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  1. Content type: Research

    The potential human health risks from graphene inhalation exposure have attracted substantial scientific interest as a result of the numerous exciting potential commercial applications of graphene. However, th...

    Authors: Liang Mao, Maojie Hu, Bingcai Pan, Yongchao Xie and Elijah J. Petersen

    Citation: Particle and Fibre Toxicology 2016 13:7

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  2. Content type: Research

    Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet activation in response to pulmonary and systemic in...

    Authors: Caroline M. Tabor, Catherine A. Shaw, Sarah Robertson, Mark R. Miller, Rodger Duffin, Ken Donaldson, David E. Newby and Patrick W. F. Hadoke

    Citation: Particle and Fibre Toxicology 2016 13:6

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  3. Content type: Research

    Poorly soluble cobalt (II, III) oxide particles (Co3O4P) are believed to induce in vitro cytotoxic effects via a Trojan-horse mechanism. Once internalized into lysosomal and acidic intracellular compartments, Co3

    Authors: Chiara Uboldi, Thierry Orsière, Carine Darolles, Valérie Aloin, Virginie Tassistro, Isabelle George and Véronique Malard

    Citation: Particle and Fibre Toxicology 2016 13:5

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  4. Content type: Research

    Due to the wide application of engineered aluminum oxide nanoparticles and increased aluminum containing particulate matter suspending in air, exposure of human to nano-scale aluminum oxide nanoparticles (Al2O3 N...

    Authors: Xiaobo Li, Chengcheng Zhang, Xin Zhang, Shizhi Wang, Qingtao Meng, Shenshen Wu, Hongbao Yang, Yankai Xia and Rui Chen

    Citation: Particle and Fibre Toxicology 2016 13:4

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  5. Content type: Research

    Engineered nanomaterials (ENMs) interact with different biomolecules as soon as they are in contact, resulting in the formation of a biomolecule ‘corona’. Hence, the ‘corona’ defines the biological identity of...

    Authors: Isabella Radauer-Preiml, Ancuela Andosch, Thomas Hawranek, Ursula Luetz-Meindl, Markus Wiederstein, Jutta Horejs-Hoeck, Martin Himly, Matthew Boyles and Albert Duschl

    Citation: Particle and Fibre Toxicology 2016 13:3

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  6. Content type: Research

    Allergen exposure and air pollution are two risk factors for asthma development and airway inflammation that have been examined extensively in isolation. The impact of combined allergen and diesel exhaust expo...

    Authors: Ali Hosseini, Jeremy A. Hirota, Tillie L. Hackett, Kelly M. McNagny, Susan J. Wilson and Chris Carlsten

    Citation: Particle and Fibre Toxicology 2016 13:2

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  7. Content type: Letter to the Editor

    Citation: Particle and Fibre Toxicology 2016 13:1

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  8. Content type: Research

    Oxidative stress, a commonly used paradigm to explain nanoparticle (NP)-induced toxicity, results from an imbalance between reactive oxygen species (ROS) generation and detoxification. As one consequence, prot...

    Authors: Marc D. Driessen, Sarah Mues, Antje Vennemann, Bryan Hellack, Anne Bannuscher, Vishalini Vimalakanthan, Christian Riebeling, Rainer Ossig, Martin Wiemann, Jürgen Schnekenburger, Thomas A. J. Kuhlbusch, Bernhard Renard, Andreas Luch and Andrea Haase

    Citation: Particle and Fibre Toxicology 2015 12:36

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  9. Content type: Review

    The inhalation of airborne particles can lead to pathological changes in the respiratory tract. For this reason, toxicology studies on effects of inhalable particles and fibers often include an assessment of h...

    Authors: Christina Brandenberger, Matthias Ochs and Christian Mühlfeld

    Citation: Particle and Fibre Toxicology 2015 12:35

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  10. Content type: Commentary

    Although mass emissions of combustion-generated particulate matter have been substantially reduced by new combustion technology, there is still a great concern about the emissions of huge numbers of sub-10 nm ...

    Authors: Paola Pedata, Tobias Stoeger, Ralf Zimmermann, Annette Peters, Günter Oberdörster and Andrea D’Anna

    Citation: Particle and Fibre Toxicology 2015 12:34

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  11. Content type: Research

    Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this study was to determine whether exposure to wood smoke...

    Authors: Ala Muala, Gregory Rankin, Maria Sehlstedt, Jon Unosson, Jenny A. Bosson, Annelie Behndig, Jamshid Pourazar, Robin Nyström, Esbjörn Pettersson, Christoffer Bergvall, Roger Westerholm, Pasi I. Jalava, Mikko S. Happo, Oskari Uski, Maija-Riitta Hirvonen, Frank J. Kelly…

    Citation: Particle and Fibre Toxicology 2015 12:33

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  12. Content type: Research

    Accurate and meaningful dose metrics are a basic requirement for in vitro screening to assess potential health risks of engineered nanomaterials (ENMs). Correctly and consistently quantifying what cells “see,” du...

    Authors: Glen M. DeLoid, Joel M. Cohen, Georgios Pyrgiotakis, Sandra V. Pirela, Anoop Pal, Jiying Liu, Jelena Srebric and Philip Demokritou

    Citation: Particle and Fibre Toxicology 2015 12:32

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  13. Content type: Research

    The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.

    Authors: Nagarjun V. Konduru, Renato J. Jimenez, Archana Swami, Sherri Friend, Vincent Castranova, Philip Demokritou, Joseph D. Brain and Ramon M. Molina

    Citation: Particle and Fibre Toxicology 2015 12:31

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    The Erratum to this article has been published in Particle and Fibre Toxicology 2016 13:35

  14. Content type: Research

    Increasing numbers of individuals may be exposed to nanomaterials during pregnancy. The overarching goal of this investigation was to determine if prenatal inhalation exposure to copper nanoparticles (Cu NPs) ...

    Authors: Andrea Adamcakova-Dodd, Martha M. Monick, Linda S. Powers, Katherine N. Gibson-Corley and Peter S. Thorne

    Citation: Particle and Fibre Toxicology 2015 12:30

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  15. Content type: Research

    Stably transfected lung epithelial reporter cell lines pose an advantageous alternative to replace complex experimental techniques to monitor the pro-inflammatory response following nanoparticle (NP) exposure....

    Authors: Linda C. Stoehr, Carola Endes, Isabella Radauer-Preiml, Matthew S. P. Boyles, Eudald Casals, Sandor Balog, Markus Pesch, Alke Petri-Fink, Barbara Rothen-Rutishauser, Martin Himly, Martin J. D. Clift and Albert Duschl

    Citation: Particle and Fibre Toxicology 2015 12:29

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  16. Content type: Research

    While exposure to ambient air contaminants is clearly associated with adverse health outcomes, disentangling mechanisms of pollutant interactions remains a challenge.

    Authors: Prem Kumarathasan, Erica Blais, Anushuyadevi Saravanamuthu, Agnieszka Bielecki, Ballari Mukherjee, Stephen Bjarnason, Josée Guénette, Patrick Goegan and Renaud Vincent

    Citation: Particle and Fibre Toxicology 2015 12:28

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  17. Content type: Research

    Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO2 NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brai...

    Authors: Clémence Disdier, Jérôme Devoy, Anne Cosnefroy, Monique Chalansonnet, Nathalie Herlin-Boime, Emilie Brun, Amie Lund and Aloïse Mabondzo

    Citation: Particle and Fibre Toxicology 2015 12:27

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  18. Content type: Short report

    Exposure to persistent engineered nano and micro particles via the oral route is well established. Animal studies have demonstrated that, once ingested, a small proportion of such particles translocate from th...

    Authors: Laetitia C. Pele, Vinay Thoree, Sylvaine FA Bruggraber, Dagmar Koller, Richard PH Thompson, Miranda C. Lomer and Jonathan J. Powell

    Citation: Particle and Fibre Toxicology 2015 12:26

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  19. Content type: Research

    The main goal of this research was to study the interactions of a fully characterized set of silver nanomaterials (Ag ENMs) with cells in vitro, according to the standards of Good Laboratory Practices (GLP), to a...

    Authors: Anna Huk, Emilia Izak-Nau, Naouale el Yamani, Hilde Uggerud, Marit Vadset, Beata Zasonska, Albert Duschl and Maria Dusinska

    Citation: Particle and Fibre Toxicology 2015 12:25

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  20. Content type: Research

    Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (s...

    Authors: Errol M. Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Jean-Pierre Charland, Ewa Dabek-Zlotorzynska, Valbona Celo, Prem Kumarathasan, Jeffrey R. Brook and Renaud Vincent

    Citation: Particle and Fibre Toxicology 2015 12:24

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  21. Content type: Retraction Note

    Authors: Suxin Gui, Xuezi Sang, Lei Zheng, Yuguan Ze, Xiaoyang Zhao, Lei Sheng, Qingqing Sun, Zhe Cheng, Jie Cheng, Renping Hu, Ling Wang, Fashui Hong and Meng Tang

    Citation: Particle and Fibre Toxicology 2015 12:22

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    The original article was published in Particle and Fibre Toxicology 2013 10:4

  22. Content type: Research

    Graphistrength © C100 multiwalled carbon nanotubes (MWCNT) provide superior electrical and mechanical properties for various applications. The evaluation of the intrinsic ha...

    Authors: Daniela Pothmann, Sophie Simar, Detlef Schuler, Eva Dony, Stéphane Gaering, Jean-Loïc Le Net, Yoshi Okazaki, Jean Michel Chabagno, Cécile Bessibes, Julien Beausoleil, Fabrice Nesslany and Jean-François Régnier

    Citation: Particle and Fibre Toxicology 2015 12:21

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  23. Content type: Research

    Exposure of the airways to carbonaceous nanoparticles can contribute to the development of immune diseases both via the aggravation of the allergic immune response in sensitized individuals and by adjuvant mec...

    Authors: Matthias Kroker, Ulrich Sydlik, Andrea Autengruber, Christian Cavelius, Heike Weighardt, Annette Kraegeloh and Klaus Unfried

    Citation: Particle and Fibre Toxicology 2015 12:20

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  24. Content type: Research

    Engineered nanoparticles (NP) are being developed for inhaled drug delivery. This route is non-invasive and the major target; alveolar epithelium provides a large surface area for drug administration and absor...

    Authors: Pakatip Ruenraroengsak and Teresa D. Tetley

    Citation: Particle and Fibre Toxicology 2015 12:19

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  25. Content type: Research

    The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health eff...

    Authors: Gerald Bachler, Sabrina Losert, Yuki Umehara, Natalie von Goetz, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Barbara Rothen-Rutishauser and Konrad Hungerbuehler

    Citation: Particle and Fibre Toxicology 2015 12:18

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  26. Content type: Research

    Particulate matter (PM) adverse effects on health include lung and heart damage. The renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) endocrine systems are involved in the pathophysiology of car...

    Authors: Octavio Gamaliel Aztatzi-Aguilar, Marisela Uribe-Ramírez, José Antonio Arias-Montaño, Olivier Barbier and Andrea De Vizcaya-Ruiz

    Citation: Particle and Fibre Toxicology 2015 12:17

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  27. Content type: Research

    The skin is a key route of human exposure to nanomaterials, which typically occurs simultaneously with exposure to other chemical and environmental allergen. However, little is known about the hazards of nanom...

    Authors: Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka…

    Citation: Particle and Fibre Toxicology 2015 12:16

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  28. Content type: Research

    Exposure to ambient PM2.5 increases cardiovascular mortality and morbidity. To delineate the underlying biological mechanism, we investigated the time dependence of cardiovascular response to chronic exposure to ...

    Authors: Zhekang Ying, Xiaoyun Xie, Yuntao Bai, Minjie Chen, Xiaoke Wang, Xuan Zhang, Masako Morishita, Qinghua Sun and Sanjay Rajagopalan

    Citation: Particle and Fibre Toxicology 2015 12:15

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  29. Content type: Research

    Exposure to PM2.5 (particulate matter <2.5 μm) has been associated with changes in endothelial function. PM2.5 was collected from two Chinese cities, Jinchang (JC) and Zhangye (ZH), both with similar PM2.5 concen...

    Authors: Azita K Cuevas, Jingping Niu, Mianhua Zhong, Eric N Liberda, Andrew Ghio, Qingshan Qu and Lung Chi Chen

    Citation: Particle and Fibre Toxicology 2015 12:14

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  30. Content type: Research

    The potential for seasonal differences in the physicochemical characteristics of ambient particulate matter (PM) to modify interactive effects with gaseous pollutants has not been thoroughly examined. The purp...

    Authors: Aimen K Farraj, Leon Walsh, Najwa Haykal-Coates, Fatiha Malik, John McGee, Darrell Winsett, Rachelle Duvall, Kasey Kovalcik, Wayne E Cascio, Mark Higuchi and Mehdi S Hazari

    Citation: Particle and Fibre Toxicology 2015 12:12

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  31. Content type: Review

    Biopersistence and biodurability have the potential to influence the long-term toxicity and hence pathogenicity of particles that deposit in the body. Therefore, biopersistence and biodurability are considered...

    Authors: Wells Utembe, Kariska Potgieter, Aleksandr Byron Stefaniak and Mary Gulumian

    Citation: Particle and Fibre Toxicology 2015 12:11

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  32. Content type: Research

    We analyze the scientific basis and methodology used by the German MAK Commission in their recommendations for exposure limits and carcinogen classification of “granular biopersistent particles without known s...

    Authors: Peter Morfeld, Joachim Bruch, Len Levy, Yufanyi Ngiewih, Ishrat Chaudhuri, Henry J Muranko, Ross Myerson and Robert J McCunney

    Citation: Particle and Fibre Toxicology 2015 12:3

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  33. Content type: Research

    The health effects of short-term exposure to ambient ultrafine particles in micro-environments are still under investigation.

    Authors: Annette Peters, Regina Hampel, Josef Cyrys, Susanne Breitner, Uta Geruschkat, Ute Kraus, Wojciech Zareba and Alexandra Schneider

    Citation: Particle and Fibre Toxicology 2015 12:7

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  34. Content type: Research

    Particle size is thought to be a critical factor affecting the bioavailability of nanoparticles following oral exposure. Nearly all studies of nanoparticle bioavailability focus on characterization of the prim...

    Authors: Georgia K Hinkley, Paul Carpinone, John W Munson, Kevin W Powers and Stephen M Roberts

    Citation: Particle and Fibre Toxicology 2015 12:9

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  35. Content type: Research

    Particles in smaller size fractions, such as ultrafine particles (UFPs) (with diameter less than 100 nm), has become of significant cardiovascular health concerns. However, the biological plausibility underlyi...

    Authors: Yitong Sun, Xiaoming Song, Yiqun Han, Yunfang Ji, Shuna Gao, Yu Shang, Shou-en Lu, Tong Zhu and Wei Huang

    Citation: Particle and Fibre Toxicology 2015 12:8

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  36. Content type: Research

    Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects...

    Authors: Jette G Hemmingsen, Jenny Rissler, Jens Lykkesfeldt, Gerd Sallsten, Jesper Kristiansen, Peter Møller P and Steffen Loft

    Citation: Particle and Fibre Toxicology 2015 12:6

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  37. Content type: Research

    The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to sup...

    Authors: Senlin Lu, Wenchao Zhang, Rui Zhang, Pinwei Liu, Qiangxiang Wang, Yu Shang, Minghong Wu, Ken Donaldson and Qingyue Wang

    Citation: Particle and Fibre Toxicology 2015 12:5

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  38. Content type: Research

    Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases....

    Authors: Yang Sun, Feng Guo, Zhen Zou, Chenggang Li, Xiaoxu Hong, Yan Zhao, Chenxuan Wang, Hongliang Wang, Haolin Liu, Peng Yang, Zongsheng Han, Kangtai Liu, Keiji Kuba, Bin Song, Jinming Gao, Ziyao Mo…

    Citation: Particle and Fibre Toxicology 2015 12:4

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  39. Content type: Research

    Nanomaterials hold great promise for applications in the delivery of various molecules with poor cell penetration, yet its potential for delivery of metal ions is rarely considered. Particularly, there is limi...

    Authors: Ying Zhu, Yu Zhang, Guosheng Shi, Jinrong Yang, Jichao Zhang, Wenxin Li, Aiguo Li, Renzhong Tai, Haiping Fang, Chunhai Fan and Qing Huang

    Citation: Particle and Fibre Toxicology 2015 12:2

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  40. Content type: Research

    The lung epithelium constitutes the first barrier against invading pathogens and also a major surface potentially exposed to nanoparticles. In order to ensure and preserve lung epithelial barrier function, the...

    Authors: Mathilde Delaval, Sonja Boland, Brigitte Solhonne, Marie-Anne Nicola, Stéphane Mornet, Armelle Baeza-Squiban, Jean-Michel Sallenave and Ignacio Garcia-Verdugo

    Citation: Particle and Fibre Toxicology 2015 12:1

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  41. Content type: Research

    In general the prediction of the toxicity and therapeutic efficacy of engineered nanoparticles in humans is initially determined using in vitro static cell culture assays. However, such test systems may not be su...

    Authors: Christian Freese, Daniel Schreiner, Laura Anspach, Christoph Bantz, Michael Maskos, Ronald E Unger and C James Kirkpatrick

    Citation: Particle and Fibre Toxicology 2014 11:68

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  42. Content type: Review

    Convincing evidence suggests that poorly soluble low-toxicity particles (PSP) exert two unifying major modes of action (MoA), in which one appears to be deposition-related acute, whilst the other is retention-...

    Authors: Jürgen Pauluhn

    Citation: Particle and Fibre Toxicology 2014 11:72

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  43. Content type: Research

    The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red b...

    Authors: Cristina Pavan, Virginie Rabolli, Maura Tomatis, Bice Fubini and Dominique Lison

    Citation: Particle and Fibre Toxicology 2014 11:76

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  44. Content type: Research

    Diesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area of intensive investigations. With respect to the immune system, DEP have attracted sign...

    Authors: Marina Pierdominici, Angela Maselli, Serena Cecchetti, Antonella Tinari, Arianna Mastrofrancesco, Michela Alfè, Valentina Gargiulo, Carlo Beatrice, Gabriele Di Blasio, Giulia Carpinelli, Elena Ortona, Antonello Giovannetti and Silvana Fiorito

    Citation: Particle and Fibre Toxicology 2014 11:74

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  45. Content type: Research

    Although major concerns exist regarding the potential consequences of human exposures to nanoscale carbon black (CB) particles, limited human toxicological data is currently available. The purpose of this stud...

    Authors: Rong Zhang, Yufei Dai, Xiao Zhang, Yong Niu, Tao Meng, Yuanyuan Li, Huawei Duan, Ping Bin, Meng Ye, Xiaowei Jia, Meili Shen, Shanfa Yu, Xiaofa Yang, Weimin Gao and Yuxin Zheng

    Citation: Particle and Fibre Toxicology 2014 11:73

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  46. Content type: Research

    Ge-imogolites are short aluminogermanate tubular nanomaterials with attractive prospected industrial applications. In view of their nano-scale dimensions and high aspect ratio, they should be examined for thei...

    Authors: Sybille van den Brule, Emilie Beckers, Perrine Chaurand, Wei Liu, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Francine Uwambayinema, Yousof Yakoub, Astrid Avellan, Clément Levard, Vincent Haufroid, Etienne Marbaix, Antoine Thill, Dominique Lison and Jérôme Rose

    Citation: Particle and Fibre Toxicology 2014 11:67

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  47. Content type: Research

    Airborne exposure to nanomaterials from unintended occupational or environmental exposures or as a consequence of product use may lead to adverse health effects. Numerous studies have focused on single-walled ...

    Authors: Pallab Sanpui, Xiao Zheng, Julia C Loeb, Joseph H Bisesi Jr, Iftheker A Khan, A R M Nabiul Afrooz, Keira Liu, Appala Raju Badireddy, Mark R Wiesner, P Lee Ferguson, Navid B Saleh, John A Lednicky and Tara Sabo-Attwood

    Citation: Particle and Fibre Toxicology 2014 11:66

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