Articles

Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats

Exposure to ambient PM_2.5 increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to ...

Authors: Zhekang Ying, Xiaoyun Xie, Yuntao Bai, Minjie Chen, Xiaoke Wang, Xuan Zhang, Masako Morishita, Qinghua Sun and Sanjay Rajagopalan

Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice

Exposure to PM_2.5 (particulate matter <2.5 μm) has been associated with changes in endothelial function. PM_2.5 was collected from two Chinese cities, Jinchang (JC) and Zhangye (ZH), both with similar PM_2.5 concen...

Authors: Azita K Cuevas, Jingping Niu, Mianhua Zhong, Eric N Liberda, Andrew Ghio, Qingshan Qu and Lung Chi Chen

Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles

Although the surface area metric has been proposed as a possible dose-metric for nanoparticles (NPs), it is limited to low-solubility NPs and the dose-metric for high-solubility NPs is poorly understood. In th...

Authors: Jiyoung Jeong, Youngju Han, Craig A. Poland and Wan-Seob Cho

Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats

The potential for seasonal differences in the physicochemical characteristics of ambient particulate matter (PM) to modify interactive effects with gaseous pollutants has not been thoroughly examined. The purp...

Authors: Aimen K Farraj, Leon Walsh, Najwa Haykal-Coates, Fatiha Malik, John McGee, Darrell Winsett, Rachelle Duvall, Kasey Kovalcik, Wayne E Cascio, Mark Higuchi and Mehdi S Hazari

Dissolution and biodurability: Important parameters needed for risk assessment of nanomaterials

Biopersistence and biodurability have the potential to influence the long-term toxicity and hence pathogenicity of particles that deposit in the body. Therefore, biopersistence and biodurability are considered...

Authors: Wells Utembe, Kariska Potgieter, Aleksandr Byron Stefaniak and Mary Gulumian

Lung particle overload: old school –new insights?

Authors: Paul Borm, Flemming R Cassee and Günter Oberdörster

Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans

We analyze the scientific basis and methodology used by the German MAK Commission in their recommendations for exposure limits and carcinogen classification of “granular biopersistent particles without known s...

Authors: Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J Muranko, Ross Myerson and Robert J McCunney

Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes

The health effects of short-term exposure to ambient ultrafine particles in micro-environments are still under investigation.

Authors: Annette Peters, Regina Hampel, Josef Cyrys, Susanne Breitner, Uta Geruschkat, Ute Kraus, Wojciech Zareba and Alexandra Schneider

Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China

Particles in smaller size fractions, such as ultrafine particles (UFPs) (with diameter less than 100 nm), has become of significant cardiovascular health concerns. However, the biological plausibility underlyi...

Authors: Yitong Sun, Xiaoming Song, Yiqun Han, Yunfang Ji, Shuna Gao, Yu Shang, Shou-en Lu, Tong Zhu and Wei Huang

Oral absorption of PEG-coated versus uncoated gold nanospheres: does agglomeration matter?

Particle size is thought to be a critical factor affecting the bioavailability of nanoparticles following oral exposure. Nearly all studies of nanoparticle bioavailability focus on characterization of the prim...

Authors: Georgia K Hinkley, Paul Carpinone, John W Munson, Kevin W Powers and Stephen M Roberts

Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults

Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects...

Authors: Jette G Hemmingsen, Jenny Rissler, Jens Lykkesfeldt, Gerd Sallsten, Jesper Kristiansen, Peter Møller P and Steffen Loft

Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles

The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to sup...

Authors: Senlin Lu, Wenchao Zhang, Rui Zhang, Pinwei Liu, Qiangxiang Wang, Yu Shang, Minghong Wu, Ken Donaldson and Qingyue Wang

Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice

Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases....

Authors: Yang Sun, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo…

Nanodiamonds act as Trojan horse for intracellular delivery of metal ions to trigger cytotoxicity

Nanomaterials hold great promise for applications in the delivery of various molecules with poor cell penetration, yet its potential for delivery of metal ions is rarely considered. Particularly, there is limi...

Authors: Ying Zhu, Yu Zhang, Guosheng Shi, Jinrong Yang, Jichao Zhang, Wenxin Li, Aiguo Li, Renzhong Tai, Haiping Fang, Chunhai Fan and Qing Huang

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

The lung epithelium constitutes the first barrier against invading pathogens and also a major surface potentially exposed to nanoparticles. In order to ensure and preserve lung epithelial barrier function, the...

Authors: Mathilde Delaval, Sonja Boland, Brigitte Solhonne, Marie-Anne Nicola, Stéphane Mornet, Armelle Baeza-Squiban, Jean-Michel Sallenave and Ignacio Garcia-Verdugo

In vitro investigation of silica nanoparticle uptake into human endothelial cells under physiological cyclic stretch

In general the prediction of the toxicity and therapeutic efficacy of engineered nanoparticles in humans is initially determined using in vitro static cell culture assays. However, such test systems may not be su...

Authors: Christian Freese, Daniel Schreiner, Laura Anspach, Christoph Bantz, Michael Maskos, Ronald E Unger and C James Kirkpatrick

Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Convincing evidence suggests that poorly soluble low-toxicity particles (PSP) exert two unifying major modes of action (MoA), in which one appears to be deposition-related acute, whilst the other is retention-...

Authors: Jürgen Pauluhn

Why does the hemolytic activity of silica predict its pro-inflammatory activity?

The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red b...

Authors: Cristina Pavan, Virginie Rabolli, Maura Tomatis, Bice Fubini and Dominique Lison

Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers

Although major concerns exist regarding the potential consequences of human exposures to nanoscale carbon black (CB) particles, limited human toxicological data is currently available. The purpose of this stud...

Authors: Rong Zhang, Yufei Dai, Xiao Zhang, Yong Niu, Tao Meng, Yuanyuan Li, Huawei Duan, Ping Bin, Meng Ye, Xiaowei Jia, Meili Shen, Shanfa Yu, Xiaofa Yang, Weimin Gao and Yuxin Zheng

Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells

Airborne exposure to nanomaterials from unintended occupational or environmental exposures or as a consequence of product use may lead to adverse health effects. Numerous studies have focused on single-walled ...

Authors: Pallab Sanpui, Xiao Zheng, Julia C Loeb, Joseph H Bisesi Jr, Iftheker A Khan, A R M Nabiul Afrooz, Keira Liu, Appala Raju Badireddy, Mark R Wiesner, P Lee Ferguson, Navid B Saleh, John A Lednicky and Tara Sabo-Attwood

Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats

Ge-imogolites are short aluminogermanate tubular nanomaterials with attractive prospected industrial applications. In view of their nano-scale dimensions and high aspect ratio, they should be examined for thei...

Authors: Sybille van den Brule, Emilie Beckers, Perrine Chaurand, Wei Liu, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Francine Uwambayinema, Yousof Yakoub, Astrid Avellan, Clément Levard, Vincent Haufroid, Etienne Marbaix, Antoine Thill, Dominique Lison and Jérôme Rose

Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function

Diesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area of intensive investigations. With respect to the immune system, DEP have attracted sign...

Authors: Marina Pierdominici, Angela Maselli, Serena Cecchetti, Antonella Tinari, Arianna Mastrofrancesco, Michela Alfè, Valentina Gargiulo, Carlo Beatrice, Gabriele Di Blasio, Giulia Carpinelli, Elena Ortona, Antonello Giovannetti and Silvana Fiorito

The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

Inflammasome-activated IL-1β plays a major role in lung neutrophilic inflammation induced by inhaled silica. However, the exact mechanisms that contribute to the initial production of precursor IL-1β (pro-IL-1...

Authors: Virginie Rabolli, Anissa Alami Badissi, Raynal Devosse, Francine Uwambayinema, Yousof Yakoub, Mihaly Palmai-Pallag, Astrid Lebrun, Valentin De Gussem, Isabelle Couillin, Bernard Ryffel, Etienne Marbaix, Dominique Lison and François Huaux

Exposure to traffic-related air pollution during physical activity and acute changes in blood pressure, autonomic and micro-vascular function in women: a cross-over study

Traffic-related air pollution may contribute to cardiovascular morbidity. In urban areas, exposures during physical activity are of interest owing to increased breathing rates and close proximity to vehicle em...

Authors: Scott Weichenthal, Marianne Hatzopoulou and Mark S Goldberg

Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue

In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has r...

Authors: Monia Savi, Stefano Rossi, Leonardo Bocchi, Laura Gennaccaro, Francesca Cacciani, Alessio Perotti, Davide Amidani, Rossella Alinovi, Matteo Goldoni, Irene Aliatis, Pier Paolo Lottici, Danilo Bersani, Marco Campanini, Silvana Pinelli, Marta Petyx, Caterina Frati…

Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters

Myocardial infarction is the leading cause of death in fire fighters and has been linked with exposure to air pollution and fire suppression duties. We therefore investigated the effects of wood smoke exposure...

Authors: Amanda L Hunter, Jon Unosson, Jenny A Bosson, Jeremy P Langrish, Jamshid Pourazar, Jennifer B Raftis, Mark R Miller, Andrew J Lucking, Christoffer Boman, Robin Nyström, Kenneth Donaldson, Andrew D Flapan, Anoop SV Shah, Louis Pung, Ioannis Sadiktsis, Silvia Masala…

Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics

Changes in DNA methylation have been associated with traffic-related air pollution in observational studies, but the specific mechanisms and temporal dynamics therein have not been explored in a controlled stu...

Authors: Ruiwei Jiang, Meaghan J Jones, Francesco Sava, Michael S Kobor and Christopher Carlsten

Is the toxic potential of nanosilver dependent on its size?

Nanosilver is one of the most commonly used engineered nanomaterials (ENMs). In our study we focused on assessing the size-dependence of the toxicity of nanosilver (Ag ENMs), utilising materials of three sizes...

Authors: Anna Huk, Emilia Izak-Nau, Bogumila Reidy, Matthew Boyles, Albert Duschl, Iseult Lynch and Maria Dušinska

Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum

The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising ...

Authors: Nirmal K Banda, Gaurav Mehta, Ying Chao, Guankui Wang, Swetha Inturi, Liliane Fossati-Jimack, Marina Botto, LinPing Wu, Seyed Moein Moghimi and Dmitri Simberg

Role of microbial and chemical composition in toxicological properties of indoor and outdoor air particulate matter

Ambient air particulate matter (PM) is increasingly considered to be a causal factor evoking severe adverse health effects. People spend the majority of their time indoors, which should be taken into account e...

Authors: Mikko S Happo, Olli Sippula, Pasi I Jalava, Helena Rintala, Ari Leskinen, Mika Komppula, Kari Kuuspalo, Santtu Mikkonen, Kari Lehtinen, Jorma Jokiniemi and Maija-Riitta Hirvonen

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats

Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studi...

Authors: Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory ...

Authors: Paul M Peeters, Irene M J Eurlings, Timothy N Perkins, Emiel F Wouters, Roel P F Schins, Paul J A Borm, Wolfgang Drommer, Niki L Reynaert and Catrin Albrecht

Pulmonary and hemostatic toxicity of multi-walled carbon nanotubes and zinc oxide nanoparticles after pulmonary exposure in Bmal1 knockout mice

Pulmonary exposure to nanoparticles (NPs) may affect, in addition to pulmonary toxicity, the cardiovascular system such as procoagulant effects, vascular dysfunction and progression of atherosclerosis. However...

Authors: Katrien Luyts, Stijn Smulders, Dorota Napierska, Soetkin Van kerckhoven, Katrien Poels, Hans Scheers, Bianca Hemmeryckx, Ben Nemery, Marc F Hoylaerts and Peter H M Hoet

A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability

For many individuals, daily commuting activities on roadways account for a substantial proportion of total exposure, as well as peak-level exposures, to traffic-related air pollutants (TRAPS) including ultrafi...

Authors: Robert J Laumbach, Howard M Kipen, Susan Ko, Kathie Kelly-McNeil, Clarimel Cepeda, Ashley Pettit, Pamela Ohman-Strickland, Lin Zhang, Junfeng Zhang, Jicheng Gong, Manoj Veleeparambil and Andrew J Gow

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter, PM_2.5) and development of insulin resistance/Type II diabetes mellitu...

Authors: Cuiqing Liu, Laura K Fonken, Aixia Wang, Andrei Maiseyeu, Yuntao Bai, Tse-Yao Wang, Santosh Maurya, Yi-An Ko, Muthu Periasamy, Timothy Dvonch, Masako Morishita, Robert D Brook, Jack Harkema, Zhekang Ying, Bhramar Mukherjee, Qinghua Sun…

Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection

Exposures to elevated levels of particulate matter (PM) enhance severity of influenza virus infection in infants. The biological mechanism responsible for this phenomenon is unknown. The recent identification ...

Authors: Greg I Lee, Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, Valerie Y Hebert, Tammy R Dugas and Stephania A Cormier

Biokinetics and effects of barium sulfate nanoparticles

Nanoparticulate barium sulfate has potential novel applications and wide use in the polymer and paint industries. A short-term inhalation study on barium sulfate nanoparticles (BaSO₄ NPs) was previously published...

Authors: Nagarjun Konduru, Jana Keller, Lan Ma-Hock, Sibylle Gröters, Robert Landsiedel, Thomas C Donaghey, Joseph D Brain, Wendel Wohlleben and Ramon M Molina

Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

The liver has a crucial role in metabolic homeostasis as well as being the principal detoxification centre of the body, removing xenobiotics and waste products which could potentially include some nanomaterial...

Authors: Ali Kermanizadeh, Mille L hr, Martin Roursgaard, Simon Messner, Patrina Gunness, Jens M Kelm, Peter Møller, Vicki Stone and Steffen Loft

Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: concordance of electrocardiogram and mechanical responses

Studies have shown a relationship between air pollution and increased risk of cardiovascular morbidity and mortality. Due to the complexity of ambient air pollution composition, recent studies have examined th...

Authors: Nicole Kurhanewicz, Rachel McIntosh-Kastrinsky, Haiyan Tong, Leon Walsh, Aimen K Farraj and Mehdi S Hazari

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

Carbon nanotubes (CNT) represent a great promise for technological and industrial development but serious concerns on their health effects have also emerged. Rod-shaped CNT are, in fact, able to induce asbesto...

Authors: Elina M Rydman, Marit Ilves, Antti J Koivisto, Pia A S Kinaret, Vittorio Fortino, Terhi S Savinko, Maili T Lehto, Ville Pulkkinen, Minnamari Vippola, Kaarle J Hämeri, Sampsa Matikainen, Henrik Wolff, Kai M Savolainen, Dario Greco and Harri Alenius

Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation

Silver nanowires (Ag NWs) are increasingly being used to produce touchscreens for smart phones and computers. When applied in a thin film over a plastic substrate, Ag NWs create a transparent, highly-conductiv...

Authors: Rona M Silva, Jingyi Xu, Clare Saiki, Donald S Anderson, Lisa M Franzi, Chris D Vulpe, Benjamin Gilbert, Laura S Van Winkle and Kent E Pinkerton

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study

Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respi...

Authors: Andrea A Baccarelli, Yinan Zheng, Xiao Zhang, Dou Chang, Lei Liu, Katherine Rose Wolf, Zhou Zhang, John P McCracken, Anaité Díaz, Pier Alberto Bertazzi, Joel Schwartz, Sheng Wang, Choong-Min Kang, Petros Koutrakis and Lifang Hou

Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Toxicity testing the rapidly growing number of nanomaterials requires large scale use of in vitro systems under the presumption that these systems are sufficiently predictive or descriptive of responses in in ...

Authors: Justin G Teeguarden, Vladimir B Mikheev, Kevin R Minard, William C Forsythe, Wei Wang, Gaurav Sharma, Norman Karin, Susan C Tilton, Katrina M Waters, Bahman Asgharian, Owen R Price, Joel G Pounds and Brian D Thrall

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

Given that the effects of ultrafine fractions (<0.1 μm) on ischemic heart diseases (IHD) and other cardiovascular diseases are gaining attention, this study is aimed to explore the influence of silica nanopart...

Authors: Junchao Duan, Yongbo Yu, Yang Yu, Yang Li, Peili Huang, Xianqing Zhou, Shuangqing Peng and Zhiwei Sun

An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles

The challenge remains to reliably mimic human exposure to high aspect ratio nanoparticles (HARN) via inhalation. Sophisticated, multi-cellular in vitro models are a particular advantageous solution to this issue,...

Authors: Carola Endes, Otmar Schmid, Calum Kinnear, Silvana Mueller, Sandra Camarero-Espinosa, Dimitri Vanhecke, E Johan Foster, Alke Petri-Fink, Barbara Rothen-Rutishauser, Christoph Weder and Martin JD Clift

Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles

Although silver nanoparticles are currently used in more than 400 consumer products, it is not clear to what extent they induce adverse effects after inhalation during production and use. In this study, we det...

Authors: Hedwig M Braakhuis, Ilse Gosens, Petra Krystek, John AF Boere, Flemming R Cassee, Paul HB Fokkens, Jan Andries Post, Henk van Loveren and Margriet VDZ Park

Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats

Studies provide compelling evidences for particulate matter (PM) associated cardiovascular health effects. Elderly individuals, particularly those with preexisting conditions like hypertension are regarded to ...

Authors: Swapna Upadhyay, Tobias Stoeger, Leema George, Mette C Schladweiler, Urmila Kodavanti, Koustav Ganguly and Holger Schulz

RETRACTED ARTICLE: Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice

Due to the increased application of titanium dioxide nanoparticles (TiO₂ NPs) in the food industry and daily life, their potential toxic effects in humans and animals h...

Authors: Xiaoyang Zhao, Lei Sheng, Ling Wang, Jie Hong, Xiaohong Yu, Xuezi Sang, Qingqing Sun, Yuguan Ze and Fashui Hong

Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study

Epidemiological and experimental studies suggest that exposure to ultrafine particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics.

Authors: Frank Schaumann, Cornelia Frömke, Dorothea Dijkstra, Francesca Alessandrini, Horst Windt, Erwin Karg, Meike Müller, Carla Winkler, Armin Braun, Armin Koch, Jens Michael Hohlfeld, Heidrun Behrendt, Otmar Schmid, Wolfgang Koch, Holger Schulz and Norbert Krug

Size dependent translocation and fetal accumulation of gold nanoparticles from maternal blood in the rat

There is evidence that nanoparticles (NP) cross epithelial and endothelial body barriers. We hypothesized that gold (Au) NP, once in the blood circulation of pregnant rats, will cross the placental barrier dur...

Authors: Manuela Semmler-Behnke, Jens Lipka, Alexander Wenk, Stephanie Hirn, Martin Schäffler, Furong Tian, Günter Schmid, Günter Oberdörster and Wolfgang G Kreyling