingtao Meng, Shenshen Wu, Hongbao Yang, Yankai Xia and Rui Chen

    Citation: Particle and Fibre Toxicology 2016 13:4

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  47. Content type: Research

    Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule ‘corona’. Hence, the ‘corona’ defines the biological identity of...

    Authors: Isabella Radauer-Preiml, Ancuela Andosch, Thomas Hawranek, Ursula Luetz-Meindl, Markus Wiederstein, Jutta Horejs-Hoeck, Martin Himly, Matthew Boyles and Albert Duschl

    Citation: Particle and Fibre Toxicology 2016 13:3

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