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  1. Genotoxicity is an important toxicological endpoint due to the link to diseases such as cancer. Therefore, an increased understanding regarding genotoxicity and underlying mechanisms is needed for assessing th...

    Authors: Sebastiano Di Bucchianico, Anda R. Gliga, Emma Åkerlund, Sara Skoglund, Inger Odnevall Wallinder, Bengt Fadeel and Hanna L. Karlsson

    Citation: Particle and Fibre Toxicology 2018 15:32

    Content type: Research

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  2. The well-known inflammatory and fibrogenic changes of the lung upon crystalline silica are accompanied by early changes of the phospholipid composition (PLC) as detected in broncho-alveolar lavage fluid (BALF)...

    Authors: Mandy Großgarten, Matthias Holzlechner, Antje Vennemann, Anna Balbekova, Karin Wieland, Michael Sperling, Bernhard Lendl, Martina Marchetti-Deschmann, Uwe Karst and Martin Wiemann

    Citation: Particle and Fibre Toxicology 2018 15:31

    Content type: Research

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  3. Facemasks are increasingly worn during air pollution episodes in China, but their protective effects are poorly understood. We aimed to evaluate the filtration efficiencies of N95 facemasks and the cardiopulmo...

    Authors: Tianjia Guan, Songhe Hu, Yiqun Han, Ruoyu Wang, Qindan Zhu, Yaoqian Hu, Hanqing Fan and Tong Zhu

    Citation: Particle and Fibre Toxicology 2018 15:30

    Content type: Research

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  4. Engineered nanomaterials (ENM) are used extensively in food products to fulfill a number of roles, including enhancement of color and texture, for nutritional fortification, enhanced bioavailability, improved ...

    Authors: Ikjot Singh Sohal, Kevin S. O’Fallon, Peter Gaines, Philip Demokritou and Dhimiter Bello

    Citation: Particle and Fibre Toxicology 2018 15:29

    Content type: Review

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  5. Silica nanoparticles (SiO2-NPs) are naturally enriched and broadly utilized in the manufacturing industry. While previous studies have demonstrated toxicity in neuronal cell lines after SiO2-NPs exposure, the rol...

    Authors: Ran You, Yuen-Shan Ho, Clara Hiu-Ling Hung, Yan Liu, Chun-Xia Huang, Hei-Nga Chan, See-Lok Ho, Sheung-Yeung Lui, Hung-Wing Li and Raymond Chuen-Chung Chang

    Citation: Particle and Fibre Toxicology 2018 15:28

    Content type: Research

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  6. Cardiovascular disease is the leading cause of mortality in the advanced world, and age is an important determinant of cardiac function. The purpose of the study is to determine whether the PM2.5-induced cardiac ...

    Authors: Guohua Qin, Jin Xia, Yingying Zhang, Lianghong Guo, Rui Chen and Nan Sang

    Citation: Particle and Fibre Toxicology 2018 15:27

    Content type: Research

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  7. Intestinal barrier is crucial for animals against translocation of engineered nanomaterials (ENMs) into secondary targeted organs. However, the molecular mechanisms for the role of intestinal barrier against E...

    Authors: Mingxia Ren, Li Zhao, Xuecheng Ding, Natalia Krasteva, Qi Rui and Dayong Wang

    Citation: Particle and Fibre Toxicology 2018 15:26

    Content type: Research

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  8. Animal models remain at that time a reference tool to predict potential pulmonary adverse effects of nanomaterials in humans. However, in a context of reduction of the number of animals used in experimentation...

    Authors: Thomas Loret, Françoise Rogerieux, Bénédicte Trouiller, Anne Braun, Christophe Egles and Ghislaine Lacroix

    Citation: Particle and Fibre Toxicology 2018 15:25

    Content type: Research

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  9. Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO2NPs) have the ability to modify disease outcome but have not been investigated fo...

    Authors: Kirsty Meldrum, Sarah B. Robertson, Isabella Römer, Tim Marczylo, Lareb S. N. Dean, Andrew Rogers, Timothy W. Gant, Rachel Smith, Terry D. Tetley and Martin O. Leonard

    Citation: Particle and Fibre Toxicology 2018 15:24

    Content type: Research

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  10. Commercial use of carbon nanotubes and nanofibers (CNT/F) in composites and electronics is increasing; however, little is known about health effects among workers. We conducted a cross-sectional study among 10...

    Authors: Mary K. Schubauer-Berigan, Matthew M. Dahm, Aaron Erdely, John D. Beard, M. Eileen Birch, Douglas E. Evans, Joseph E. Fernback, Robert R. Mercer, Stephen J. Bertke, Tracy Eye and Marie A. de Perio

    Citation: Particle and Fibre Toxicology 2018 15:22

    Content type: Research

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  11. Exposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute to endothelial dysfunction and ...

    Authors: Bendik C. Brinchmann, Tonje Skuland, Mia H. Rambøl, Krisztina Szoke, Jan E. Brinchmann, Arno C. Gutleb, Elisa Moschini, Alena Kubátová, Klara Kukowski, Eric Le Ferrec, Dominique Lagadic-Gossmann, Per E. Schwarze, Marit Låg, Magne Refsnes, Johan Øvrevik and Jørn A. Holme

    Citation: Particle and Fibre Toxicology 2018 15:21

    Content type: Research

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  12. Pollutant particles containing environmentally persistent free radicals (EPFRs) are formed during many combustion processes (e.g. thermal remediation of hazardous wastes, diesel/gasoline combustion, wood smoke...

    Authors: Sridhar Jaligama, Vivek S. Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R. Mancuso, Tammy R. Dugas and Stephania A. Cormier

    Citation: Particle and Fibre Toxicology 2018 15:20

    Content type: Research

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  13. Diesel exhaust particles (DEP) are a major component of outdoor air pollution. DEP mediated pulmonary effects are plausibly linked to inflammatory and oxidative stress response in which macrophages (MQ), epith...

    Authors: Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde and Lena Palmberg

    Citation: Particle and Fibre Toxicology 2018 15:19

    Content type: Research

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  14. Exposure to ambient fine particulate matter (PM2.5) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial p...

    Authors: Wanjun Wang, Ji Zhou, Minjie Chen, Xingke Huang, Xiaoyun Xie, Weihua Li, Qi Cao, Haidong Kan, Yanyi Xu and Zhekang Ying

    Citation: Particle and Fibre Toxicology 2018 15:17

    Content type: Research

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  15. The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an impor...

    Authors: Yulai Shen, Lu Wu, Dongdong Qin, Yankai Xia, Zhu Zhou, Xuemei Zhang and Xin Wu

    Citation: Particle and Fibre Toxicology 2018 15:16

    Content type: Research

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  16. Titanium dioxide (TiO2) is produced at high volumes and applied in many consumer and food products. Recent toxicokinetic modelling indicated the potential of TiO2 to accumulate in human liver and spleen upon dail...

    Authors: M. B. Heringa, R. J. B. Peters, R. L. A. W. Bleys, M. K. van der Lee, P. C. Tromp, P. C. E. van Kesteren, J. C. H. van Eijkeren, A. K. Undas, A. G. Oomen and H. Bouwmeester

    Citation: Particle and Fibre Toxicology 2018 15:15

    Content type: Research

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  17. Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by...

    Authors: Yang Bai, Hannelore Bové, Tim S. Nawrot and Benoit Nemery

    Citation: Particle and Fibre Toxicology 2018 15:14

    Content type: Research

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  18. Epidemiological studies have suggested that elevated levels of air pollution contribute to an increased incidence or severity of asthma. Although late-onset adult asthma seems to be more attributable to enviro...

    Authors: Mei Mei, Haojun Song, Lina Chen, Bin Hu, Ru Bai, Diandou Xu, Ying Liu, Yuliang Zhao and Chunying Chen

    Citation: Particle and Fibre Toxicology 2018 15:13

    Content type: Research

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  19. Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of particles via food or indirectly by removal of inhaled material from the airways by ...

    Authors: Ditte Marie Jensen, Daniel Vest Christophersen, Majid Sheykhzade, Gry Freja Skovsted, Jens Lykkesfeldt, Rasmus Münter, Martin Roursgaard, Steffen Loft and Peter Møller

    Citation: Particle and Fibre Toxicology 2018 15:12

    Content type: Research

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  20. Inhalation of high concentrations of zinc oxide particles (ZnO) may cause metal fume fever. In an earlier human inhalation study, no effects were observed after exposure to ZnO concentrations of 0.5 mg/m3. Furthe...

    Authors: Christian Monsé, Olaf Hagemeyer, Monika Raulf, Birger Jettkant, Vera van Kampen, Benjamin Kendzia, Vitali Gering, Günther Kappert, Tobias Weiss, Nadin Ulrich, Eike-Maximilian Marek, Jürgen Bünger, Thomas Brüning and Rolf Merget

    Citation: Particle and Fibre Toxicology 2018 15:8

    Content type: Research

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  21. Epidemiological studies link inhalation of particles to increased risk of cardiovascular disease. Inhaled particles may induce cardiovascular disease by several different mechanisms including translocation of ...

    Authors: Ulla Vogel and Flemming R. Cassee

    Citation: Particle and Fibre Toxicology 2018 15:7

    Content type: Editorial

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  22. Subtle DNA methylation alterations mediated by carbon nanotubes (CNTs) exposure might contribute to pathogenesis and disease susceptibility. It is known that both multi-walled carbon nanotubes (MWCNTs) and sin...

    Authors: Deniz Öner, Manosij Ghosh, Hannelore Bové, Matthieu Moisse, Bram Boeckx, Radu C. Duca, Katrien Poels, Katrien Luyts, Eveline Putzeys, Kirsten Van Landuydt, Jeroen AJ Vanoirbeek, Marcel Ameloot, Diether Lambrechts, Lode Godderis and Peter HM Hoet

    Citation: Particle and Fibre Toxicology 2018 15:11

    Content type: Research

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  23. Semen quality parameters are potentially affected by nanomaterials in several ways: Inhaled nanosized particles are potent inducers of pulmonary inflammation, leading to the release of inflammatory mediators. ...

    Authors: Astrid Skovmand, Anna Jacobsen Lauvås, Preben Christensen, Ulla Vogel, Karin Sørig Hougaard and Sandra Goericke-Pesch

    Citation: Particle and Fibre Toxicology 2018 15:10

    Content type: Research

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  24. The use of engineered nanoparticles (NP) is widespread and still increasing. There is a great need to assess their safety. Newly engineered NP enter the market in a large variety; therefore saf...

    Authors: Rob J. Vandebriel, Jolanda P. Vermeulen, Laurens B. van Engelen, Britt de Jong, Lisa M. Verhagen, Liset J. de la Fonteyne-Blankestijn, Marieke E. Hoonakker and Wim H. de Jong

    Citation: Particle and Fibre Toxicology 2018 15:9

    Content type: Research

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  25. The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard r...

    Authors: Dennis G. Thomas, Jordan N. Smith, Brian D. Thrall, Donald R. Baer, Hadley Jolley, Prabhakaran Munusamy, Vamsi Kodali, Philip Demokritou, Joel Cohen and Justin G. Teeguarden

    Citation: Particle and Fibre Toxicology 2018 15:6

    Content type: Research

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  26. Nanoparticles (NPs) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. Here, we describe the modula...

    Authors: Juan Li, Runhong Lei, Xin Li, Fengxia Xiong, Quanyang Zhang, Yue Zhou, Shengmei Yang, Yanan Chang, Kui Chen, Weihong Gu, Chongming Wu and Gengmei Xing

    Citation: Particle and Fibre Toxicology 2018 15:5

    Content type: Research

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  27. Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of air po...

    Authors: Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang and Yuh-Lien Chen

    Citation: Particle and Fibre Toxicology 2018 15:4

    Content type: Research

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  28. The integration of engineered nanomaterials (ENM) is well-established and widespread in clinical, commercial, and domestic applications. Cardiovascular dysfunctions have been reported in adult populations afte...

    Authors: P. A. Stapleton, Q. A. Hathaway, C. E. Nichols, A. B. Abukabda, M. V. Pinti, D. L. Shepherd, C. R. McBride, J. Yi, V. C. Castranova, J. M. Hollander and T. R. Nurkiewicz

    Citation: Particle and Fibre Toxicology 2018 15:3

    Content type: Research

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  29. Little is known about the mechanism underlying the genotoxicity observed in the liver following pulmonary exposure to carbon black (CB) nanoparticles (NPs). The genotoxicity could be caused by the presence of ...

    Authors: Justyna Modrzynska, Trine Berthing, Gitte Ravn-Haren, Nicklas Raun Jacobsen, Ingrid Konow Weydahl, Katrin Loeschner, Alicja Mortensen, Anne Thoustrup Saber and Ulla Vogel

    Citation: Particle and Fibre Toxicology 2018 15:2

    Content type: Research

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  30. Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several...

    Authors: Sarah Robertson and Mark R. Miller

    Citation: Particle and Fibre Toxicology 2018 15:1

    Content type: Review

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  31. Lead is well known environmental pollutant, which can cause toxic effects in multiple organ systems. However, the influence of lead oxide nanoparticles, frequently emitted to the environment by high temperatur...

    Authors: J. Dumková, T. Smutná, L. Vrlíková, P. Le Coustumer, Z. Večeřa, B. Dočekal, P. Mikuška, L. Čapka, P. Fictum, A. Hampl and M. Buchtová

    Citation: Particle and Fibre Toxicology 2017 14:55

    Content type: Research

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  32. Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced l...

    Authors: Xiaobo Li, Hongbao Yang, Shenshen Wu, Qingtao Meng, Hao Sun, Runze Lu, Jian Cui, Yuxin Zheng, Wen Chen, Rong Zhang, Michael Aschner and Rui Chen

    Citation: Particle and Fibre Toxicology 2017 14:53

    Content type: Research

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  33. Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma−/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. ...

    Authors: Sebastian Riedle, Laetitia C. Pele, Don E. Otter, Rachel E. Hewitt, Harjinder Singh, Nicole C. Roy and Jonathan J. Powell

    Citation: Particle and Fibre Toxicology 2017 14:51

    Content type: Research

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  34. To better assess potential hepatotoxicity of nanomaterials, human liver HepG2 cells were exposed for 3 days to five different CeO2 (either 30 or 100 μg/ml), 3 SiO2 based (30 μg/ml) or 1 CuO (3 μg/ml) nanomaterial...

    Authors: Kirk T. Kitchin, Steve Stirdivant, Brian L. Robinette, Benjamin T. Castellon and Xinhua Liang

    Citation: Particle and Fibre Toxicology 2017 14:50

    Content type: Research

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  35. The lung represents the primary entry route for airborne particles into the human body. Most studies addressed possible adverse effects using single (nano)particles, but aerosolic nanoparticles (NPs) tend to a...

    Authors: Estelle Durantie, Dimitri Vanhecke, Laura Rodriguez-Lorenzo, Flavien Delhaes, Sandor Balog, Dedy Septiadi, Joel Bourquin, Alke Petri-Fink and Barbara Rothen-Rutishauser

    Citation: Particle and Fibre Toxicology 2017 14:49

    Content type: Research

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  36. The toxicokinetics of nanomaterials are an important factor in toxicity, which may be affected by slow clearance and/or distribution in the body.

    Authors: Naohide Shinohara, Guihua Zhang, Yutaka Oshima, Toshio Kobayashi, Nobuya Imatanaka, Makoto Nakai, Takeshi Sasaki, Kenji Kawaguchi and Masashi Gamo

    Citation: Particle and Fibre Toxicology 2017 14:48

    Content type: Research

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  37. There is a fundamental gap of knowledge on the health effects caused by the interaction of engineered nanomaterials (ENM) with the gastro-intestinal tract (GIT). This is partly due to the incomplete knowledge ...

    Authors: Antonio Pietroiusti, Enrico Bergamaschi, Marcello Campagna, Luisa Campagnolo, Giuseppe De Palma, Sergio Iavicoli, Veruscka Leso, Andrea Magrini, Michele Miragoli, Paola Pedata, Leonardo Palombi and Ivo Iavicoli

    Citation: Particle and Fibre Toxicology 2017 14:47

    Content type: Review

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  38. Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse...

    Authors: Cécile Vignal, Muriel Pichavant, Laurent Y. Alleman, Madjid Djouina, Florian Dingreville, Esperanza Perdrix, Christophe Waxin, Adil Ouali Alami, Corinne Gower-Rousseau, Pierre Desreumaux and Mathilde Body-Malapel

    Citation: Particle and Fibre Toxicology 2017 14:46

    Content type: Research

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  39. Asthma is a chronic respiratory disease known for its high susceptibility to environmental exposure. Inadvertent inhalation of engineered or incidental nanomaterials is a concern for human health, particularly...

    Authors: Kirsty Meldrum, Chang Guo, Emma L. Marczylo, Timothy W. Gant, Rachel Smith and Martin O. Leonard

    Citation: Particle and Fibre Toxicology 2017 14:45

    Content type: Review

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  40. Multi-walled carbon nanotubes (MWCNTs) are engineered nanomaterials used for a variety of industrial and consumer products. Their high tensile strength, hydrophobicity, and semi-conductive properties have enab...

    Authors: Ryan J. Snyder, Salik Hussain, Charles J. Tucker, Scott H. Randell and Stavros Garantziotis

    Citation: Particle and Fibre Toxicology 2017 14:44

    Content type: Research

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  41. Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure le...

    Authors: Alicia Sanchez, Julio L. Alvarez, Kateryna Demydenko, Carole Jung, Yeranddy A. Alpizar, Julio Alvarez-Collazo, Stevan M. Cokic, Miguel A. Valverde, Peter H. Hoet and Karel Talavera

    Citation: Particle and Fibre Toxicology 2017 14:43

    Content type: Research

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  42. We previously showed that cerium oxide (CeO2), barium sulfate (BaSO4) and zinc oxide (ZnO) nanoparticles (NPs) exhibited different lung toxicity and pulmonary clearance in rats. We hypothesize that these NPs acqu...

    Authors: Nagarjun V. Konduru, Ramon M. Molina, Archana Swami, Flavia Damiani, Georgios Pyrgiotakis, Paulo Lin, Patrizia Andreozzi, Thomas C. Donaghey, Philip Demokritou, Silke Krol, Wolfgang Kreyling and Joseph D. Brain

    Citation: Particle and Fibre Toxicology 2017 14:42

    Content type: Research

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  43. The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect cell...

    Authors: Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo del Pino, Sebastián Menao, Marcelo de las Heras, Maykel Arias, Scott G. Mitchell, Beatriz Pelaz, Eva M. Gálvez, Jesús M. de la Fuente and Julián Pardo

    Citation: Particle and Fibre Toxicology 2017 14:41

    Content type: Research

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  44. Engineered nanomaterials (ENMs) are increasingly added to foods to improve their quality, sensory appeal, safety and shelf-life. Human exposure to these ingested ENMs (iENMS) is inevitable, yet little is known...

    Authors: Glen M. DeLoid, Yanli Wang, Klara Kapronezai, Laura Rubio Lorente, Roujie Zhang, Georgios Pyrgiotakis, Nagarjun V. Konduru, Maria Ericsson, Jason C. White, Roberto De La Torre-Roche, Hang Xiao, David Julian McClements and Philip Demokritou

    Citation: Particle and Fibre Toxicology 2017 14:40

    Content type: Methodology

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  45. Toxicity of airborne particulate matter (PM) is difficult to assess because PM composition is complex and variable due to source contribution and atmospheric transformation. In this study, we used an in vitro ...

    Authors: Ngoc Q. Vuong, Dalibor Breznan, Patrick Goegan, Julie S. O’Brien, Andrew Williams, Subramanian Karthikeyan, Premkumari Kumarathasan and Renaud Vincent

    Citation: Particle and Fibre Toxicology 2017 14:39

    Content type: Research

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  46. We and other groups have demonstrated that exposure to cobalt nanoparticles (Nano-Co) caused oxidative stress and inflammation, which have been shown to be strongly associated with genotoxic and carcinogenic e...

    Authors: Rong Wan, Yiqun Mo, Zhenyu Zhang, Mizu Jiang, Shichuan Tang and Qunwei Zhang

    Citation: Particle and Fibre Toxicology 2017 14:38

    Content type: Research

    Published on:

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