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  1. The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the...

    Authors: Antonio Anax Falcão de Oliveira, Tiago Franco de Oliveira, Michelle Francini Dias, Marisa Helena Gennari Medeiros, Paolo Di Mascio, Mariana Veras, Miriam Lemos, Tania Marcourakis, Paulo Hilário Nascimento Saldiva and Ana Paula Melo Loureiro
    Citation: Particle and Fibre Toxicology 2018 15:40
    Content type: Research Published on:

  2. The extensive biological applications of zinc oxide nanoparticles (ZnO NPs) in stomatology have created serious concerns about their biotoxicity. In our previous study, ZnO NPs were confirmed to transfer to th...

    Authors: Huimin Liang, Aijie Chen, Xuan Lai, Jia Liu, Junrong Wu, Yiyuan Kang, Xinying Wang and Longquan Shao
    Citation: Particle and Fibre Toxicology 2018 15:39
    Content type: Research Published on:

  3. Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction syst...

    Authors: Siqi Zhang, Susanne Breitner, Wayne E Cascio, Robert B Devlin, Lucas M Neas, David Diaz-Sanchez, William E Kraus, Joel Schwartz, Elizabeth R Hauser, Annette Peters and Alexandra Schneider
    Citation: Particle and Fibre Toxicology 2018 15:38
    Content type: Research Published on:

  4. An increasing number of manufactured nanomaterials (NMs) are being used in industrial products and need to be registered under the REACH legislation. The hazard characterisation of all these forms is not only ...

    Authors: L. Lamon, D. Asturiol, A. Richarz, E. Joossens, R. Graepel, K. Aschberger and A. Worth
    Citation: Particle and Fibre Toxicology 2018 15:37
    Content type: Research Published on:

  5. Engineered nanoparticles are smaller than 100 nm and designed to improve or creating even new physico-chemical properties. Consequently, toxicological properties of materials may change as size reaches the nm ...

    Authors: Masakazu Umezawa, Atsuto Onoda, Irina Korshunova, Alexander C. Ø. Jensen, Ismo K. Koponen, Keld A. Jensen, Konstantin Khodosevich, Ulla Vogel and Karin S. Hougaard
    Citation: Particle and Fibre Toxicology 2018 15:36
    Content type: Research Published on:

  6. Exposure to particulate matter (PM) has been associated with increased incidence and severity of autoimmune disease. Diesel PM is primarily composed of an elemental carbon core and adsorbed organic compounds s...

    Authors: Chelsea A. O’Driscoll, Leah A. Owens, Madeline E. Gallo, Erica J. Hoffmann, Amin Afrazi, Mei Han, John H. Fechner, James J. Schauer, Christopher A. Bradfield and Joshua D. Mezrich
    Citation: Particle and Fibre Toxicology 2018 15:35
    Content type: Research Published on:

  7. There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samp...

    Authors: Premkumari Kumarathasan, Renaud Vincent, Erica Blais, Agnieszka Bielecki, Josée Guénette, Alain Filiatreault, Orly Brion, Sabit Cakmak, Errol M. Thomson, Robin Shutt, Lisa Marie Kauri, Mamun Mahmud, Ling Liu and Robert Dales
    Citation: Particle and Fibre Toxicology 2018 15:34
    Content type: Research Published on:

  8. The biological effects of nanoparticles depend on several characteristics such as size and shape that must be taken into account in any type of assessment. The increased use of titanium dioxide nanoparticles (TiO

    Authors: Alba García-Rodríguez, Laura Vila, Constanza Cortés, Alba Hernández and Ricard Marcos
    Citation: Particle and Fibre Toxicology 2018 15:33
    Content type: Research Published on:

  9. Genotoxicity is an important toxicological endpoint due to the link to diseases such as cancer. Therefore, an increased understanding regarding genotoxicity and underlying mechanisms is needed for assessing th...

    Authors: Sebastiano Di Bucchianico, Anda R. Gliga, Emma Åkerlund, Sara Skoglund, Inger Odnevall Wallinder, Bengt Fadeel and Hanna L. Karlsson
    Citation: Particle and Fibre Toxicology 2018 15:32
    Content type: Research Published on:

  10. The well-known inflammatory and fibrogenic changes of the lung upon crystalline silica are accompanied by early changes of the phospholipid composition (PLC) as detected in broncho-alveolar lavage fluid (BALF)...

    Authors: Mandy Großgarten, Matthias Holzlechner, Antje Vennemann, Anna Balbekova, Karin Wieland, Michael Sperling, Bernhard Lendl, Martina Marchetti-Deschmann, Uwe Karst and Martin Wiemann
    Citation: Particle and Fibre Toxicology 2018 15:31
    Content type: Research Published on:

  11. Facemasks are increasingly worn during air pollution episodes in China, but their protective effects are poorly understood. We aimed to evaluate the filtration efficiencies of N95 facemasks and the cardiopulmo...

    Authors: Tianjia Guan, Songhe Hu, Yiqun Han, Ruoyu Wang, Qindan Zhu, Yaoqian Hu, Hanqing Fan and Tong Zhu
    Citation: Particle and Fibre Toxicology 2018 15:30
    Content type: Research Published on:

  12. Engineered nanomaterials (ENM) are used extensively in food products to fulfill a number of roles, including enhancement of color and texture, for nutritional fortification, enhanced bioavailability, improved ...

    Authors: Ikjot Singh Sohal, Kevin S. O’Fallon, Peter Gaines, Philip Demokritou and Dhimiter Bello
    Citation: Particle and Fibre Toxicology 2018 15:29
    Content type: Review Published on:

  13. Silica nanoparticles (SiO2-NPs) are naturally enriched and broadly utilized in the manufacturing industry. While previous studies have demonstrated toxicity in neuronal cell lines after SiO2-NPs exposure, the rol...

    Authors: Ran You, Yuen-Shan Ho, Clara Hiu-Ling Hung, Yan Liu, Chun-Xia Huang, Hei-Nga Chan, See-Lok Ho, Sheung-Yeung Lui, Hung-Wing Li and Raymond Chuen-Chung Chang
    Citation: Particle and Fibre Toxicology 2018 15:28
    Content type: Research Published on:

  14. Cardiovascular disease is the leading cause of mortality in the advanced world, and age is an important determinant of cardiac function. The purpose of the study is to determine whether the PM2.5-induced cardiac ...

    Authors: Guohua Qin, Jin Xia, Yingying Zhang, Lianghong Guo, Rui Chen and Nan Sang
    Citation: Particle and Fibre Toxicology 2018 15:27
    Content type: Research Published on:

  15. Intestinal barrier is crucial for animals against translocation of engineered nanomaterials (ENMs) into secondary targeted organs. However, the molecular mechanisms for the role of intestinal barrier against E...

    Authors: Mingxia Ren, Li Zhao, Xuecheng Ding, Natalia Krasteva, Qi Rui and Dayong Wang
    Citation: Particle and Fibre Toxicology 2018 15:26
    Content type: Research Published on:

  16. Animal models remain at that time a reference tool to predict potential pulmonary adverse effects of nanomaterials in humans. However, in a context of reduction of the number of animals used in experimentation...

    Authors: Thomas Loret, Françoise Rogerieux, Bénédicte Trouiller, Anne Braun, Christophe Egles and Ghislaine Lacroix
    Citation: Particle and Fibre Toxicology 2018 15:25
    Content type: Research Published on:

  17. Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO2NPs) have the ability to modify disease outcome but have not been investigated fo...

    Authors: Kirsty Meldrum, Sarah B. Robertson, Isabella Römer, Tim Marczylo, Lareb S. N. Dean, Andrew Rogers, Timothy W. Gant, Rachel Smith, Terry D. Tetley and Martin O. Leonard
    Citation: Particle and Fibre Toxicology 2018 15:24
    Content type: Research Published on:

  19. Commercial use of carbon nanotubes and nanofibers (CNT/F) in composites and electronics is increasing; however, little is known about health effects among workers. We conducted a cross-sectional study among 10...

    Authors: Mary K. Schubauer-Berigan, Matthew M. Dahm, Aaron Erdely, John D. Beard, M. Eileen Birch, Douglas E. Evans, Joseph E. Fernback, Robert R. Mercer, Stephen J. Bertke, Tracy Eye and Marie A. de Perio
    Citation: Particle and Fibre Toxicology 2018 15:22
    Content type: Research Published on:

  20. Exposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute to endothelial dysfunction and ...

    Authors: Bendik C. Brinchmann, Tonje Skuland, Mia H. Rambøl, Krisztina Szoke, Jan E. Brinchmann, Arno C. Gutleb, Elisa Moschini, Alena Kubátová, Klara Kukowski, Eric Le Ferrec, Dominique Lagadic-Gossmann, Per E. Schwarze, Marit Låg, Magne Refsnes, Johan Øvrevik and Jørn A. Holme
    Citation: Particle and Fibre Toxicology 2018 15:21
    Content type: Research Published on:

  21. Pollutant particles containing environmentally persistent free radicals (EPFRs) are formed during many combustion processes (e.g. thermal remediation of hazardous wastes, diesel/gasoline combustion, wood smoke...

    Authors: Sridhar Jaligama, Vivek S. Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R. Mancuso, Tammy R. Dugas and Stephania A. Cormier
    Citation: Particle and Fibre Toxicology 2018 15:20
    Content type: Research Published on:

  22. Diesel exhaust particles (DEP) are a major component of outdoor air pollution. DEP mediated pulmonary effects are plausibly linked to inflammatory and oxidative stress response in which macrophages (MQ), epith...

    Authors: Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde and Lena Palmberg
    Citation: Particle and Fibre Toxicology 2018 15:19
    Content type: Research Published on:

  24. Exposure to ambient fine particulate matter (PM2.5) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial p...

    Authors: Wanjun Wang, Ji Zhou, Minjie Chen, Xingke Huang, Xiaoyun Xie, Weihua Li, Qi Cao, Haidong Kan, Yanyi Xu and Zhekang Ying
    Citation: Particle and Fibre Toxicology 2018 15:17
    Content type: Research Published on:

  25. The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an impor...

    Authors: Yulai Shen, Lu Wu, Dongdong Qin, Yankai Xia, Zhu Zhou, Xuemei Zhang and Xin Wu
    Citation: Particle and Fibre Toxicology 2018 15:16
    Content type: Research Published on:

  26. Titanium dioxide (TiO2) is produced at high volumes and applied in many consumer and food products. Recent toxicokinetic modelling indicated the potential of TiO2 to accumulate in human liver and spleen upon dail...

    Authors: M. B. Heringa, R. J. B. Peters, R. L. A. W. Bleys, M. K. van der Lee, P. C. Tromp, P. C. E. van Kesteren, J. C. H. van Eijkeren, A. K. Undas, A. G. Oomen and H. Bouwmeester
    Citation: Particle and Fibre Toxicology 2018 15:15
    Content type: Research Published on:

  27. Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by...

    Authors: Yang Bai, Hannelore Bové, Tim S. Nawrot and Benoit Nemery
    Citation: Particle and Fibre Toxicology 2018 15:14
    Content type: Research Published on:

  28. Epidemiological studies have suggested that elevated levels of air pollution contribute to an increased incidence or severity of asthma. Although late-onset adult asthma seems to be more attributable to enviro...

    Authors: Mei Mei, Haojun Song, Lina Chen, Bin Hu, Ru Bai, Diandou Xu, Ying Liu, Yuliang Zhao and Chunying Chen
    Citation: Particle and Fibre Toxicology 2018 15:13
    Content type: Research Published on:

  29. Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of particles via food or indirectly by removal of inhaled material from the airways by ...

    Authors: Ditte Marie Jensen, Daniel Vest Christophersen, Majid Sheykhzade, Gry Freja Skovsted, Jens Lykkesfeldt, Rasmus Münter, Martin Roursgaard, Steffen Loft and Peter Møller
    Citation: Particle and Fibre Toxicology 2018 15:12
    Content type: Research Published on:

  30. Inhalation of high concentrations of zinc oxide particles (ZnO) may cause metal fume fever. In an earlier human inhalation study, no effects were observed after exposure to ZnO concentrations of 0.5 mg/m3. Furthe...

    Authors: Christian Monsé, Olaf Hagemeyer, Monika Raulf, Birger Jettkant, Vera van Kampen, Benjamin Kendzia, Vitali Gering, Günther Kappert, Tobias Weiss, Nadin Ulrich, Eike-Maximilian Marek, Jürgen Bünger, Thomas Brüning and Rolf Merget
    Citation: Particle and Fibre Toxicology 2018 15:8
    Content type: Research Published on:

  31. Epidemiological studies link inhalation of particles to increased risk of cardiovascular disease. Inhaled particles may induce cardiovascular disease by several different mechanisms including translocation of ...

    Authors: Ulla Vogel and Flemming R. Cassee
    Citation: Particle and Fibre Toxicology 2018 15:7
    Content type: Editorial Published on:

  32. Subtle DNA methylation alterations mediated by carbon nanotubes (CNTs) exposure might contribute to pathogenesis and disease susceptibility. It is known that both multi-walled carbon nanotubes (MWCNTs) and sin...

    Authors: Deniz Öner, Manosij Ghosh, Hannelore Bové, Matthieu Moisse, Bram Boeckx, Radu C. Duca, Katrien Poels, Katrien Luyts, Eveline Putzeys, Kirsten Van Landuydt, Jeroen AJ Vanoirbeek, Marcel Ameloot, Diether Lambrechts, Lode Godderis and Peter HM Hoet
    Citation: Particle and Fibre Toxicology 2018 15:11
    Content type: Research Published on:

  33. Semen quality parameters are potentially affected by nanomaterials in several ways: Inhaled nanosized particles are potent inducers of pulmonary inflammation, leading to the release of inflammatory mediators. ...

    Authors: Astrid Skovmand, Anna Jacobsen Lauvås, Preben Christensen, Ulla Vogel, Karin Sørig Hougaard and Sandra Goericke-Pesch
    Citation: Particle and Fibre Toxicology 2018 15:10
    Content type: Research Published on:

  34. The use of engineered nanoparticles (NP) is widespread and still increasing. There is a great need to assess their safety. Newly engineered NP enter the market in a large variety; therefore saf...

    Authors: Rob J. Vandebriel, Jolanda P. Vermeulen, Laurens B. van Engelen, Britt de Jong, Lisa M. Verhagen, Liset J. de la Fonteyne-Blankestijn, Marieke E. Hoonakker and Wim H. de Jong
    Citation: Particle and Fibre Toxicology 2018 15:9
    Content type: Research Published on:

  35. The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard r...

    Authors: Dennis G. Thomas, Jordan N. Smith, Brian D. Thrall, Donald R. Baer, Hadley Jolley, Prabhakaran Munusamy, Vamsi Kodali, Philip Demokritou, Joel Cohen and Justin G. Teeguarden
    Citation: Particle and Fibre Toxicology 2018 15:6
    Content type: Research Published on:

  36. Nanoparticles (NPs) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. Here, we describe the modula...

    Authors: Juan Li, Runhong Lei, Xin Li, Fengxia Xiong, Quanyang Zhang, Yue Zhou, Shengmei Yang, Yanan Chang, Kui Chen, Weihong Gu, Chongming Wu and Gengmei Xing
    Citation: Particle and Fibre Toxicology 2018 15:5
    Content type: Research Published on:

  37. Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of air po...

    Authors: Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang and Yuh-Lien Chen
    Citation: Particle and Fibre Toxicology 2018 15:4
    Content type: Research Published on:

  38. The integration of engineered nanomaterials (ENM) is well-established and widespread in clinical, commercial, and domestic applications. Cardiovascular dysfunctions have been reported in adult populations afte...

    Authors: P. A. Stapleton, Q. A. Hathaway, C. E. Nichols, A. B. Abukabda, M. V. Pinti, D. L. Shepherd, C. R. McBride, J. Yi, V. C. Castranova, J. M. Hollander and T. R. Nurkiewicz
    Citation: Particle and Fibre Toxicology 2018 15:3
    Content type: Research Published on:

  39. Little is known about the mechanism underlying the genotoxicity observed in the liver following pulmonary exposure to carbon black (CB) nanoparticles (NPs). The genotoxicity could be caused by the presence of ...

    Authors: Justyna Modrzynska, Trine Berthing, Gitte Ravn-Haren, Nicklas Raun Jacobsen, Ingrid Konow Weydahl, Katrin Loeschner, Alicja Mortensen, Anne Thoustrup Saber and Ulla Vogel
    Citation: Particle and Fibre Toxicology 2018 15:2
    Content type: Research Published on:

  40. Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several...

    Authors: Sarah Robertson and Mark R. Miller
    Citation: Particle and Fibre Toxicology 2018 15:1
    Content type: Review Published on:

  41. Lead is well known environmental pollutant, which can cause toxic effects in multiple organ systems. However, the influence of lead oxide nanoparticles, frequently emitted to the environment by high temperatur...

    Authors: J. Dumková, T. Smutná, L. Vrlíková, P. Le Coustumer, Z. Večeřa, B. Dočekal, P. Mikuška, L. Čapka, P. Fictum, A. Hampl and M. Buchtová
    Citation: Particle and Fibre Toxicology 2017 14:55
    Content type: Research Published on:

  43. Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced l...

    Authors: Xiaobo Li, Hongbao Yang, Shenshen Wu, Qingtao Meng, Hao Sun, Runze Lu, Jian Cui, Yuxin Zheng, Wen Chen, Rong Zhang, Michael Aschner and Rui Chen
    Citation: Particle and Fibre Toxicology 2017 14:53
    Content type: Research Published on:

  45. Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma−/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. ...

    Authors: Sebastian Riedle, Laetitia C. Pele, Don E. Otter, Rachel E. Hewitt, Harjinder Singh, Nicole C. Roy and Jonathan J. Powell
    Citation: Particle and Fibre Toxicology 2017 14:51
    Content type: Research Published on:

  46. To better assess potential hepatotoxicity of nanomaterials, human liver HepG2 cells were exposed for 3 days to five different CeO2 (either 30 or 100 μg/ml), 3 SiO2 based (30 μg/ml) or 1 CuO (3 μg/ml) nanomaterial...

    Authors: Kirk T. Kitchin, Steve Stirdivant, Brian L. Robinette, Benjamin T. Castellon and Xinhua Liang
    Citation: Particle and Fibre Toxicology 2017 14:50
    Content type: Research Published on:

  47. The lung represents the primary entry route for airborne particles into the human body. Most studies addressed possible adverse effects using single (nano)particles, but aerosolic nanoparticles (NPs) tend to a...

    Authors: Estelle Durantie, Dimitri Vanhecke, Laura Rodriguez-Lorenzo, Flavien Delhaes, Sandor Balog, Dedy Septiadi, Joel Bourquin, Alke Petri-Fink and Barbara Rothen-Rutishauser
    Citation: Particle and Fibre Toxicology 2017 14:49
    Content type: Research Published on:

  48. The toxicokinetics of nanomaterials are an important factor in toxicity, which may be affected by slow clearance and/or distribution in the body.

    Authors: Naohide Shinohara, Guihua Zhang, Yutaka Oshima, Toshio Kobayashi, Nobuya Imatanaka, Makoto Nakai, Takeshi Sasaki, Kenji Kawaguchi and Masashi Gamo
    Citation: Particle and Fibre Toxicology 2017 14:48
    Content type: Research Published on:

  49. There is a fundamental gap of knowledge on the health effects caused by the interaction of engineered nanomaterials (ENM) with the gastro-intestinal tract (GIT). This is partly due to the incomplete knowledge ...

    Authors: Antonio Pietroiusti, Enrico Bergamaschi, Marcello Campagna, Luisa Campagnolo, Giuseppe De Palma, Sergio Iavicoli, Veruscka Leso, Andrea Magrini, Michele Miragoli, Paola Pedata, Leonardo Palombi and Ivo Iavicoli
    Citation: Particle and Fibre Toxicology 2017 14:47
    Content type: Review Published on:

  50. Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse...

    Authors: Cécile Vignal, Muriel Pichavant, Laurent Y. Alleman, Madjid Djouina, Florian Dingreville, Esperanza Perdrix, Christophe Waxin, Adil Ouali Alami, Corinne Gower-Rousseau, Pierre Desreumaux and Mathilde Body-Malapel
    Citation: Particle and Fibre Toxicology 2017 14:46
    Content type: Research Published on:
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